Search Results - "Hutmacher, DW"

CD73 and CD29 concurrently mediate the mechanically induced decrease of migratory capacity of mesenchymal stromal cells by Ode, A, Kopf, J, Kurtz, A, Schmidt-Bleek, K, Schrade, P, Kolar, P, Buttgereit, F, Lehmann, K, Hutmacher, D W, Duda, G N, Kasper, G

“…e assumption that mesenchymal stromal cell (MSC)-based-therapies are capable of augmenting physiological regeneration processes has fostered intensive basic…”
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A comparison of micro CT with other techniques used in the characterization of scaffolds by Ho, Saey Tuan, Hutmacher, Dietmar W.

“…The structure and architecture of scaffolds are crucial factors in scaffold-based tissue engineering as they affect the functionality of the tissue engineered…”
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Scaffolds in tissue engineering bone and cartilage by Hutmacher, Dietmar W.

“…Musculoskeletal tissue, bone and cartilage are under extensive investigation in tissue engineering research. A number of biodegradable and bioresorbable…”
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Concepts of scaffold‐based tissue engineering—the rationale to use solid free‐form fabrication techniques by Hutmacher, D.W., Cool, S.

“…•  Introduction •  Scaffolds for bone engineering fabricated by solid free‐form fabrication •  Scaffolds combined with growth factors and other biologically…”
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An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues by Bas, Onur, D’Angella, Davide, Baldwin, Jeremy G, Castro, Nathan J, Wunner, Felix M, Saidy, Navid T, Kollmannsberger, Stefan, Reali, Alessandro, Rank, Ernst, De-Juan-Pardo, Elena M, Hutmacher, Dietmar W

“…We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The…”
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Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems by Hutmacher, Dietmar W, Sittinger, Michael, Risbud, Makarand V

“…One of the milestones in tissue engineering has been the development of 3D scaffolds that guide cells to form functional tissue. Recently, mouldless…”
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Scaffold design and fabrication technologies for engineering tissues - state of the art and future perspectives by Hutmacher, Dietmar W.

“…Today, tissue engineers are attempting to engineer virtually every human tissue. Potential tissue-engineered products include cartilage, bone, heart valves,…”
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3‐Dimensional functionalized polycaprolactone‐hyaluronic acid hydrogel constructs for bone tissue engineering by Hamlet, Stephen M., Vaquette, Cedryck, Shah, Amit, Hutmacher, Dietmar W., Ivanovski, Saso

“…Aim Alveolar bone regeneration remains a significant clinical challenge in periodontology and dental implantology. This study assessed the mineralized tissue…”
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Fused deposition modeling of novel scaffold architectures for tissue engineering applications by Zein, Iwan, Hutmacher, Dietmar W., Tan, Kim Cheng, Teoh, Swee Hin

“…Fused deposition modeling, a rapid prototyping technology, was used to produce novel scaffolds with honeycomb-like pattern, fully interconnected channel…”
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Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone by Dondossola, Eleonora, Alexander, Stephanie, Holzapfel, Boris M, Filippini, Stefano, Starbuck, Michael W, Hoffman, Robert M, Navone, Nora, De-Juan-Pardo, Elena M, Logothetis, Christopher J, Hutmacher, Dietmar W, Friedl, Peter

“…Intravital multiphoton microscopy (iMPM) in mice provides access to cellular and molecular mechanisms of metastatic progression of cancers and the underlying…”
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Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study by Shafiee, Abbas, McGovern, Jacqui A., Lahr, Christoph A., Meinert, Christoph, Moi, Davide, Wagner, Ferdinand, Landgraf, Marietta, De‐Juan‐Pardo, Elena, Mazzieri, Roberta, Hutmacher, Dietmar W.

“…Despite significant advances, most current in vivo models fail to fully recapitulate the biological processes that occur in humans. Here we aimed to develop an…”
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Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma by Wagner, Ferdinand, Holzapfel, Boris M., McGovern, Jacqui A., Shafiee, Abbas, Baldwin, Jeremy G., Martine, Laure C., Lahr, Christoph A., Wunner, Felix M., Friis, Thor, Bas, Onur, Boxberg, Melanie, Prodinger, Peter M., Shokoohmand, Ali, Moi, Davide, Mazzieri, Roberta, Loessner, Daniela, Hutmacher, Dietmar W.

“…Existing preclinical murine models often fail to predict effects of anti-cancer drugs. In order to minimize interspecies-differences between murine hosts and…”
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Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits by Shao, Xin Xin, Hutmacher, Dietmar W., Ho, Saey Tuan, Goh, James C.H., Lee, Eng Hin

“…The objective of this study was to evaluate the feasibility and potential of a hybrid scaffold system in large- and high-load-bearing osteochondral defects…”
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Current strategies for cell delivery in cartilage and bone regeneration by Sittinger, Michael, Hutmacher, Dietmar W, Risbud, Makarand V

“…Several cell-based tissue-engineering therapies are emerging to regenerate damaged tissues. These strategies use autologous cells in combination with…”
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Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2 by Rai, B., Teoh, S.H., Hutmacher, D.W., Cao, T., Ho, K.H.

“…This study investigated a novel drug delivery system (DDS), consisting of polycaprolactone (PCL) or polycaprolactone 20% tricalcium phosphate (PCL-TCP)…”
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A humanised tissue‐engineered bone model allows species‐specific breast cancer‐related bone metastasis in vivo by Quent, VMC, Taubenberger, AV, Reichert, JC, Martine, LC, Clements, JA, Hutmacher, DW, Loessner, D

“…Bone metastases frequently occur in the advanced stages of breast cancer. At this stage, the disease is deemed incurable. To date, the mechanisms of breast…”
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In vitro characterization of natural and synthetic dermal matrices cultured with human dermal fibroblasts by Ng, K.W., Khor, H.L., Hutmacher, D.W.

“…The ideal dermal matrix should be able to provide the right biological and physical environment to ensure homogenous cell and extracellular matrix (ECM)…”
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Application of micro CT and computation modeling in bone tissue engineering by Tuan, Ho Saey, Hutmacher, Dietmar W.

“…Computer aided technologies, medical imaging, and rapid prototyping has created new possibilities in biomedical engineering. The systematic variation of…”
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Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging by Jones, Anthony C., Milthorpe, Bruce, Averdunk, Holger, Limaye, Ajay, Senden, Tim J., Sakellariou, Arthur, Sheppard, Adrian P., Sok, Rob M., Knackstedt, Mark A., Brandwood, Arthur, Rohner, Dennis, Hutmacher, Dietmar W.

“…This paper illustrates the utility of micro-computed tomography (micro-CT) to study the process of tissue engineered bone growth. A micro-CT facility for…”
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The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds by Rai, B, Teoh, S.H, Ho, K.H, Hutmacher, D.W, Cao, T, Chen, F, Yacob, K

“…Our strategy entails investigating the influence of varied concentrations (0, 10, 100 and 1000 ng/ml) of human recombinant bone morphogenetic protein-2…”
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