Search Results - "Huth, J. R."

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties by Liu, Gang, Huth, Jeffrey R, Olejniczak, Edward T, Mendoza, Renaldo, DeVries, Peter, Leitza, Sandra, Reilly, Edward B, Okasinski, Gregory F, Fesik, Stephen W, von Geldern, Thomas W

“…The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and…”
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Comparative Performance of Corymbia Hybrids and Parental Species in Subtropical Queensland and Implications for Breeding and Deployment by Lee, David J., Huth, J. R., Brawner, J. T., Dickinson, G. R.

“…Eighty six full-sib Corymbia F1 hybrid families (crosses between C. torelliana and four spotted gum taxa: C. citriodora subsp. variegata, C. citriodora subsp…”
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Intracellular folding pathway of human chorionic gonadotropin beta subunit by HUTH, J. R, MOUNTJOY, K, PERINI, F, RUDDON, R. W

“…Few experimental models have been used to investigate how proteins fold inside a cell. Using the formation of disulfide bonds as an index of conformational…”
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Disulfide bond mutations affect the folding of the human chorionic gonadotropin-beta subunit in transfected Chinese hamster ovary cells by BEDOWS, E, HUTH, J. R, SUGANUMA, N, BARTELS, C. F, BOIME, I, RUDDON, R. W

“…Previous kinetic studies have characterized the intracellular folding pathway of the human chorionic gonadotropin (hCG)-beta subunit in which each of the…”
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Coating nursery containers with copper carbonate improves root morphology of five native Australian tree species used in agroforestry systems by DUNN, G. M, HUTH, J. R, LEWTY, M. J

“…Seedlings of the native Australian tree species Acacia holosericea, Casuarina cunninghamiana, Eucalyptus argophloia, E. camaldulensis and Melaleuca bracteata,…”
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Domain-dependent protein folding is indicated by the intracellular kinetics of disulfide bond formation of human chorionic gonadotropin beta subunit by Huth, J.R., Mountjoy, K, Perini, F, Bedows, E, Ruddon, R.W.

“…We have measured the intracellular rates of formation of the six disulfide bonds in the human chorionic gonadotropin beta subunit (hCG-beta) to determine…”
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Misfolded human chorionic gonadotropin beta subunits are secreted from transfected Chinese hamster ovary cells by BEDOWS, E, NORTON, S. E, HUTH, J. R, SUGANUMA, N, BOIME, I, RUDDON, R. W

“…There are six intramolecular disulfide (S-S) bonds that form during intracellular folding of the human chorionic gonadotropin (hCG)-beta subunit. Site-directed…”
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Kinetics of folding and assembly of the human chorionic gonadotropin beta subunit in transfected Chinese hamster ovary cells by BEDOWS, E, HUTH, J. R, RUDDON, R. W

“…We have employed Chinese hamster ovary (CHO) cell lines transfected with either the wild type human chorionic gonadotropin beta (hCG-beta) gene alone (CHO beta…”
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Design of an expression system for detecting folded protein domains and mapping macromolecular interactions by NMR by Huth, Jeffrey R., Bewley, Carole A., Clore, G. Marius, Gronenborn, Angela M., Jackson, Belinda M., Hinnebusch, Alan G.

“…Two protein expression vectors have been designed for the preparation of NMR samples. The vectors encode the immunoglobulin‐binding domain of streptococcal…”
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Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 4. Structure−Activity Relationship of Substituents on the Benzene Ring of the Cinnamide by Winn, Martin, Reilly, Edward B, Liu, Gang, Huth, Jeffrey R, Jae, Hwan-Soo, Freeman, Jennifer, Pei, Zhonghua, Xin, Zhili, Lynch, John, Kester, Jeff, von Geldern, Thomas W, Leitza, Sandra, DeVries, Peter, Dickinson, Robert, Mussatto, Donna, Okasinski, Gregory F

“…We have shown that p-arylthio cinnamides can inhibit the interaction of LFA-1 and ICAM-1, which is involved in cell adhesion and the inflammatory process. We…”
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Discovery of Potent Antagonists of Leukocyte Function-Associated Antigen-1/Intercellular Adhesion Molecule-1 Interaction. 3. Amide (C-Ring) Structure−Activity Relationship and Improvement of Overall Properties of Arylthio Cinnamides by Pei, Zhonghua, Xin, Zhili, Liu, Gang, Li, Yihong, Reilly, Edward B, Lubbers, Nathan L, Huth, Jeffery R, Link, James T, von Geldern, Thomas W, Cox, Bryan F, Leitza, Sandra, Gao, Yi, Marsh, Kennan C, DeVries, Peter, Okasinski, Greg F

“…The interaction of LFA-1 and ICAM-1 plays an important role in the cell adhesion process. On the basis of previously reported SAR and structural information on…”
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Small-tree volume equations for subtropical hardwood plantation species by Hogg, B. W., Lewis, T., Huth, J. R., Lee, D. J.

“…Estimation of stem volume is needed to determine timber yield and forest carbon, but equations to estimate volume from easily assessed inventory measures are…”
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Predicting protein druggability by Hajduk, Philip J., Huth, Jeffrey R., Tse, Christin

“…New experimental and computational approaches promise to rapidly and reliably identify druggable, disease-modifying targets and thereby streamline the drug…”
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Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase by Huth, J R, Perini, F, Lockridge, O, Bedows, E, Ruddon, R W

“…Although purified proteins will refold and assemble in vitro, it is not known if cellular factors change the mechanisms of these processes. Based on the gel…”
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Domestication of northern sandalwood (Santalum lanceolatum, Santalaceae) for Indigenous forestry on the Cape York Peninsula by Lee, D. J., Burridge, A. J., Page, T., Huth, J. R., Thompson, N.

“…Over recent decades there has been considerable private investment in developing a sandalwood (Santalum spp.) industry due to the high international demand for…”
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Druggability Indices for Protein Targets Derived from NMR-Based Screening Data by Hajduk, Philip J, Huth, Jeffrey R, Fesik, Stephen W

“…An analysis of heteronuclear-NMR-based screening data is used to derive relationships between the ability of small molecules to bind to a protein and various…”
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The Wing of the Enhancer-Binding Domain of Mu Phage Transposase is Flexible and is Essential for Efficient Transposition by Clubb, Robert T., Mizuuchi, Michiyo, Huth, Jeffrey R., Omichinski, James G., Savilahti, Harri, Mizuuchi, Kiyoshi, Clore, G. Marius, Gronenborn, Angela M.

“…A tetramer of the Mu transposase (MuA) pairs the recombination sites, cleaves the donor DNA, and joins these ends to a target DNA by strand transfer…”
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Selecting hardwood taxa for wood and fibre production in Queensland’s subtropics by Lee, D.J, Huth, J.R, Osborne, D.O, Hogg, B.W

“…Optimal matching of species to sites is required for a sustainable hardwood plantation industry in the subtropics. This paper reports the performance and…”
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Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex by Werner, Milton H, Huth, Jeffrey R, Gronenborn, Angela M, Marius Clore, G

“…The solution structure of the specific complex between the high mobility group (HMG) domain of SRY (hSRY-HMG), the protein encoded by the human…”
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Combination of the chorionic gonadotropin free beta-subunit with alpha by Beebe, J S, Huth, J R, Ruddon, R W

“…The rate-limiting event for combination of hCG alpha- and beta-subunits in JAR choriocarcinoma cells is the rate of disulfide bond formation in the…”
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