Search Results - "Hutchinson, Edward C."

Conserved and host-specific features of influenza virion architecture by Hutchinson, Edward C., Charles, Philip D., Hester, Svenja S., Thomas, Benjamin, Trudgian, David, Martínez-Alonso, Mónica, Fodor, Ervin

“…Viruses use virions to spread between hosts, and virion composition is therefore the primary determinant of viral transmissibility and immunogenicity. However,…”
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Interactome analysis of the influenza A virus transcription/replication machinery identifies protein phosphatase 6 as a cellular factor required for efficient virus replication by York, Ashley, Hutchinson, Edward C, Fodor, Ervin

“…The negative-sense RNA genome of influenza A virus is transcribed and replicated by the viral RNA-dependent RNA polymerase (RdRP). The viral RdRP is an…”
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Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry by Hutchinson, Edward C, Denham, Eleanor M, Thomas, Benjamin, Trudgian, David C, Hester, Svenja S, Ridlova, Gabriela, York, Ashley, Turrell, Lauren, Fodor, Ervin

“…Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass…”
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Influenza Virus by Hutchinson, Edward C.

“…[Display omitted] This infographic briefly summarises the natural history, replication cycle, and pathogenesis of influenza viruses, the cause of seasonal…”
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Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection by Gestuveo, Rommel J., Royle, Jamie, Donald, Claire L., Lamont, Douglas J., Hutchinson, Edward C., Merits, Andres, Kohl, Alain, Varjak, Margus

“…The escalating global prevalence of arboviral diseases emphasizes the need to improve our understanding of their biology. Research in this area has been…”
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Regulation of influenza A virus nucleoprotein oligomerization by phosphorylation by Turrell, Lauren, Hutchinson, Edward C, Vreede, Frank T, Fodor, Ervin

“…In the influenza virus ribonucleoprotein complex, the oligomerization of the nucleoprotein is mediated by an interaction between the tail-loop of one molecule…”
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Identification of a novel splice variant form of the influenza A virus M2 ion channel with an antigenically distinct ectodomain by Wise, Helen M, Hutchinson, Edward C, Jagger, Brett W, Stuart, Amanda D, Kang, Zi H, Robb, Nicole, Schwartzman, Louis M, Kash, John C, Fodor, Ervin, Firth, Andrew E, Gog, Julia R, Taubenberger, Jeffery K, Digard, Paul

“…Segment 7 of influenza A virus produces up to four mRNAs. Unspliced transcripts encode M1, spliced mRNA2 encodes the M2 ion channel, while protein products…”
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Transport of the influenza virus genome from nucleus to nucleus by Hutchinson, Edward C, Fodor, Ervin

“…The segmented genome of an influenza virus is encapsidated into ribonucleoprotein complexes (RNPs). Unusually among RNA viruses, influenza viruses replicate in…”
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Mutational Analysis of cis-Acting RNA Signals in Segment 7 of Influenza A Virus by HUTCHINSON, Edward C, CURRAN, Martin D, READ, Eliot K, GOG, Julia R, DIGARD, Paul

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5 by HUTCHINSON, Edward C, ORR, Olivia E, MAN LIU, Sai, ENGELHARDT, Othmar G, FODOR, Ervin

“…The influenza A virus RNA polymerase is a heterotrimer that transcribes and replicates the viral genome in the cell nucleus. Newly synthesized RNA polymerase…”
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Filamentous influenza viruses by Dadonaite, Bernadeta, Vijayakrishnan, Swetha, Fodor, Ervin, Bhella, David, Hutchinson, Edward C

“…Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that…”
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Understanding Influenza by Hutchinson, Edward C, Yamauchi, Yohei

“…Influenza, a serious illness of humans and domesticated animals, has been studied intensively for many years. It therefore provides an example of how much we…”
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Studies of an Influenza A Virus Temperature-Sensitive Mutant Identify a Late Role for NP in the Formation of Infectious Virions by NOTON, Sarah L, SIMPSON-HOLLEY, Martha, MEDCALF, Elizabeth, WISE, Helen M, HUTCHINSON, Edward C, MCCAULEY, John W, DIGARD, Paul

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Purification and Proteomics of Influenza Virions by Hutchinson, Edward C, Stegmann, Monika

“…This chapter describes a basic workflow for analyzing the protein composition of influenza virions. In order to obtain suitable material, the chapter describes…”
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Corrigendum: Single-particle measurements of filamentous influenza virions reveal damage induced by freezing by Hirst, Jack C, Hutchinson, Edward C

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Single-particle measurements of filamentous influenza virions reveal damage induced by freezing by Hirst, Jack C, Hutchinson, Edward C

“…Clinical isolates of influenza virus produce pleiomorphic virions, ranging from small spheres to elongated filaments. The filaments are seemingly adaptive in…”
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Genome packaging in influenza A virus by Hutchinson, Edward C, von Kirchbach, Johann C, Gog, Julia R, Digard, Paul

“…1 Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK 2 DAMTP, Centre for Mathematical Sciences,…”
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Characterisation of influenza A viruses with mutations in segment 5 packaging signals by Hutchinson, Edward C, Wise, Helen M, Kudryavtseva, Katerine, Curran, Martin D, Digard, Paul

“…Abstract Influenza A virus vRNA segments contain specific packaging signals at their termini that overlap the coding regions. To further characterise segment 5…”
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Erratum: Conserved and host-specific features of influenza virion architecture by Hutchinson, Edward C., Charles, Philip D., Hester, Svenja S., Thomas, Benjamin, Trudgian, David, Martínez-Alonso, Mónica, Fodor, Ervin

“…Nature Communications 4: Article number: 4816 (2014); Published 16 September 2014; Updated 17 February 2015. In the last paragraph of the Methods section in…”
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MAIT cells are activated during human viral infections by van Wilgenburg, Bonnie, Scherwitzl, Iris, Hutchinson, Edward C., Leng, Tianqi, Kurioka, Ayako, Kulicke, Corinna, de Lara, Catherine, Cole, Suzanne, Vasanawathana, Sirijitt, Limpitikul, Wannee, Malasit, Prida, Young, Duncan, Denney, Laura, Moore, Michael D., Fabris, Paolo, Giordani, Maria Teresa, Oo, Ye Htun, Laidlaw, Stephen M., Dustin, Lynn B., Ho, Ling-Pei, Thompson, Fiona M., Ramamurthy, Narayan, Mongkolsapaya, Juthathip, Willberg, Christian B., Screaton, Gavin R., Klenerman, Paul

“…Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated…”
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