Search Results - "Hutchins, JT"

Abstract P2-04-12: Targeting of phosphatidylserine by monoclonal antibodies enhances the activity of immune checkpoint lag3 targeting antibodies in murine breast tumors by Gray, MJ, Gong, J, Hutchins, JT, Freimark, BD

“…Abstract Previous preclinical modeling has demonstrated that antibodies targeting the programmed cell death ligand 1 (PD-1) have activity in murine breast…”
Get full text

Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580 by James G. Conway, McDonald, Brad, Janet Parham, Barry Keith, David W. Rusnak, Eva Shaw, Jansen, Marilyn, Peiyuan Lin, Alan Payne, Renae M. Crosby, Jennifer H. Johnson, Lloyd Frick, Min-Hwa Jasmine Lin, Scott Depee, Sarva Tadepalli, Bart Votta, James, Ian, Karen Fuller, Timothy J. Chambers, Kull, Frederick C., Stanley D. Chamberlain, Hutchins, Jeff T., Schlessinger, Joseph

“…Colony-stimulating-factoM (CSF-1) signaling through cFMS receptor kinase is increased in several diseases. To help investigate the role of cFMS kinase in…”
Get full text

Characterization of a Protective Monoclonal Antibody Recognizing Staphylococcus aureus MSCRAMM Protein Clumping Factor A by HALL, Andrea E, DOMANSKI, Paul J, PATEL, Pratiksha R, VERNACHIO, John H, SYRIBEYS, Peter J, GOROVITS, Elena L, JOHNSON, Michael A, ROSS, Julia M, HUTCHINS, Jeff T, PATTI, Joseph M

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Characterization of a Humanized Monoclonal Antibody Recognizing Clumping Factor A Expressed by Staphylococcus aureus by Domanski, Paul J, Patel, Pratiksha R, Bayer, Arnold S, Zhang, Li, Hall, Andrea E, Syribeys, Peter J, Gorovits, Elena L, Bryant, Dawn, Vernachio, John H, Hutchins, Jeff T, Patti, Joseph M

“…We report the humanization and characterization of monoclonal antibody (MAb) T1-2 or tefibazumab, a monoclonal antibody that recognizes clumping factor A…”
Get full text

Site-specific Conjugation on Serine → Cysteine Variant Monoclonal Antibodies by Stimmel, Julie B., Merrill, Barbara M., Kuyper, Lee F., Moxham, Cary P., Hutchins, Jeff T., Fling, Mary E., Kull, Frederick C.

“…We have engineered a cysteine residue at position 442 (EU/OU numbering) in the third constant domain (CH3) of the heavy chain of several IgGs with different…”
Get full text

Immunogenicity of Thrombopoietin Mimetic Peptide GW395058 in BALB/c Mice and New Zealand White Rabbits: Evaluation of the Potential for Thrombopoietin Neutralizing Antibody Production in Man by De Serres, Mark, Ellis, Byron, Dillberger, John E., Rudolph, Sharon K., Hutchins, Jeff T., Boytos, Christine M., Weigl, Debra L., DePrince, Randolph B.

“…Administration of exogenous proteins and peptides as therapeutics carries with it the potential for immune system recognition and the development of…”
Get full text

Production of monoclonal antibodies using recombinant baculovirus displaying gp64–fusion proteins by Lindley, Kathryn M, Su, Jui-Lan, Hodges, Paula K, Wisely, G.Bruce, Bledsoe, Randy K, Condreay, J.Patrick, Winegar, Deborah A, Hutchins, Jeff T, Kost, Thomas A

“…Generation of protein immunogens is often a rate-limiting step in the production of monoclonal antibodies (Mabs). Expressing domains of proteins as fusions to…”
Get full text

Effects of pCIneo and pCEP4 expression vectors on transient and stable protein production in human and simian cell lines by PARHAM, Janet H, KOST, Tom, HUTCHINS, Jeff T

“…To support and meet the demand for recombinant proteins early in the drug discovery process, much work has been directed toward improving the methods used for…”
Get full text

Shorter development of immunoassay for drugs: application of the novel RIMMS technique enables rapid production of monoclonal antibodies to ranitidine by Wring, Stephen A., Kilpatrick, Katherine E., Hutchins, Jeff T., Witherspoon, Samual M., Ellis, Byron, Jenner, William N., Serabjit-Singh, Cosette

“…High affinity, specific murine monoclonal antibodies have been produced for ranitidine using the novel RIMMS (repetitive immunizations, multiple sites)…”
Get full text

Improved biodistribution, tumor targeting, and reduced immunogenicity in mice with a gamma 4 variant of Campath-1H by J T Hutchins, F C Kull, Jr, J Bynum, V C Knick, L M Thurmond, P Ray

“…Radiolabeled antibodies have shown promise for the treatment of lymphoma and for solid tumor targeting. Campath-1H is a humanized monoclonal antibody that…”
Get full text

The chicken junD gene and its product by Hartl, M, Hutchins, J T, Vogt, P K

“…We have isolated and characterized the chicken junD gene. It does not contain an intron; its upstream regulatory sequences lack the AP-1-binding site seen in…”
Get more information

Optimization of transient gene expression in mammalian cells and potential for scale-up using flow electroporation by Parham, J H, Iannone, M A, Overton, L K, Hutchins, J T

“…The goals of this study were to identify mammalian cell lines which could be efficiently transiently-transfected and scaled-up for protein production. The…”
Get full text

Novel gene sequences expressed by human melanoma cells identified by molecular subtraction by HUTCHINS, J. T, DEANS, R. J, MITCHELL, M. S, UCHIYAMA, C, KAN-MITCHELL, J

“…Despite the variety of approaches used, only a limited number of tumor-associated antigens have been described for each histological type of tumor. In this…”
Get full text

Carbohydrate structure in tumor immunity by Reading, C L, Hutchins, J T

“…Researchers have endeavored to define surface alterations associated with neoplasia for at least 25 years. In comparisons of normal tissues with animal and…”
Get full text

Generation of murine monoclonal antihuman milk fat globule membrane antibodies using immunoprecipitation and BIAcore analyses by Bynum, J, Hutchins, J T, Kull, Jr, F C

“…A selection of monoclonal antibodies was developed against deoxycholine-solubilized human milk fat globule membranes (HMFG). The antibodies were selected for…”
Get more information

In vivo expression of a GST-fusion protein mediates the rapid generation of affinity matured monoclonal antibodies using DNA-based immunizations by Kilpatrick, Katherine E, Kerner, Sandy, Dixon, Eric P, Hutchins, Jeff T, Parham, Janet H, Condreay, J Patrick, Pahel, Gregory

“…Previously we demonstrated the rapid generation of affinity matured monoclonal antibody (MAb) producing cell lines following gene gun delivery of DNA using a…”
Get more information

Flow cytometric analysis of the effect of ara-C on the chronobiology of bone marrow DNA synthesis by Hromas, R A, Hutchins, J T, Markel, D E, Scholes, V E

“…Flow cytometry, a technique which allows rapid quantitation of the percentages of a cell population in the various cell cycle phases, closely duplicated the…”
Get more information