Search Results - "Hutchins, Gary D"

Characterization of 11C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation by Territo, Paul R, Meyer, Jill A, Peters, Jonathan S, Riley, Amanda A, McCarthy, Brian P, Gao, Mingzhang, Wang, Min, Green, Mark A, Zheng, Qi-Huang, Hutchins, Gary D

“…The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has…”
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Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial by Robertson, Kent A, Dr, Nalepa, Grzegorz, MD, Yang, Feng-Chun, MD, Bowers, Daniel C, MD, Ho, Chang Y, MD, Hutchins, Gary D, Prof, Croop, James M, Prof, Vik, Terry A, MD, Denne, Scott C, Prof, Parada, Luis F, Prof, Hingtgen, Cynthia M, MD, Walsh, Laurence E, MD, Yu, Menggang, PhD, Pradhan, Kamnesh R, MD, Edwards-Brown, Mary K, Prof, Cohen, Mervyn D, Prof, Fletcher, James W, Prof, Travers, Jeffrey B, Prof, Staser, Karl W, PhD, Lee, Melissa W, BS, Sherman, Marcie R, BS, Davis, Cynthia J, RN, Miller, Lucy C, RN, Ingram, David A, Prof, Clapp, D Wade, Prof

“…Summary Background Plexiform neurofibromas are slow-growing chemoradiotherapy-resistant tumours arising in patients with neurofibromatosis type 1 (NF1)…”
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Pancreatic Cancer: Utility of Dynamic Contrast-enhanced MR Imaging in Assessment of Antiangiogenic Therapy by FATIH AKISIK, M, SANDRASEGARAN, Kumaresan, GUIXUE BU, CHEN, HUTCHINS, Gary D, CHIOREAN, Elena G

“…To prospectively evaluate the utility of dynamic contrast material-enhanced magnetic resonance (MR) imaging in predicting the response of locally advanced…”
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Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor by Wang, Min, Gao, Mingzhang, Meyer, Jill A., Peters, Jonathan S., Zarrinmayeh, Hamideh, Territo, Paul R., Hutchins, Gary D., Zheng, Qi-Huang

“…[Display omitted] P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases…”
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Comparison of tracer kinetic models for 68Ga-PSMA-11 PET in intermediate-risk primary prostate cancer patients by Smith, Nathaniel J., Green, Mark A., Bahler, Clinton D., Tann, Mark, Territo, Wendy, Smith, Anne M., Hutchins, Gary D.

“…Background 68 Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical…”
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Autologous bone marrow mononuclear cell therapy is safe and promotes amputation-free survival in patients with critical limb ischemia by Murphy, Michael P., MD, Lawson, Jeffrey H., MD, PhD, Rapp, Brian M., MD, Dalsing, Michael C., MD, Klein, Janet, RN, Wilson, Michael G., PhD, Hutchins, Gary D., PhD, March, Keith L., MD, PhD

“…Objective The purpose of this Phase I open label nonrandomized trial was to assess the safety and efficacy of autologous bone marrow mononuclear cell (ABMNC)…”
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Use of multimodality imaging, histology, and treatment feasibility to characterize a transgenic Rag2 -null rat model of glioblastoma by Jackson, Luke R, Masi, Megan R, Selman, Bryce M, Sandusky, George E, Zarrinmayeh, Hamideh, Das, Sudip K, Maharjan, Surendra, Wang, Nian, Zheng, Qi-Huang, Pollok, Karen E, Snyder, Scott E, Sun, Phillip Zhe, Hutchins, Gary D, Butch, Elizabeth R, Veronesi, Michael C

“…Many drugs that show potential in animal models of glioblastoma (GBM) fail to translate to the clinic, contributing to a paucity of new therapeutic options. In…”
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Novel application of complementary imaging techniques to examine in vivo glucose metabolism in the kidney by Hato, Takashi, Friedman, Allon N, Mang, Henry, Plotkin, Zoya, Dube, Shataakshi, Hutchins, Gary D, Territo, Paul R, McCarthy, Brian P, Riley, Amanda A, Pichumani, Kumar, Malloy, Craig R, Harris, Robert A, Dagher, Pierre C, Sutton, Timothy A

“…The metabolic status of the kidney is a determinant of injury susceptibility and a measure of progression for many disease processes; however, noninvasive…”
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Microsphere Localization and Dose Quantification Using Positron Emission Tomography/CT following Hepatic Intraarterial Radioembolization with Yttrium-90 in Patients with Advanced Hepatocellular Carcinoma by Lea, William B., MD, Tapp, Katie N., BS, Tann, Mark, MD, Hutchins, Gary D., PhD, Fletcher, James W., MD, Johnson, Matthew S., MD

“…Abstract Purpose To characterize the distribution of absorbed radiation dose after glass microsphere radioembolization for hepatocellular carcinoma (HCC) using…”
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Effects of combination treatment with alendronate and raloxifene on skeletal properties in a beagle dog model by Allen, Matthew R, McNerny, Erin, Aref, Mohammad, Organ, Jason M, Newman, Christopher L, McGowan, Brian, Jang, Tim, Burr, David B, Brown, Drew M, Hammond, Max, Territo, Paul R, Lin, Chen, Persohn, Scott, Jiang, Lei, Riley, Amanda A, McCarthy, Brian P, Hutchins, Gary D, Wallace, Joseph M

“…A growing number of studies have investigated combination treatment as an approach to treat bone disease. The goal of this study was to investigate the…”
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Positron Emission Tomography (PET) Assessment of Renal Perfusion by Green, Mark A., PhD, Hutchins, Gary D., PhD

“…Summary Positron emission tomography (PET) is a radionuclide imaging technique that allows noninvasive mapping of radiopharmaceutical concentrations in…”
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Fully automated synthesis and initial PET evaluation of [ 11C]PBR28 by Wang, Min, Yoder, Karmen K., Gao, Mingzhang, Mock, Bruce H., Xu, Xiao-Ming, Saykin, Andrew J., Hutchins, Gary D., Zheng, Qi-Huang

“…Fully automated synthesis and initial PET evaluation of a TSPO radioligand [ 11C]PBR28 are reported. Fully automated synthesis and initial PET evaluation of a…”
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A Comparison of Arterial Input Function Interpolation Methods for Patlak Plot Analysis of 68 Ga-PSMA-11 PET Prostate Cancer Studies by Smith, Nathaniel J, Newton, David T, Gunderman, David, Hutchins, Gary D

“…Positron emission tomography (PET) imaging enables quantitative assessment of tissue physiology. Dynamic pharmacokinetic analysis of PET images requires…”
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A Comparison of Arterial Input Function Interpolation Methods for Patlak Plot Analysis of 68Ga-PSMA-11 PET Prostate Cancer Studies by Smith, Nathaniel J., Newton, David T., Gunderman, David, Hutchins, Gary D.

“…Positron emission tomography (PET) imaging enables quantitative assessment of tissue physiology. Dynamic pharmacokinetic analysis of PET images requires…”
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Simple synthesis of carbon-11 labeled styryl dyes as new potential PET RNA-specific, living cell imaging probes by Wang, Min, Gao, Mingzhang, Miller, Kathy D., Sledge, George W., Hutchins, Gary D., Zheng, Qi-Huang

“…A new type of styryl dyes have been developed as RNA-specific, live cell imaging probes for fluorescent microscopy technology to study nuclear structure and…”
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Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor by Gao, Mingzhang, Wang, Min, Green, Mark A, Hutchins, Gary D, Zheng, Qi-Huang

“…The authentic standards GSK1482160 and its isomer, as well as the radiolabeling precursors desmethyl-GSK1482160 and Boc-protected desmethyl-GSK1482160 were…”
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A crosslinguistic PET study of tone perception by Gandour, J, Wong, D, Hsieh, L, Weinzapfel, B, Van Lancker, D, Hutchins, G D

“…In studies of pitch processing, a fundamental question is whether shared neural mechanisms at higher cortical levels are engaged for pitch perception of…”
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Measurement of cardiovascular function using a novel view-sharing PET reconstruction method and tracer kinetic analysis by Territo, Paul R., Riley, Amanda A., McCarthy, Brian P., Hutchins, Gary D.

“…Recent advancements in PET instrumentation have made the non-invasive assessment of cardiovascular function in small animals a reality. The majority of small…”
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Functional Heterogeneity of Inferior Frontal Gyrus Is Shaped by Linguistic Experience by Hsieh, Li, Gandour, Jack, Wong, Donald, Hutchins, Gary D.

“…A crosslinguistic, positron emission tomography (PET) study was conducted to determine the influence of linguistic experience on the perception of segmental…”
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Design and synthesis of carbon-11-labeled dual aromatase–steroid sulfatase inhibitors as new potential PET agents for imaging of aromatase and steroid sulfatase expression in breast cancer by Wang, Min, Mickens, Jarrett, Gao, Mingzhang, Miller, Kathy D., Sledge, George W., Hutchins, Gary D., Zheng, Qi-Huang

“…Aromatase and steroid sulfatase (STS) are particularly attractive targets in the treatment of estrogen-receptor-positive breast cancer and the development of…”
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