Evaluation of hepatocellular function by way of receptor-mediated uptake of a technetium-99m-labeled asialoglycoprotein analog

We have developed a quantitative functional imaging study of the liver using a radiolabeled asialoglycoprotein analog, Tc-galactosyl-neoglycoalbumin. Heart and liver time-activity data can be transformed by automated kinetic analysis into asialoglycoprotein hepatocyte receptor concentration. Twenty-...

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Bibliographic Details
Published in:	Hepatology (Baltimore, Md.) Vol. 20; no. 4 Pt 1; p. 917
Main Authors:	Pimstone, N R, Stadalnik, R C, Vera, D R, Hutak, D P, Trudeau, W L
Format:	Journal Article
Language:	English
Published:	United States 01-10-1994
Subjects:	Albumins - pharmacokinetics Aminopyrine Asialoglycoprotein Receptor Breath Tests Carbon Radioisotopes Chronic Disease Humans Indocyanine Green Liver - diagnostic imaging Liver - metabolism Liver - physiopathology Liver Cirrhosis, Biliary - diagnostic imaging Liver Cirrhosis, Biliary - metabolism Liver Cirrhosis, Biliary - physiopathology Liver Diseases - diagnostic imaging Liver Diseases - metabolism Liver Diseases - physiopathology Liver Function Tests - methods Organotechnetium Compounds - pharmacokinetics Predictive Value of Tests Radionuclide Imaging Receptors, Cell Surface - metabolism Sensitivity and Specificity
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Summary:	We have developed a quantitative functional imaging study of the liver using a radiolabeled asialoglycoprotein analog, Tc-galactosyl-neoglycoalbumin. Heart and liver time-activity data can be transformed by automated kinetic analysis into asialoglycoprotein hepatocyte receptor concentration. Twenty-eight healthy controls, 46 patients with noncholestatic chronic liver injury and 11 patients with primary biliary cirrhosis were studied. Liver function was also assessed by Pugh modified-Child-Turcotte criteria, 14C-aminopyrine breath test and indocyanine green clearance (24 patients). (a) In normal controls with a Child-Turcotte criteria score of 5, receptor concentration ranged from 0.63 to 1.19 mumol/L, with a mean 0.83 +/- 2 S.D. 0.06 mumol/L, which was significantly higher (p < 0.001) than that of the patient group (mean receptor concentration = 0.44 +/- 2 S.D. 0.04 mumol/L). In cirrhotic patients with Child-Turcotte criteria score of 5, the mean receptor concentration was 0.60 +/- 2 S.D. 0.07 mumol/L, which was significantly lower than controls (p < 0.01). In end-stage cirrhosis (Child-Turcotte criteria score 11 to 15), a group in which patients died or required orthotopic liver transplantation within 1 yr, the mean receptor concentration was 0.35 +/- 2 S.D. to 0.07 mumol/L. The sensitivity and specificity for receptor concentration in relation to liver disease, with values above 0.65 mumol/L being normal, were 0.96 and 0.88, respectively. Receptor concentration correlated well with Child-Turcotte criteria score (r = 0.78, p = < 0.001), with aminopyrine breath test (r = 0.75, p = < 0.001) and with indocyanine green clearance (r = 0.88, p = < 0.001).
ISSN:	0270-9139
DOI:	10.1002/hep.1840200421