Search Results - "Huston, Nicholas C"

Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms by Huston, Nicholas C., Wan, Han, Strine, Madison S., de Cesaris Araujo Tavares, Rafael, Wilen, Craig B., Pyle, Anna Marie

“…Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The…”
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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes by Ravindra, Neal G, Alfajaro, Mia Madel, Gasque, Victor, Huston, Nicholas C, Wan, Han, Szigeti-Buck, Klara, Yasumoto, Yuki, Greaney, Allison M, Habet, Victoria, Chow, Ryan D, Chen, Jennifer S, Wei, Jin, Filler, Renata B, Wang, Bao, Wang, Guilin, Niklason, Laura E, Montgomery, Ruth R, Eisenbarth, Stephanie C, Chen, Sidi, Williams, Adam, Iwasaki, Akiko, Horvath, Tamas L, Foxman, Ellen F, Pierce, Richard W, Pyle, Anna Marie, van Dijk, David, Wilen, Craig B

“…There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019…”
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Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis by Kardon, Julia R., Yien, Yvette Y., Huston, Nicholas C., Branco, Diana S., Hildick-Smith, Gordon J., Rhee, Kyu Y., Paw, Barry H., Baker, Tania A.

“…The mitochondrion maintains and regulates its proteome with chaperones primarily inherited from its bacterial endosymbiont ancestor. Among these chaperones is…”
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Sequencing and Structure Probing of Long RNAs Using MarathonRT: A Next-Generation Reverse Transcriptase by Guo, Li-Tao, Adams, Rebecca L., Wan, Han, Huston, Nicholas C., Potapova, Olga, Olson, Sara, Gallardo, Christian M., Graveley, Brenton R., Torbett, Bruce E., Pyle, Anna Marie

“…Reverse transcriptase (RT) enzymes are indispensable tools for interrogating diverse aspects of RNA metabolism and transcriptome composition. Due to the…”
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Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals by Grillo, Anthony S., SantaMaria, Anna M., Kafina, Martin D., Cioffi, Alexander G., Huston, Nicholas C., Han, Murui, Seo, Young Ah, Yien, Yvette Y., Nardone, Christopher, Menon, Archita V., Fan, James, Svoboda, Dillon C., Anderson, Jacob B., Hong, John D., Nicolau, Bruno G., Subedi, Kiran, Gewirth, Andrew A., Wessling-Resnick, Marianne, Kim, Jonghan, Paw, Barry H., Burke, Martin D.

“…Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in…”
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Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells by Tycko, Josh, Barrera, Luis A., Huston, Nicholas C., Friedland, Ari E., Wu, Xuebing, Gootenberg, Jonathan S., Abudayyeh, Omar O., Myer, Vic E., Wilson, Christopher J., Hsu, Patrick D.

“…Therapeutic genome editing with Staphylococcus aureus Cas9 (SaCas9) requires a rigorous understanding of its potential off-target activity in the human genome…”
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Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes by Seguin, Alexandra, Takahashi-Makise, Naoko, Yien, Yvette Y., Huston, Nicholas C., Whitman, Jared C., Musso, Gabriel, Wallace, Jared A., Bradley, Thomas, Bergonia, Hector A., Kafina, Martin D., Matsumoto, Mitsuyo, Igarashi, Kazuhiko, Phillips, John D., Paw, Barry H., Kaplan, Jerry, Ward, Diane M.

“…ATP-binding cassette subfamily B member 10 (Abcb10) is a mitochondrial ATP-binding cassette (ABC) transporter that complexes with mitoferrin1 and…”
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Publisher Correction: Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells by Tycko, Josh, Barrera, Luis A., Huston, Nicholas C., Friedland, Ari E., Wu, Xuebing, Gootenberg, Jonathan S., Abudayyeh, Omar O., Myer, Vic E., Wilson, Christopher J., Hsu, Patrick D.

“…The original HTML version of this Article incorrectly listed an affiliation of Josh Tycko as ‘Department of Genetics, Stanford University School of Medicine,…”
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Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression by Anderson, Heidi, Patch, Taylor C., Reddy, Pavankumar N.G., Hagedorn, Elliott J., Kim, Peter G., Soltis, Kathleen A., Chen, Michael J., Tamplin, Owen J., Frye, Maike, MacLean, Glenn A., Hübner, Kathleen, Bauer, Daniel E., Kanki, John P., Vogin, Guillaume, Huston, Nicholas C., Nguyen, Minh, Fujiwara, Yuko, Paw, Barry H., Vestweber, Dietmar, Zon, Leonard I., Orkin, Stuart H., Daley, George Q., Shah, Dhvanit I.

“…Rare endothelial cells in the aorta-gonad-mesonephros (AGM) transition into hematopoietic stem cells (HSCs) during embryonic development. Lineage tracing…”
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Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia by Shmukler, Boris E, Huston, Nicholas C, Thon, Jonathan N, Ni, Chih-Wen, Kourkoulis, George, Lawson, Nathan D, Paw, Barry H, Alper, Seth L

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The global and local distribution of RNA structure throughout the SARS-CoV-2 genome by Tavares, Rafael de Cesaris Araujo, Mahadeshwar, Gandhar, Wan, Han, Huston, Nicholas C, Pyle, Anna Marie

“…SARS-CoV-2 is the causative viral agent of COVID-19, the disease at the center of the current global pandemic. While knowledge of highly structured regions is…”
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The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles by Huston, Nicholas C, Tsao, Lucille H, Brackney, Doug E, Pyle, Anna Marie

“…West Nile virus (WNV) is an arthropod-borne, positive-sense RNA virus that poses an increasing global threat due to warming climates and lack of effective…”
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Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia by Crispin, Andrew, Guo, Chaoshe, Chen, Caiyong, Campagna, Dean R, Schmidt, Paul J, Lichtenstein, Daniel, Cao, Chang, Sendamarai, Anoop K, Hildick-Smith, Gordon J, Huston, Nicholas C, Boudreaux, Jeanne, Bottomley, Sylvia S, Heeney, Matthew M, Paw, Barry H, Fleming, Mark D, Ducamp, Sarah

“…The congenital sideroblastic anemias (CSAs) can be caused by primary defects in mitochondrial iron-sulfur (Fe-S) cluster biogenesis. HSCB (heat shock cognate…”
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The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability by Chung, Jacky, Bauer, Daniel E, Ghamari, Alireza, Nizzi, Christopher P, Deck, Kathryn M, Kingsley, Paul D, Yien, Yvette Y, Huston, Nicholas C, Chen, Caiyong, Schultz, Iman J, Dalton, Arthur J, Wittig, Johannes G, Palis, James, Orkin, Stuart H, Lodish, Harvey F, Eisenstein, Richard S, Cantor, Alan B, Paw, Barry H

“…In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are…”
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Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria by Chung, Jacky, Anderson, Sheila A., Gwynn, Babette, Deck, Kathryn M., Chen, Michael J., Langer, Nathaniel B., Shaw, George C., Huston, Nicholas C., Boyer, Leah F., Datta, Sumon, Paradkar, Prasad N., Li, Liangtao, Wei, Zong, Lambert, Amy J., Sahr, Kenneth, Wittig, Johannes G., Chen, Wen, Lu, Wange, Galy, Bruno, Schlaeger, Thorsten M., Hentze, Matthias W., Ward, Diane M., Kaplan, Jerry, Eisenstein, Richard S., Peters, Luanne L., Paw, Barry H.

“…Mitochondrial iron is essential for the biosynthesis of heme and iron-sulfur ([Fe-S]) clusters in mammalian cells. In developing erythrocytes, iron is imported…”
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Macrocytic Anemia and Mitochondriopathy Resulting from a Defect in Sideroflexin 4 by Hildick-Smith, Gordon J., Cooney, Jeffrey D., Garone, Caterina, Kremer, Laura S., Haack, Tobias B., Thon, Jonathan N., Miyata, Non, Lieber, Daniel S., Calvo, Sarah E., Akman, H. Orhan, Yien, Yvette Y., Huston, Nicholas C., Branco, Diana S., Shah, Dhvanit I., Freedman, Matthew L., Koehler, Carla M., Italiano, Joseph E., Merkenschlager, Andreas, Beblo, Skadi, Strom, Tim M., Meitinger, Thomas, Freisinger, Peter, Donati, M. Alice, Prokisch, Holger, Mootha, Vamsi K., DiMauro, Salvatore, Paw, Barry H.

“…We used exome sequencing to identify mutations in sideroflexin 4 (SFXN4) in two children with mitochondrial disease (the more severe case also presented with…”
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Identification of Guide-Intrinsic Determinants of Cas9 Specificity by Huston, Nicholas C, Tycko, Josh, Tillotson, Eric L, Wilson, Christopher J, Myer, Vic E, Jayaram, Hariharan, Steinberg, Barrett E

“…Considerable effort has been devoted to developing a comprehensive understanding of CRISPR nuclease specificity. predictions and multiple genome-wide cellular…”
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Sensitive detection of structural features and rearrangements in long, structured RNA molecules by Adams, Rebecca L, Huston, Nicholas C, Tavares, Rafael C A, Pyle, Anna M

“…Technical innovations in structural probing have drastically advanced the field of RNA structure analysis. These advances have led to parallel approaches…”
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Erythroid Cells Adapt to L-Leucine Scarcity By Reducing Hemoglobin Production Via the mTORC1/4E-BP Pathway by Chung, Jacky, Bauer, Daniel E., Ghamari, Alireza, Nizzi, Christopher P., Deck, Kathryn M., Kingsley, Paul D., Yien, Yvette Y., Huston, Nicholas C., Chen, Caiyong, Wittig, Johannes G., Palis, James, Orkin, Stuart H., Lodish, Harvey F., Eisenstein, Richard S., Cantor, Alan B., Paw, Barry H.

“…In multicellular organisms, the mechanisms by which diverse cell types acquire distinct amino acids and how cellular function adapts to their availability are…”
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Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria by Chung, Jacky, Anderson, Sheila A., Gwynn, Babette, Deck, Kathryn M., Chen, Michael J., Langer, Nathaniel B., Shaw, George C., Huston, Nicholas C., Boyer, Leah F., Datta, Sumon, Paradkar, Prasad N., Li, Liangtao, Wei, Zong, Lambert, Amy J., Sahr, Kenneth, Wittig, Johannes G., Chen, Wen, Lu, Wange, Galy, Bruno, Schlaeger, Thorsten M., Hentze, Matthias W., Ward, Diane M., Kaplan, Jerry, Eisenstein, Richard S., Peters, Luanne L., Paw, Barry H.

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