The effects of time restricted feeding on age-related changes in the mouse retina

The effects of time restricted feeding on age-related changes in the mouse retina

Dietary modifications such as caloric restriction (CR) and intermittent fasting (IF) have gained popularity due to their proven health benefits in aged populations. In time restricted feeding (TRF), a form of intermittent fasting, the amount of time for food intake is regulated without restricting t...

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Published in:Experimental gerontology Vol. 194; p. 112510
Main Authors: Huston, Cade A., Milan, Madison, Vance, Michaela L., Bickel, Marisa A., Miller, Lauren R., Negri, Sharon, Hibbs, Clara, Vaden, Hannah, Hayes, Lindsay, Csiszar, Anna, Ungvari, Zoltan, Yabluchanskiy, Andriy, Tarantini, Stefano, Conley, Shannon M.
Format: Journal Article
Language:English
Published: England Elsevier Inc 01-09-2024
Elsevier
Subjects:
Aging
Aging - physiology
Animals
Caloric Restriction
Electroretinography
Fasting - physiology
Intermittent Fasting
Male
Mice
Mice, Inbred C57BL
Retina
Retina - physiology
Time-restricted feeding
Vascular aging
Vascular aging
Aging
Time-restricted feeding
Retina
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Summary:Dietary modifications such as caloric restriction (CR) and intermittent fasting (IF) have gained popularity due to their proven health benefits in aged populations. In time restricted feeding (TRF), a form of intermittent fasting, the amount of time for food intake is regulated without restricting the caloric intake. TRF is beneficial for the central nervous system to support brain health in the context of aging. Therefore, we here ask whether TRF also exerts beneficial effects in the aged retina. We compared aged mice (24 months) on a TRF paradigm (access to food for six hours per day) for either 6 or 12 months against young control mice (8 months) and aged control mice on an ad libitum diet. We examined changes in the retina at the functional (electroretinography), structural (histology and fluorescein angiograms) and molecular (gene expression) level. TRF treatment showed amelioration of age-related reductions in both scotopic and photopic b-wave amplitudes suggesting benefits for retinal interneuron signaling. TRF did not affect age-related signs of retinal inflammation or microglial activation at either the molecular or histological level. Our data indicate that TRF helps preserve some aspects of retinal function that are decreased with aging, adding to our understanding of the health benefits that altered feeding patterns may confer. •Time-restricted feeding is a dietary intervention in which feeding time but not food quantity is restricted.•Time-restricted feeding is of interest as a dietary modification for promoting healthy aging.•Time-restricted feeding reduces age-related declines in retinal function.•Time-restricted feeding does not alter age-related signs of retinal inflammation.
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Conceptualization: AC, ZU, ST, AY, SMC, Formal Analysis: CAH, MLV, MAB, LRM, SMC, Funding Acquisition: AC, ZU, SMC, ST, Investigation: CAH, MM, MLV, MAB, LRM, SN, CH, HV, ST, SMC, Methodology: LH, SMC, ST, Project Administration: ST, SMC, Resources: LH, SMC, ST, Supervision: SMC, ST, Visualization: CAH, SMC, LH, Writing-Original Draft: CAH, SMC, Writing-Review and Editing: CAH, MM, MLV, MAB, LRM, SN, CH, HV, LH, AC, ZU, AY, ST, SMC
Author Contributions
ISSN:0531-5565
1873-6815
1873-6815
DOI:10.1016/j.exger.2024.112510