Search Results - "Hussmann, G. Patrick"

Expediting in vitro characterization of mRNA-based gene therapies via high-content fluorescent imaging by Vigil, Toriana N., Zhang-Hulsey, Diana, Santos, Jose Luis, Patrick Hussmann, G.

“…mRNA-based therapeutics have progressed significantly over the past decade and hold great potential to treat several diseases, including but not limited to…”
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Melanopsin mediates light-dependent relaxation in blood vessels by Sikka, Gautam, Hussmann, G. Patrick, Pandey, Deepesh, Cao, Suyi, Hori, Daijiro, Park, Jong Taek, Steppan, Jochen, Kim, Jae Hyung, Barodka, Viachaslau, Myers, Allen C., Santhanam, Lakshmi, Nyhan, Daniel, Halushka, Marc K., Koehler, Raymond C., Snyder, Solomon H., Shimoda, Larissa A., Berkowitz, Dan E.

“…Melanopsin (opsin4; Opn4), a non-image-forming opsin, has been linked to a number of behavioral responses to light, including circadian photo-entrainment,…”
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Multiplex Bioanalytical Methods for Comprehensive Characterization and Quantification of the Unique Complementarity-Determining-Region Deamidation of MEDI7247, an Anti-ASCT2 Pyrrolobenzodiazepine Antibody–Drug Conjugate by Huang, Yue, Yuan, Jiaqi, Mu, Ruipeng, Kubiak, Robert J, Ball, Kathryn, Cao, Mingyan, Hussmann, G. Patrick, de Mel, Niluka, Liu, Dengfeng, Roskos, Lorin K, Liang, Meina, Rosenbaum, Anton I

“…Deamidation, a common post-translational modification, may impact multiple physiochemical properties of a therapeutic protein. MEDI7247, a…”
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Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate by Cao, Mingyan, Hussmann, G. Patrick, Tao, Yeqing, O’Connor, Ellen, Parthemore, Conner, Zhang-Hulsey, Diana, Liu, Dengfeng, Jiao, Yang, Mel, Niluka de, Prophet, Meagan, Korman, Samuel, Sonawane, Jaytee, Grigoriadou, Christina, Huang, Yue, Umlauf, Scott, Chen, Xiaoyu

“…Asparagine deamidation is a post-translational modification (PTM) that converts asparagine residues into iso-aspartate and/or aspartate. Non-enzymatic…”
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A scalable and robust cationic lipid/polymer hybrid nanoparticle platform for mRNA delivery by Meyer, Randall A., Hussmann, G. Patrick, Peterson, Norman C., Santos, Jose Luis, Tuesca, Anthony D.

“…[Display omitted] mRNA based gene therapies hold the potential to treat multiple diseases with significant advantages over DNA based therapies, including rapid…”
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A single homogeneous assay for simultaneous measurement of bispecific antibody target binding by Christian, Elizabeth A., Hussmann, G. Patrick, Babu, Meghna, Prophet, Meagan, Mazor, Yariv, Chen, Weimin, Grigoriadou, Christina, Lin, Shihua

“…Bispecific antibodies (BsAbs) are engineered to simultaneously bind two different antigens, and offer promising clinical outcomes for various diseases. The…”
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A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo by Hussmann, G Patrick, Kellar, Kenneth J

“…We have developed a new radioligand binding assay method to measure the concentration of nonradiolabeled drugs in the brain ex vivo. This new method fuses the…”
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Chronic sazetidine‐A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain by Hussmann, G. Patrick, DeDominicis, Kristen E., Turner, Jill R., Yasuda, Robert P., Klehm, Jacquelyn, Forcelli, Patrick A., Xiao, Yingxian, Richardson, Janell R., Sahibzada, Niaz, Wolfe, Barry B., Lindstrom, Jon, Blendy, Julie A., Kellar, Kenneth J.

“…Chronic nicotine administration increases the density of brain α4β2* nicotinic acetylcholine receptors (nAChRs), which may contribute to nicotine addiction by…”
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Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain by Hussmann, G Patrick, Turner, Jill R, Lomazzo, Ermelinda, Venkatesh, Rashmi, Cousins, Vanessa, Xiao, Yingxian, Yasuda, Robert P, Wolfe, Barry B, Perry, David C, Rezvani, Amir H, Levin, Edward D, Blendy, Julie A, Kellar, Kenneth J

“…Chronic nicotine administration increases α4β2 neuronal nicotinic acetylcholine receptor (nAChR) density in brain. This up-regulation probably contributes to…”
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