Search Results - "Hussein, Hazem G. A"
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Molecular Docking and Molecular Dynamics Studies Reveal the Anticancer Potential of Medicinal-Plant-Derived Lignans as MDM2-P53 Interaction Inhibitors
Published in Molecules (Basel, Switzerland) (01-09-2023)“…The interaction between the tumor suppressor protein p53 and its negative regulator, the MDM2 oncogenic protein, has gained significant attention in cancer…”
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Marine-Derived Compounds for CDK5 Inhibition in Cancer: Integrating Multi-Stage Virtual Screening, MM/GBSA Analysis and Molecular Dynamics Investigations
Published in Metabolites (01-10-2023)“…Cyclin-dependent kinase 5 (CDK5) plays a crucial role in various biological processes, including immune response, insulin secretion regulation, apoptosis, DNA…”
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Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties
Published in Archives of microbiology (01-05-2024)“…Fungi are of considerable importance due to their capacity to biosynthesize various secondary metabolites with bioactive properties that draw high attention in…”
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Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii
Published in Marine drugs (05-08-2023)“…Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for…”
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Compilation of secondary metabolites produced by fungal strains identified as Aspergillus flavus var. oryzae (formerly Aspergillus oryzae), with a review of biotechnological applications, and computational studies of their anti-COVID-19 activity
Published in Mycological progress (01-12-2024)“…Aspergillus flavus var . oryzae (formerly Aspergillus oryzae ) ( Aspergillaceae , Eurotiales ) is one of the most significant filamentous fungi in terms of…”
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Fungal aromatic-bisabolane sesquiterpenoids—possible peptidylprolyl cis/trans isomerase (Pin1) inhibitors for cancer
Published in Mycological progress (01-12-2023)“…Marine fungi have been proven as potential sources of natural metabolites with significant bioactivities that have not been sufficiently explored. This…”
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Design of new Mcl-1 inhibitors for cancer using fragments hybridization, molecular docking, and molecular dynamics studies
Published in Journal of biomolecular structure & dynamics (14-11-2023)“…Apoptosis is a critical process that regulates cell survival and death and plays an essential role in cancer development. The Bcl-2 protein family, including…”
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Computational screening identifies depsidones as promising Aurora A kinase inhibitors: extra precision docking and molecular dynamics studies
Published in Network modeling and analysis in health informatics and bioinformatics (Wien) (09-04-2024)“…The Aurora kinases play crucial roles in regulating mitotic progression and have implications in various diseases, including cancer. In this study, we explored…”
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Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of IAspergillus sydowii/I
Published in Marine drugs (01-08-2023)“…Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for…”
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