Search Results - "Hussein, Deema"

Array expression meta-analysis of cancer stem cell genes identifies upregulation of PODXL especially in DCC low expression meningiomas by Schulten, Hans-Juergen, Hussein, Deema

“…Meningiomas are the most common intracranial tumors, with a subset of cases bearing a progressive phenotype. The DCC netrin 1 receptor (DCC) is a candidate…”
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Chitosan-Based Polymeric Nanoparticles as an Efficient Gene Delivery System to Cross Blood Brain Barrier: In Vitro and In Vivo Evaluations by Khan, Ishaq N, Navaid, Shiza, Waqar, Walifa, Hussein, Deema, Ullah, Najeeb, Khan, Muhammad Umar Aslam, Hussain, Zakir, Javed, Aneela

“…Significant progress has been made in the field of gene therapy, but effective treatments for brain tumors remain challenging due to their complex nature…”
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Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models by Schulten, Hans-Juergen, Al-Adwani, Fatima, Saddeq, Haneen A. Bin, Alkhatabi, Heba, Alganmi, Nofe, Karim, Sajjad, Hussein, Deema, Al-Ghamdi, Khalid B., Jamal, Awatif, Al-Maghrabi, Jaudah, Al-Qahtani, Mohammed H.

“…Mutations in isocitrate dehydrogenase 1 ( IDH1 ) and IDH2 are oncogenic drivers to a variable extent in several tumors, including gliomas, acute myeloid…”
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Comprehensive molecular biomarker identification in breast cancer brain metastases by Schulten, Hans-Juergen, Bangash, Mohammed, Karim, Sajjad, Dallol, Ashraf, Hussein, Deema, Merdad, Adnan, Al-Thoubaity, Fatma K, Al-Maghrabi, Jaudah, Jamal, Awatif, Al-Ghamdi, Fahad, Choudhry, Hani, Baeesa, Saleh S, Chaudhary, Adeel G, Al-Qahtani, Mohammed H

“…Breast cancer brain metastases (BCBM) develop in about 20-30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to…”
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Role of ATP-Binding Cassette Transporter Proteins in CNS Tumors: Resistance- Based Perspectives and Clinical Updates by Asif, M, Usman, M, Ayub, Shahid, Farhat, Sahar, Huma, Zilli, Ahmed, Jawad, Kamal, Mohammad A, Hussein, Deema, Javed, Aneela, Khan, Ishaq

“…Despite gigantic advances in medical research and development, chemotherapeutic resistance remains a major challenge in complete remission of CNS tumors. The…”
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Editorial: Advances in Cancer Stem Cell Biology by Hussein, Deema, Pires, Isabel M, Krause, Petra, Schulten, Hans-Juergen

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Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression by Schulten, Hans-Juergen, Hussein, Deema, Al-Adwani, Fatima, Karim, Sajjad, Al-Maghrabi, Jaudah, Al-Sharif, Mona, Jamal, Awatif, Al-Ghamdi, Fahad, Baeesa, Saleh S, Bangash, Mohammed, Chaudhary, Adeel, Al-Qahtani, Mohammed

“…Meningiomas are the most common primary brain tumors bearing in a minority of cases an aggressive phenotype. Although meningiomas are stratified according to…”
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Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression by Johnson, Victoria L, Scott, Maria I F, Holt, Sarah V, Hussein, Deema, Taylor, Stephen S

“…During mitosis, the recruitment of spindle-checkpoint-associated proteins to the kinetochore occurs in a defined order. The protein kinase Bub1 localizes to…”
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The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug resistance of recurrent glioblastoma: in situ and in vitro analyses by Hussein, Deema, Alsereihi, Reem, Salwati, Abdulla Ahmed A, Algehani, Rinad, Alhowity, Alazouf, Al-Hejin, Ahmed M, Schulten, Hans-Juergen, Baeesa, Saleh, Bangash, Mohammed, Alghamdi, Fahad, Cross, Richard, Al Zughaibi, Torki, Saka, Mohamad, Chaudhary, Adeel, Abuzenadah, Adel

“…Glioblastomas (GBs) are characterised as one of the most aggressive primary central nervous system tumours (CNSTs). Single-cell sequencing analysis identified…”
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In situ characterization of stem cells-like biomarkers in meningiomas by Alamir, Hanin, Alomari, Mona, Salwati, Abdulla Ahmed A, Saka, Mohamad, Bangash, Mohammed, Baeesa, Saleh, Alghamdi, Fahad, Carracedo, Angel, Schulten, Hans-Juergen, Chaudhary, Adeel, Abuzenadah, Adel, Hussein, Deema

“…Meningioma cancer stem cells (MCSCs) contribute to tumor aggressiveness and drug resistance. Successful therapies developed for inoperable, recurrent, or…”
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Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines by Khan, Ishaq, Baeesa, Saleh, Bangash, Mohammed, Schulten, Hans-Juergen, Alghamdi, Fahad, Qashqari, Hanadi, Madkhali, Nawal, Carracedo, Angel, Saka, Mohamad, Jamal, Awatif, Al-Maghrabi, Jaudah, AlQahtani, Mohammed, Al-Karim, Saleh, Damanhouri, Ghazi, Saini, Kulvinder, Chaudhary, Adeel, Abuzenadah, Adel, Hussein, Deema

“…Meningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) tumors worldwide. Up to 20% of grade I meningioma tumors…”
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Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis by Hussein, Deema, Taylor, Stephen S

“…Farnesyl transferase inhibitors induce G2/M cell cycle delays that cannot be explained by inhibition of the Ras GTPase. Recently, the kinetochore protein…”
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Chronic hypoxia promotes hypoxia-inducible factor-1α–dependent resistance to etoposide and vincristine in neuroblastoma cells by Hussein, Deema, Estlin, Edward J., Dive, Caroline, Makin, Guy W.J.

“…Hypoxia is widespread in solid tumors as a consequence of poorly structured tumor-derived neovasculature. Direct measurement of low oxygen levels in a range of…”
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Updates on Therapeutics in Clinical Trials for Spinal Cord Injuries: Key Translational Applications of Human Embryonic Stem Cells-Derived Neural Progenitors by Zeb, Habiba, Khan, Ishaq Nasib, Munir, Iqbal, Ramadan, Wafaa Saadeldin, Ahmad, Mian Afaq, Hussein, Deema, Kamal, Mohammad Amjad, Al Karim, Saleh

“…Injuries to the spinal cord often have devastating physiological impacts due to the organ's vital role in neuro-impulse communications between muscles and the…”
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Overlapping variants in the blood, tissues and cell lines for patients with intracranial meningiomas are predominant in stem cell-related genes by Hussein, Deema, Dallol, Ashraf, Quintas, Rita, Schulten, Hans-Juergen, Alomari, Mona, Baeesa, Saleh, Bangash, Mohammed, Alghamdi, Fahad, Khan, Ishaq, ElAssouli, M-Zaki Mustafa, Saka, Mohamad, Carracedo, Angel, Chaudhary, Adeel, Abuzenadah, Adel

“…Bulk tissue genomic analysis of meningiomas identified common somatic mutations, however, it often excluded blood-related variants. In contrast, genomic…”
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Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint by Holt, Sarah V, Vergnolle, Mailys A. S, Hussein, Deema, Wozniak, Marcin J, Allan, Victoria J, Taylor, Stephen S

“…Cenp-F is an unusual kinetochore protein in that it localizes to the nuclear matrix in interphase and the nuclear envelope at the G2/M transition; it is…”
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Breast cancer awareness and breast self-examination in Northern Saudi Arabia. A preliminary survey by Hussein, Deema M, Alorf, Sana H, Al-Sogaih, Yasmeen S, Alorf, Sheikha H, Alaskar, Reem S, Al-Mahana, Ashgan M, Alsalhowb, Waad F, Alibrahim, Anfal K, Saka, Mohamad Y, Alhazimi, Awdah M, Baghirova, Arzu, Hindawi, Salwa I

“…To elicit knowledge of breast cancer, perception of occurrence, and behavior in relation to breast self-examination (BSE). A cross-sectional survey was carried…”
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Public awareness of central nervous system tumors in the Kingdom of Saudi Arabia by Aljuhani, Shahad H, Bamaroof, Saja A, Alghamdi, Thoraya H, Almogbel, Alhanoof A, Alkhammash, Alhanof S, Alkhammash, Batool S, Bahusayn, Amjad A, Bangash, Mohamad H, Baeesa, Saleh S, Chaudhary, Adeel G, Abuzenadah, Adel M, Mirza, Ahmed A, Saka, Mohamad Y, Hussein, Deema M

“…To investigate individuals` knowledge about central nervous system tumors (CNST) signs and symptoms and risk factors, as well as their readiness to seek…”
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Epidemiological Trends of Histopathologically WHO Classified CNS Tumors in Developing Countries: Systematic Review by Khan, Ishaq, Bangash, Mohammed, Baeesa, Saleh, Jamal, Awatif, Carracedo, Angel, Alghamdi, Fahad, Qashqari, Hanadi, Abuzenadah, Adel, AlQahtani, Mohammed, Damanhouri, Ghazi, Chaudhary, Adeel, Hussein, Deema

“…Background: Many developing countries are lagging behind in reporting epidemiological data for individual central nervous system (CNS) tumors. This paper aimed…”
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d-δ-Tocotrienol-mediated suppression of the proliferation of human PANC-1, MIA PaCa-2, and BxPC-3 pancreatic carcinoma cells by Hussein, Deema, Mo, Huanbiao

“…The rate-limiting activity of the mevalonate pathway, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, provides intermediates essential for growth…”
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