Search Results - "Hussain, Suleman S"

Food-based natural products for cancer management: Is the whole greater than the sum of the parts? by Hussain, Suleman S, Kumar, Addanki P, Ghosh, Rita

“…Abstract The rise in cancer incidence and mortality in developing countries together with the human and financial cost of current cancer therapy mandates a…”
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Genomic Signatures in HPV-Associated Tumors by Hussain, Suleman S, Lundine, Devon, Leeman, Jonathan E, Higginson, Daniel S

“…Papillomaviruses dysregulate the G1/S cell cycle transition in order to promote DNA synthesis in S phase, which is a requirement for viral replication. The…”
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Human papillomavirus 16 promotes microhomology-mediated end-joining by Leeman, Jonathan E., Li, Yi, Bell, Andrew, Hussain, Suleman S., Majumdar, Rahul, Rong-Mullins, Xiaoqing, Blecua, Pedro, Damerla, Rama, Narang, Himanshi, Ravindran, Pavithran T., Lee, Nancy Y., Riaz, Nadeem, Powell, Simon N., Higginson, Daniel S.

“…Squamous cell carcinomas (SCCs) arising from aerodigestive or anogenital epithelium that are associated with the human papillomavirus (HPV) are far more…”
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Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer by Clark, Alison, Villarreal, Michelle R., Huang, Shih-Bo, Jayamohan, Sridharan, Rivas, Paul, Hussain, Suleman S., Ybarra, Meagan, Osmulski, Pawel, Gaczynska, Maria E., Shim, Eun Yong, Smith, Tyler, Gupta, Yogesh K., Yang, Xiaoyu, Delma, Caroline R., Natarajan, Mohan, Lai, Zhao, Wang, Li-Ju, Michalek, Joel E., Higginson, Daniel S., Ikeno, Yuji, Ha, Chul Soo, Chen, Yidong, Ghosh, Rita, Kumar, Addanki P.

“…In this study we have identified POLθ-S6K-p62 as a novel druggable regulator of radiation response in prostate cancer. Despite significant advances in…”
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Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell by Hussain, Suleman S, Majumdar, Rahul, Moore, Grace M, Narang, Himanshi, Buechelmaier, Erika S, Bazil, Maximilian J, Ravindran, Pavithran T, Leeman, Jonathan E, Li, Yi, Jalan, Manisha, Anderson, Kyrie S, Farina, Andrea, Soni, Rekha, Mohibullah, Neeman, Hamzic, Edin, Rong-Mullins, Xiaoqing, Sifuentes, Christopher, Damerla, Rama R, Viale, Agnes, Powell, Simon N, Higginson, Daniel S

“…Abstract Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and…”
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Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation by Hussain, Suleman S., Huang, Shih-Bo, Bedolla, Roble G., Rivas, Paul, Basler, Joseph W., Swanson, Gregory P., Hui-Ming Huang, Tim, Narayanasamy, Ganesh, Papanikolaou, Nikos, Miyamoto, Hiroshi, Yeh, I-Tien, Reddick, Robert L., Pollock, Brad H., Ghosh, Rita, Kumar, Addanki P.

“…Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation increases local control, toxicity hampers further…”
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Abstract 3047: Sensitization of prostate cancer to chemo-radiation by ribosomal protein S6 inhibition by Hussain, Suleman S., Livi, Carolina B., Papanikolaou, Nikos, Chan, Daniel C., Ghosh, Rita, Kumar, Addanki P.

“…Radiation Therapy (RT) is curative for most localized prostate cancer (PCA) patients, but is limited by dose-related toxicities and radioresistance…”
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Extracting the Benefit of Nexrutine® for Cancer Prevention by Hussain, Suleman S., Patel, Darpan, Ghosh, Rita, Kumar, Addanki P.

“…The current standard of care for prostate cancer includes hormone therapy, radiation therapy, and radical prostatectomy, each with its own set of undesirable…”
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Abstract PO-085: Therapeutic targeting of RPS6KB1/SQSTM1 axis to prevent biochemical recurrence by Kumar, Addanki P., Clark, Alison, Villarreal, Michelle R., Huang, Shih-Bo, Hussain, Suleman S., Yang, Xiaoyu, Bedolla, Roble G., Rivas, Paul, Jayamohan, Sridharan, Wang, Li-Ju, Chen, Yidong, Ezhilan, Caroline Xavier Paul, Natarajan, Mohan, Michalek, Joel E., Reddick, Robert, Miyamoto, Hiroshi, Ghosh, Rita

“…Radiation therapy (RT) is a standard treatment for organ confined prostate cancer (PCa). Given that both intrinsic and acquired resistance to radiation causes…”
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Restoration of Radiosensitivity by Downregulation of Ribosomal Protein S6 by Hussain, Suleman S, Papanikolaou, Nikos, Chan, Daniel C, Ghosh, Rita, Kumar, Addanki P

“…Abstract only Radiation Therapy (RT) is a curative treatment for localized prostate cancer (PCA), but is limited by dose‐related toxicities and…”
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Abstract 3943: Inhibition of ribosomal protein RPS6KB1 as a strategy to improve conventional therapy for prostate cancer by Clark, Alison D., Hussain, Suleman S., Huang, Shih-Bo, Bedolla, Roble G., Obeidat, Mohammad A., Papanikolaou, Niko, Lin, Chun Lin, Huang, Tim H., Gupta, Yogesh, Chen, Yidong, Miyamoto, Hiroshi, Ghosh, Rita, Kumar, Addanki P.

“…Radiation therapy (RT) is a standard treatment for organ confined prostate cancer (PCa). Although dose escalation increases local control, further escalation…”
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Abstract 3521: Non-canonical activation of AR signaling by histone deacetylase SIRT1 by Huang, Shih-Bo, Thapa, Dinesh, Hussain, Suleman S., Bedolla, Roble G., Li, Guiming, Reddick, Robert L., Lai, Zhao, Chen, Hung-I H., Chen, Yidong, Ghosh, Rita, Kumar, Addanki P.

“…SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, is a member of multigene family of Sirtuins. Traditionally SIRT1 is a known player in…”
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Abstract 1797: Downregulation of ribosomal protein S6 overcomes radioresistance in prostate cancer by Hussain, Suleman S., Rivas, Paul, Bedolla, Roble G., Papanikolaou, Nikos, Reddick, Robert L., Pollock, Brad H., Chan, Daniel C., Ghosh, Rita, Kumar, Addanki P.

“…Radiation Therapy (RT) is a definitive treatment for early-localized prostate cancer (PCA), but is associated with side effects which impair quality of life in…”
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Abstract 4: Intercepting ribosomal protein S6KB1 signaling: Prevention of prostate cancer recurrence by Kumar, Addanki Pratap, Clark, Alison, Villarreal, Michelle, Jayamohan, Sridharan, Huang, Shih-Bo, Hussain, Suleman S., Yang, Xiaoyu, Rivas, Paul, Patel, Darpan, Pierce, Bethany L., Tripathy, Shreya, Osmulski, Pawel, Gaczynska, Maria, Zhao, Lai, Wang, Li-Ju, Chen, Yidong, Ezhilan, Caroline Xavier Paul, Natarajan, Mohan, Michalek, Joel E., Reddick, Robert L., Ghosh, Rita

“…There is an urgent need for innovative strategies such as the discovery of adjuvants that can prevent relapse and improve quality of life for patients treated…”
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