Search Results - "Hussain, Sabah N."

Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging by Leduc-Gaudet, Jean-Philippe, Hussain, Sabah N. A., Barreiro, Esther, Gouspillou, Gilles

“…The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes,…”
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The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock by Shao, Wei, Yeretssian, Garabet, Doiron, Karine, Hussain, Sabah N., Saleh, Maya

“…Caspase-1 is an essential effector of inflammation, pyroptosis, and septic shock. Few caspase-1 substrates have been identified to date, and these substrates…”
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MYTHO is a novel regulator of skeletal muscle autophagy and integrity by Leduc-Gaudet, Jean-Philippe, Franco-Romero, Anais, Cefis, Marina, Moamer, Alaa, Broering, Felipe E., Milan, Giulia, Sartori, Roberta, Chaffer, Tomer Jordi, Dulac, Maude, Marcangeli, Vincent, Mayaki, Dominique, Huck, Laurent, Shams, Anwar, Morais, José A., Duchesne, Elise, Lochmuller, Hanns, Sandri, Marco, Hussain, Sabah N. A., Gouspillou, Gilles

“…Autophagy is a critical process in the regulation of muscle mass, function and integrity. The molecular mechanisms regulating autophagy are complex and still…”
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Role of autophagy in COPD skeletal muscle dysfunction by Hussain, Sabah N A, Sandri, Marco

“…Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by parenchymal damage and irreversible airflow limitation. In addition to lung…”
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Mechanical Ventilation-induced Diaphragm Disuse in Humans Triggers Autophagy by HUSSAIN, Sabah N. A, MOFARRAHI, Mahroo, DANIALOU, Gawiyou, MATECKI, Stefan, JABER, Samir, PETROF, Basil J, GOLDBERG, Peter, SIGALA, Ioanna, HO CHEOL KIM, VASSILAKOPOULOS, Theodoros, MALTAIS, Francois, BELLENIS, Ion, CHATURVEDI, Rakesh, GOTTFRIED, Stewart B, METRAKOS, Peter

“…Controlled mechanical ventilation (CMV) results in atrophy of the human diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle…”
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Autophagy and skeletal muscles in sepsis by Mofarrahi, Mahroo, Sigala, Ioanna, Guo, Yeting, Godin, Richard, Davis, Elaine C, Petrof, Basil, Sandri, Marco, Burelle, Yan, Hussain, Sabah N A

“…Mitochondrial injury develops in skeletal muscles during the course of severe sepsis. Autophagy is a protein and organelle recycling pathway which functions to…”
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An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease by Maltais, François, Decramer, Marc, Casaburi, Richard, Barreiro, Esther, Burelle, Yan, Debigaré, Richard, Dekhuijzen, P N Richard, Franssen, Frits, Gayan-Ramirez, Ghislaine, Gea, Joaquim, Gosker, Harry R, Gosselink, Rik, Hayot, Maurice, Hussain, Sabah N A, Janssens, Wim, Polkey, Micheal I, Roca, Josep, Saey, Didier, Schols, Annemie M W J, Spruit, Martijn A, Steiner, Michael, Taivassalo, Tanja, Troosters, Thierry, Vogiatzis, Ioannis, Wagner, Peter D

“…Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease (COPD) and it has important clinical implications, such as reduced exercise…”
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Autophagy in Locomotor Muscles of Patients with Chronic Obstructive Pulmonary Disease by GUO, Yeting, GOSKER, Harry R, HUSSAIN, Sabah N. A, SCHOLS, Annemie M. W. J, KAPCHINSKY, Sophia, BOURBEAU, Jean, SANDRI, Marco, JAGOE, R. Thomas, DEBIGARE, Richard, MALTAIS, François, TAIVASSALO, Tanja

“…Locomotor muscle atrophy develops in patients with chronic obstructive pulmonary disease (COPD) partly because of increased protein degradation by the…”
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Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study by Dos Santos, Claudia, Hussain, Sabah N A, Mathur, Sunita, Picard, Martin, Herridge, Margaret, Correa, Judy, Bain, Alexandra, Guo, Yeting, Advani, Andrew, Advani, Suzanne L, Tomlinson, George, Katzberg, Hans, Streutker, Catherine J, Cameron, Jill I, Schols, Annemie, Gosker, Harry R, Batt, Jane

“…Critical illness survivors often experience permanent functional disability due to intensive care unit (ICU)-acquired weakness. The mechanisms responsible for…”
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Failed reinnervation in aging skeletal muscle by Aare, Sudhakar, Spendiff, Sally, Vuda, Madhusudanarao, Elkrief, Daren, Perez, Anna, Wu, Qinghua, Mayaki, Dominique, Hussain, Sabah N A, Hettwer, Stefan, Hepple, Russell T

“…Skeletal muscle displays a marked accumulation of denervated myofibers at advanced age, which coincides with an acceleration of muscle atrophy. In this study,…”
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Reactive oxygen species regulation of autophagy in skeletal muscles by Rahman, Mashrur, Mofarrahi, Mahroo, Kristof, Arnold S, Nkengfac, Bernard, Harel, Sharon, Hussain, Sabah N A

“…To evaluate the effects of physiological levels of mitochondrial-derived reactive oxygen species (ROS) on skeletal muscle autophagy, a proteolytic pathway…”
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Effects of Controlled Mechanical Ventilation on Sepsis-Induced Diaphragm Dysfunction in Rats by Maes, Karen, Stamiris, Angela, Thomas, Debby, Cielen, Nele, Smuder, Ashley, Powers, Scott K, Leite, Felipe S, Hermans, Greet, Decramer, Marc, Hussain, Sabah N, Gayan-Ramirez, Ghislaine

“…OBJECTIVES:Diaphragm dysfunction develops during severe sepsis as a consequence of hemodynamic, metabolic, and intrinsic abnormalities. Similarly, 12 hours of…”
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Genetic and histologic evidence for autophagy in asthma pathogenesis by Poon, Audrey H., PhD, Chouiali, Fazila, MSc, Tse, Sze Man, MDCM, Litonjua, Augusto A., MD, MPH, Hussain, Sabah N.A., MD, PhD, Baglole, Carolyn J., PhD, Eidelman, David H., MD, Olivenstein, Ronald, MD, Martin, James G., MD, DSc, Weiss, Scott T., MD, MS, Hamid, Qutayba, MD, PhD, Laprise, Catherine, PhD

“…Exhaled levels of mediators associated with ROS positively correlate with asthma severity.1 Autophagy, the process of cellular waste disposal through…”
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Mechanical ventilation causes diaphragm dysfunction in newborn lambs by Liang, Feng, Emeriaud, Guillaume, Rassier, Dilson E, Shang, Dong, Gusev, Ekaterina, Hussain, Sabah N A, Sage, Michael, Crulli, Benjamin, Fortin-Pellerin, Etienne, Praud, Jean-Paul, Petrof, Basil J

“…Diaphragm weakness occurs rapidly in adult animals treated with mechanical ventilation (MV), but the effects of MV on the neonatal diaphragm have not been…”
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Angiopoietin-1 enhances skeletal muscle regeneration in mice by Mofarrahi, Mahroo, McClung, Joseph M, Kontos, Christopher D, Davis, Elaine C, Tappuni, Bassman, Moroz, Nicolay, Pickett, Amy E, Huck, Laurent, Harel, Sharon, Danialou, Gawiyou, Hussain, Sabah N A

“…Activation of muscle progenitor cell myogenesis and endothelial cell angiogenesis is critical for the recovery of skeletal muscle from injury. Angiopoietin-1…”
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Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells by Chan, Wilson, Ismail, Hodan, Mayaki, Dominique, Sanchez, Veronica, Tiedemann, Kerstin, Davis, Elaine C, Hussain, Sabah N A

“…Fibulin-5 is an extracellular matrix glycoprotein that plays critical roles in vasculogenesis and embryonic development. Deletion of Fibulin-5 in mice results…”
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Differential Regulation of the Autophagy and Proteasome Pathways in Skeletal Muscles in Sepsis by Stana, Flavia, Vujovic, Marija, Mayaki, Dominique, Leduc-Gaudet, Jean-Philippe, Leblanc, Philippe, Huck, Laurent, Hussain, Sabah N. A.

“…OBJECTIVES:Skeletal muscle fiber atrophy develops in response to severe sepsis, but it is unclear as to how the proteolytic pathways that are involved in its…”
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Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis by Fielhaber, Jill A, Carroll, Scott F, Dydensborg, Anders B, Shourian, Mitra, Triantafillopoulos, Alexandra, Harel, Sharon, Hussain, Sabah N, Bouchard, Maxime, Qureshi, Salman T, Kristof, Arnold S

“…Acute lung injury during bacterial infection is associated with neutrophilic inflammation, epithelial cell apoptosis, and disruption of the alveolar-capillary…”
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NOX2, NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in endothelial cells by Harel, Sharon, Mayaki, Dominique, Sanchez, Veronica, Hussain, Sabah N.A

“…Abstract Angiopoietin-1 (Ang-1) is a ligand of Tie-2 receptors that promotes survival, migration, and differentiation of endothelial cells. Several studies…”
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Autophagic flux and oxidative capacity of skeletal muscles during acute starvation by Mofarrahi, Mahroo, Guo, Yeting, Haspel, Jeffrey A, Choi, Augustine MK, Davis, Elaine C, Gouspillou, Gilles, Hepple, Russell T, Godin, Richard, Burelle, Yan, Hussain, Sabah NA

“…Autophagy is an important proteolytic pathway in skeletal muscles. The roles of muscle fiber type composition and oxidative capacity remain unknown in relation…”
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