Search Results - "Hussain, S Farzana"

A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients by FARZANA HUSSAIN, S, KONG, Ling-Yuan, JORDAN, Justin, CONRAD, Charles, MADDEN, Timothy, FOKT, Isabella, PRIEBE, Waldemar, HEIMBERGER, Amy B

“…Overcoming the profound immunosuppression in patients with solid cancers has impeded efficacious immunotherapy. Signal transducers and activators of…”
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Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy by Jordan, Justin T., Sun, Wei, Hussain, S. Farzana, DeAngulo, Guillermo, Prabhu, Sujit S., Heimberger, Amy B.

“…Despite the immunogenicity of glioblastoma multiforme (GBM), immune-mediated eradication of these tumors remains deficient. Regulatory T cells (Tregs) in the…”
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Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia by Murat, Anastasia, Migliavacca, Eugenia, Hussain, S Farzana, Heimberger, Amy B, Desbaillets, Isabelle, Hamou, Marie-France, Rüegg, Curzio, Stupp, Roger, Delorenzi, Mauro, Hegi, Monika E

“…Glioblastoma are rapidly proliferating brain tumors in which hypoxia is readily recognizable, as indicated by focal or extensive necrosis and vascular…”
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Innate immune functions of microglia isolated from human glioma patients by Hussain, S Farzana, Yang, David, Suki, Dima, Grimm, Elizabeth, Heimberger, Amy B

“…Innate immunity is considered the first line of host defense and microglia presumably play a critical role in mediating potent innate immune responses to…”
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The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses by Hussain, S Farzana, Yang, David, Suki, Dima, Aldape, Kenneth, Grimm, Elizabeth, Heimberger, Amy B

“…Little is known about the immune performance and interactions of CNS microglia/macrophages in glioma patients. We found that microglia/macrophages were the…”
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What is needed for effective antitumor immunotherapy? Lessons learned using Listeria monocytogenes as a live vector for HPV-associated tumors by Hussain, S Farzana, Paterson, Yvonne

“…As a vaccine vector, Listeria monocytogenes targets the innate immune system, resulting in a cytokine response that enhances antigen-presenting cell function…”
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Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study by Heimberger, Amy B, Sun, Wei, Hussain, S Farzana, Dey, Mahua, Crutcher, Lamonne, Aldape, Ken, Gilbert, Mark, Hassenbusch, Samuel J, Sawaya, Raymond, Schmittling, Bob, Archer, Gary E, Mitchell, Duane A, Bigner, Darell D, Sampson, John H

“…Cytotoxic chemotherapy that induces lymphopenia is predicted to ablate the benefits of active antitumor immunization. Temozolomide is an effective…”
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Active Immunotherapy Combined With Blockade of a Coinhibitory Pathway Achieves Regression of Large Tumor Masses in Cancer-prone Mice by Lasaro, Marcio O, Sazanovich, Marina, Giles-Davis, Wynetta, Mrass, Paulus, Bunte, Ralph M, Sewell, Duane A, Hussain, S Farzana, Fu, Yang-Xin, Weninger, Wolfgang, Paterson, Yvonne, Ertl, Hildegund CJ

“…Vaccines that aim to expand tumor-specific CD8+ T cells have yielded disappointing results in cancer patients although they showed efficacy in transplantable…”
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CD4+CD25+ regulatory T cells that secrete TGFβ and IL-10 are preferentially induced by a vaccine vector by FARZANA HUSSAIN, S, PATERSON, Yvonne

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Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer by Souders, Nicholas C, Sewell, Duane A, Pan, Zhen-Kun, Hussain, S Farzana, Rodriguez, Alexander, Wallecha, Anu, Paterson, Yvonne

“…We have created a transgenic mouse with tissue-specific expression of the human papilloma virus (HPV) 16 E6 and E7 oncoproteins in the thyroid as a model of…”
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The Ability of Two Listeria monocytogenes Vaccines Targeting Human Papillomavirus-16 E7 to Induce an Antitumor Response Correlates with Myeloid Dendritic Cell Function by Peng, Xiaohui, Hussain, S. Farzana, Paterson, Yvonne

“…Previous work from our laboratory has shown that Lm-LLO-E7 induces complete regression of approximately 75% of established TC-1 tumors, whereas Lm-E7 only…”
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Immunotherapy for human glioma: innovative approaches and recent results by Hussain, S Farzana, Heimberger, Amy B

“…The outcome for malignant glioma patients remains dismal despite treatment with surgical resection, radiation and chemotherapy. The goal of immunotherapy is to…”
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Differential SLP-76 Expression and TCR-Mediated Signaling in Effector and Memory CD4 T Cells by Hussain, S. Farzana, Anderson, Charles F, Farber, Donna L

“…We present in this study novel findings on TCR-mediated signaling in naive, effector, and memory CD4 T cells that identify critical biochemical markers to…”
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Preferential migration of regulatory T cells mediated by gliomasecreted chemokines can be blocked with chemotherapy by Jordan, Justin T., Sun, Wei, Hussain, S. Farzana, DeAngulo, Guillermo, Prabhu, Sujit S., Heimberger, Amy B.

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The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses1 by Hussain, S. Farzana, Yang, David, Suki, Dima, Aldape, Kenneth, Grimm, Elizabeth, Heimberger, Amy B.

“…Little is known about the immune performance and interactions of CNS microglia/macrophages in glioma patients. We found that microglia/macrophages were the…”
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Heterogeneity of the Memory CD4 T Cell Response: Persisting Effectors and Resting Memory T Cells by Ahmadzadeh, Mojgan, Hussain, S. Farzana, Farber, Donna L

“…Defining the cellular composition of the memory T cell pool has been complicated by an inability to distinguish effector and memory T cells. We present here an…”
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CD4+CD25+ regulatory T cells that secrete TGFbeta and IL-10 are preferentially induced by a vaccine vector by Hussain, S Farzana, Paterson, Yvonne

“…CD4CD25 T cells generated in a vaccine scenario can play a critical role in limiting antitumor therapy, thus having widespread implications for the…”
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Effector CD4 T Cells Are Biochemically Distinct from the Memory Subset: Evidence for Long-Term Persistence of Effectors In Vivo by Ahmadzadeh, Mojgan, Hussain, S. Farzana, Farber, Donna L

“…Memory T cell responses are believed to be mediated by long-lived memory T cells that arise directly from a subset of short-lived, activated effector T cells…”
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