Search Results - "Hussain, Munir A."

Drug-polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development by Qian, Feng, Huang, Jun, Hussain, Munir A

“…Drug-polymer solid dispersion has been demonstrated as a feasible approach to formulate poorly water-soluble drugs in the amorphous form, for the enhancement…”
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Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type by Jackson, Matthew J, Kestur, Umesh S, Hussain, Munir A, Taylor, Lynne S

“…Amorphous solid dispersions (ASDs) are of great interest as enabling formulations because of their ability to increase the bioavailability of poorly soluble…”
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Impact of Polymers on the Precipitation Behavior of Highly Supersaturated Aqueous Danazol Solutions by Jackson, Matthew J, Toth, Scott J, Kestur, Umesh S, Huang, Jun, Qian, Feng, Hussain, Munir A, Simpson, Garth J, Taylor, Lynne S

“…The phase behavior of supersaturated solutions of a relatively hydrophobic drug, danazol, was studied in the absence and presence of polymeric additives. To…”
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pH-dependent dissolution in vitro and absorption in vivo of weakly basic drugs: development of a canine model by Zhou, Rong, Moench, Paul, Heran, Christopher, Lu, Xujin, Mathias, Neil, Faria, Teresa N, Wall, Doris A, Hussain, Munir A, Smith, Ronald L, Sun, Duxin

“…The aim of this research was to develop a pH-dependent canine absorption model for studying pH effect on both dissolution in vitro and pharmacokinetics in vivo…”
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A study on the effect of wet granulation on microcrystalline cellulose particle structure and performance by FARAG BADAWY, Sherif I, GRAY, David B, HUSSAIN, Munir A

“…The aim of this study was to investigate the mechanism of the effect of wet granulation process on the compaction properties of microcrystalline cellulose…”
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Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389 by FARAG BADAWY, Sherif I, GRAY, David B, FANG ZHAO, DUXIN SUN, SCHUSTER, Alan E, HUSSAIN, Munir A

“…The purpose of the study was to investigate the specific mechanism by which elevated gastric pH reduces the absorption of BMS-561389, a factor Xa inhibitor,…”
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Characterization of Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions by Jackson, Matthew J., Kestur, Umesh S., Hussain, Munir A., Taylor, Lynne S.

“…ABSTRACT Purpose Excipients are essential for solubility enhancing formulations. Hence it is important to understand how additives impact key solution…”
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Pharmaceutical development and regulatory considerations for nanoparticles and nanoparticulate drug delivery systems by Narang, Ajit S, Chang, Rong-Kun, Hussain, Munir A

“…Pharmaceutical nanomaterials (NMs) encompass a wide variety of materials including drug nanoparticles (NPs), which can be amorphous or crystalline; or…”
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Non-invasive systemic drug delivery: developability considerations for alternate routes of administration by Mathias, Neil R, Hussain, Munir A

“…Over the past few decades alternate routes of administration have gained significant momentum and attention, to complement approved drug products, or enable…”
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Rat nasal lavage biomarkers to assess preclinical irritation potential of nasal drug formulations and excipients by Mathias, Neil R, Moench, Paul, Heran, Christopher, Hussain, Munir A, Smith, Ronald L

“…The goal of this study was to evaluate biomarkers of nasal mucosal damage for rapid assessment of irritancy potential of formulations in the rat nasal lavage…”
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Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders by Shah, Umang V., Wang, Zihua, Olusanmi, Dolapo, Narang, Ajit S., Hussain, Munir A., Tobyn, Michael J., Heng, Jerry Y.Y.

“…[Display omitted] Particle bulk and surface properties are influenced by the powder processing routes. This study demonstrates the effect of milling…”
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Microenvironmental pH modulation in solid dosage forms by Badawy, Sherif I Farag, Hussain, Munir A

“…There are many reports in the literature referring to the effect of microenvironmental pH on solid dosage form performance, particularly stability and…”
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Biopharmaceutical Evaluation and CMC Aspects of Oral Modified Release Formulations by Chang, Rong-Kun, Mathias, Neil, Hussain, Munir A.

“…This article discusses the range of outcomes from biopharmaceutical studies of specific modified release (MR) product examples in preclinical models and…”
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Effect of crystal habits on the surface energy and cohesion of crystalline powders by Shah, Umang V., Olusanmi, Dolapo, Narang, Ajit S., Hussain, Munir A., Gamble, John F., Tobyn, Michael J., Heng, Jerry Y.Y.

“…[Display omitted] The role of surface properties, influenced by particle processing, in particle–particle interactions (powder cohesion) is investigated in…”
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Ion-exchange resins as drug delivery carriers by Guo, Xiaodi, Chang, Rong-Kun, Hussain, Munir A

“…There are many reports in the literature referring to the utilization of drug bound to ion-exchange resin (drug-resinate), especially in the drug delivery…”
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Effect of starting material particle size on its agglomeration behavior in high shear wet granulation by Badawy, Sherif I Farag, Hussain, Munir A

“…The effect of anhydrous lactose particle size distribution on its performance in the wet granulation process was evaluated. Three grades of anhydrous lactose…”
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Decoupling the contribution of dispersive and acid-base components of surface energy on the cohesion of pharmaceutical powders by Shah, Umang V., Olusanmi, Dolapo, Narang, Ajit S., Hussain, Munir A., Tobyn, Michael J., Heng, Jerry Y.Y.

“…[Display omitted] This study reports an experimental approach to determine the contribution from two different components of surface energy on cohesion. A…”
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Measuring the sticking of mefenamic acid powders on stainless steel surface by Wang, Zihua, Shah, Umang V., Olusanmi, Dolapo, Narang, Ajit S., Hussain, Munir A., Gamble, John F., Tobyn, Michael J., Heng, Jerry Y.Y.

“…[Display omitted] This study proposes an approach for quantifying the amount of pharmaceutical powder adhering (quality attribute) to the metals surfaces. The…”
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Decoupling the Contribution of Surface Energy and Surface Area on the Cohesion of Pharmaceutical Powders by Shah, Umang V., Olusanmi, Dolapo, Narang, Ajit S., Hussain, Munir A., Tobyn, Michael J., Hinder, Steve J., Heng, Jerry Y. Y.

“…ABSTRACT Purpose Surface area and surface energy of pharmaceutical powders are affected by milling and may influence formulation, performance and handling…”
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Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms of BMS-779788 by Adams, Monica L, Sharma, Vijayata, Gokhale, Madhushree, Huang, Yande, Stefanski, Kevin, Su, Ching, Hussain, Munir A

“…BMS-779788 contains a reactive tertiary hydroxyl attached to a weakly basic imidazole ring. Propensity of the carbinol toward dehydration to yield the…”
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