Search Results - "Huso, David. L."

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells by Chung, Liam, Thiele Orberg, Erik, Geis, Abby L., Chan, June L., Fu, Kai, DeStefano Shields, Christina E., Dejea, Christine M., Fathi, Payam, Chen, Jie, Finard, Benjamin B., Tam, Ada J., McAllister, Florencia, Fan, Hongni, Wu, Xinqun, Ganguly, Sudipto, Lebid, Andriana, Metz, Paul, Van Meerbeke, Sara W., Huso, David L., Wick, Elizabeth C., Pardoll, Drew M., Wan, Fengyi, Wu, Shaoguang, Sears, Cynthia L., Housseau, Franck

“…Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using…”
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Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma by Gerber, Elizabeth E., Gallo, Elena M., Fontana, Stefani C., Davis, Elaine C., Wigley, Fredrick M., Huso, David L., Dietz, Harry C.

“…Failure of integrin-mediated cell-matrix attachment is sufficient to initiate dermal fibrosis and autoimmunity in mouse models of scleroderma;…”
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Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis by Goodwin, Andrew C, Shields, Christina E. Destefano, Wu, Shaoguang, Huso, David L, Wu, XinQun, Murray-Stewart, Tracy R, Hacker-Prietz, Amy, Rabizadeh, Shervin, Woster, Patrick M, Sears, Cynthia L, Casero, Robert A. Jr

“…It is estimated that the etiology of 20–30% of epithelial cancers is directly associated with inflammation, although the direct molecular events linking…”
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HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells by Shah, Sandeep N, Cope, Leslie, Poh, Weijie, Belton, Amy, Roy, Sujayita, Talbot, Jr, C Conover, Sukumar, Saraswati, Huso, David L, Resar, Linda M S

“…Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process…”
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A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome by Benjamin, Joel S., Pilarowski, Genay O., Carosso, Giovanni A., Zhang, Li, Huso, David. L., Goff, Loyal A., Vernon, Hilary J., Hansen, Kasper D., Bjornsson, Hans T.

“…Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin…”
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HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells by Belton, Amy, Gabrovsky, Alexander, Bae, Young Kyung, Reeves, Ray, Iacobuzio-Donahue, Christine, Huso, David L, Resar, Linda M S

“…Although metastatic colon cancer is a leading cause of cancer death worldwide, the molecular mechanisms that enable colon cancer cells to metastasize remain…”
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Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease by Cebotaru, Liudmila, Liu, Qiangni, Yanda, Murali K, Boinot, Clement, Outeda, Patricia, Huso, David L, Watnick, Terry, Guggino, William B, Cebotaru, Valeriu

“…Abnormal proliferation of cyst-lining epithelium and increased intracystic fluid secretion via the cystic fibrosis transmembrane conductance regulator (CFTR)…”
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Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis by Housseau, Franck, Wu, Shaoguang, Wick, Elizabeth C, Fan, Hongni, Wu, Xinqun, Llosa, Nicolas J, Smith, Kellie N, Tam, Ada, Ganguly, Sudipto, Wanyiri, Jane W, Iyadorai, Thevambiga, Malik, Ausama A, Roslani, April C, Vadivelu, Jamunarani S, Van Meerbeke, Sara, Huso, David L, Pardoll, Drew M, Sears, Cynthia L

“…IL17-producing Th17 cells, generated through a STAT3-dependent mechanism, have been shown to promote carcinogenesis in many systems, including microbe-driven…”
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HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche by Xian, Lingling, Georgess, Dan, Huso, Tait, Cope, Leslie, Belton, Amy, Chang, Yu-Ting, Kuang, Wenyong, Gu, Qihua, Zhang, Xiaoyan, Senger, Stefania, Fasano, Alessio, Huso, David L., Ewald, Andrew J., Resar, Linda M. S.

“…High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was…”
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Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development by Outeda, Patricia, Huso, David L., Fisher, Steven A., Halushka, Marc K., Kim, Hyunho, Qian, Feng, Germino, Gregory G., Watnick, Terry

“…Autosomal dominant polycystic kidney disease is a common form of inherited kidney disease that is caused by mutations in two genes, PKD1 (polycystin-1) and…”
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Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome by Habashi, Jennifer P, Judge, Daniel P, Holm, Tammy M, Cohn, Ronald D, Loeys, Bart L, Cooper, Timothy K, Myers, Loretha, Klein, Erin C, Liu, Guosheng, Calvi, Carla, Podowski, Megan, Neptune, Enid R, Halushka, Marc K, Bedja, Djahida, Gabrielson, Kathleen, Rifkin, Daniel B, Carta, Luca, Ramirez, Francesco, Huso, David L, Dietz, Harry C

“…Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected…”
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HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks by Shah, Sandeep N, Kerr, Candace, Cope, Leslie, Zambidis, Elias, Liu, Cyndi, Hillion, Joelle, Belton, Amy, Huso, David L, Resar, Linda M S

“…Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal…”
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Pericytes promote selective vessel regression to regulate vascular patterning by Simonavicius, Nicole, Ashenden, Matthew, van Weverwijk, Antoinette, Lax, Siân, Huso, David L., Buckley, Christopher D., Huijbers, Ivo J., Yarwood, Helen, Isacke, Clare M.

“…Blood vessel networks form in a 2-step process of sprouting angiogenesis followed by selective branch regression and stabilization of remaining vessels…”
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nanoparticle formulation that selectively transfects metastatic tumors in mice by Yang, Jian, Hendricks, William, Liu, Guosheng, McCaffery, J. Michael, Kinzler, Kenneth W., Huso, David L., Vogelstein, Bert, Zhou, Shibin

“…Nanoparticle gene therapy holds great promise for the treatment of malignant disease in light of the large number of potent, tumor-specific therapeutic…”
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Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation by Ericson, Kajsa, Gan, Christine, Cheong, Ian, Rago, Carlo, Samuels, Yardena, Velculescu, Victor E, Kinzler, Kenneth W, Huso, David L, Vogelstein, Bert, Papadopoulos, Nickolas

“…Phosphotidylinositol-3-kinase (PI3K) signaling is altered in the majority of human cancers. To gain insight into the roles of members of this pathway in growth…”
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Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice by Rhee, Ki-Jong, Wu, Shaoguang, Wu, XinQun, Huso, David L, Karim, Baktiar, Franco, Augusto A, Rabizadeh, Shervin, Golub, Jonathan E, Mathews, Lauren E, Shin, Jai, Sartor, R. Balfour, Golenbock, Douglas, Hamad, Abdel R, Gan, Christine M, Housseau, Franck, Sears, Cynthia L

“…Enterotoxigenic Bacteroides fragilis (ETBF) causes diarrhea and is implicated in inflammatory bowel diseases and colorectal cancer. The only known ETBF…”
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Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2‐deficient mice upon dextran sulfate treatment by Osburn, William O., Karim, Baktiar, Dolan, Patrick M., Liu, Guosheng, Yamamoto, Masayuki, Huso, David L., Kensler, Thomas W.

“…Chronic inflammation has been associated with increased risk of developing cancer. The transcription factor NF‐E2‐related factor 2 (Nrf2) controls the…”
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Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia by Lim, Yiting, Gondek, Lukasz, Li, Li, Wang, Qiuju, Ma, Hayley, Ma, Haley, Chang, Emily, Huso, David L, Foerster, Sarah, Marchionni, Luigi, McGovern, Karen, Watkins, David Neil, Peacock, Craig D, Levis, Mark, Smith, Bruce Douglas, Merchant, Akil A, Small, Donald, Matsui, William

“…FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations resulting in constitutive kinase activity are common in acute myeloid leukemia…”
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FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice by Bailey, Emily, Li Lia, Duffield, Amy S., Ma, Hayley S., Huso, David L., Small, Don

“…FMS-like tyrosine kinase 3 (FLT3) is mutated in approximately one third of acute myeloid leukemia cases. The most common FLT3 mutations in acute myeloid…”
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HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis by Schuldenfrei, Andrew, Belton, Amy, Kowalski, Jeanne, Talbot, Jr, C Conover, Di Cello, Francescopaolo, Poh, Weijie, Tsai, Hua-Ling, Shah, Sandeep N, Huso, Tait H, Huso, David L, Resar, Linda M S

“…Although the high mobility group A1 (HMGA1) gene is widely overexpressed in diverse cancers and portends a poor prognosis in some tumors, the molecular…”
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