Search Results - "Huso, D."

Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis by Shriver, M, Stroka, K M, Vitolo, M I, Martin, S, Huso, D L, Konstantopoulos, K, Kontrogianni-Konstantopoulos, A

“…Obscurins, encoded by the single OBSCN gene, are giant cytoskeletal proteins with structural and regulatory roles. The OBSCN gene is highly mutated in…”
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Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways by Wang, P, Chen, S-H, Hung, W-C, Paul, C, Zhu, F, Guan, P-P, Huso, D L, Kontrogianni-Konstantopoulos, A, Konstantopoulos, K

“…Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways…”
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PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis by Rybanska, I, Ishaq, O, Chou, J, Prakash, M, Bakhsheshian, J, Huso, D L, Franco, S

“…Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset…”
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Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture by Wang, Y., Huso, D.L., Harrington, J., Kellner, J., Jeong, D.K., Turney, J., McNiece, I.K.

“…Human mesenchymal stem cells (hMSC) have been isolated and characterized extensively for a variety of clinical applications. Yet it is unclear how the…”
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Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey by Park, J T, Johnson, N, Liu, S, Levesque, M, Wang, Y J, Ho, H, Huso, D, Maitra, A, Parsons, M J, Prescott, J D, Leach, S D

“…Somatic activation of the KRAS proto-oncogene is evident in almost all pancreatic cancers, and appears to represent an initiating event. These mutations occur…”
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An HIV-1 Transgenic Rat That Develops HIV-Related Pathology and Immunologic Dysfunction by Reid, W., Sadowska, M., Denaro, F., Rao, S., Foulke, J., Hayes, N., Jones, O., Doodnauth, D., Davis, H., Sill, A., O'Driscoll, P., Huso, D., Fouts, T., Lewis, G., Hill, M., Kamin-Lewis, R., Wei, C., Ray, P., Gallo, R. C., Reitz, M., Bryant, J.

“…We report, to our knowledge, the first HIV type 1 (HIV-1) transgenic (Tg) rat. Expression of the transgene, consisting of an HIV-1 provirus with a functional…”
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Loss of a single Hic1 allele accelerates polyp formation in ApcΔ716 mice by Mohammad, H P, Zhang, W, Prevas, H S, Leadem, B R, Zhang, M, Herman, J G, Hooker, C M, Watkins, D N, Karim, B, Huso, D L, Baylin, S B

“…Adenomatous polyposis coli ( APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with…”
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Mutant PIK3CA promotes cell growth and invasion of human cancer cells by Samuels, Yardena, Diaz, Luis A., Schmidt-Kittler, Oleg, Cummins, Jordan M., DeLong, Laura, Cheong, Ian, Rago, Carlo, Huso, David L., Lengauer, Christoph, Kinzler, Kenneth W., Vogelstein, Bert, Velculescu, Victor E.

“…PIK3CA is mutated in diverse human cancers, but the functional effects of these mutations have not been defined. To evaluate the consequences of PIK3CA…”
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SU‐E‐T‐324: A Nephron‐Based Dosimetry Model for Alpha‐Particle Radiopharmaceutical Therapy by Hobbs, R, Song, H, Huso, D, Sgouros, G

“…Purpose: We describe a nephron‐based dosimetry model for renal toxicity for alpha‐particle radipharmaceutical therapy suited to the short range and high linear…”
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Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice by Mohammad, H P, Zhang, W, Prevas, H S, Leadem, B R, Zhang, M, Herman, J G, Hooker, C M, Watkins, D N, Karim, B, Huso, D L, Baylin, S B

“…Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with…”
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Combination Bacteriolytic Therapy for the Treatment of Experimental Tumors by Dang, Long H., Bettegowda, Chetan, Huso, David L., Kinzler, Kenneth W., Vogelstein, Bert

“…Current chemotherapeutic approaches for cancer are in part limited by the inability of drugs to destroy neoplastic cells within poorly vascularized…”
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Targeting Vascular and Avascular Compartments of Tumors with C. novyi-NT and Anti-microtubule Agents by Dang, L.H., Bettegowda, C., Agrawal, N., Cheong, I., Huso, D., Frost, P., Loganzo, F., Greenberger, L., Barkoczy, J., Pettit, G.R., Smith, A.B., Gurulingappa, H., Khan, S., Parmigiani, G., Kinzler, K.W., Zhou, S., Vogelstein, B.

“…Current approaches for treating cancer are limited, in part, by the inability of drugs to affect the poorly vascularized regions of tumors. We have found that…”
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Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm by Doyle, Alexander J, Doyle, Jefferson J, Bessling, Seneca L, Maragh, Samantha, Lindsay, Mark E, Schepers, Dorien, Gillis, Elisabeth, Mortier, Geert, Homfray, Tessa, Sauls, Kimberly, Norris, Russell A, Huso, Nicholas D, Leahy, Dan, Mohr, David W, Caulfield, Mark J, Scott, Alan F, Destrée, Anne, Hennekam, Raoul C, Arn, Pamela H, Curry, Cynthia J, Van Laer, Lut, McCallion, Andrew S, Loeys, Bart L, Dietz, Harry C

“…Harry Dietz and colleagues report the identification of mutations in SKI in Shprintzen-Goldberg syndrome, which shares features with Marfan syndrome and…”
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In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates by Dicello, J F, Christian, A, Cucinotta, F A, Gridley, D S, Kathirithamby, R, Mann, J, Markham, A R, Moyers, M F, Novak, G R, Piantadosi, S, Ricart-Arbona, R, Simonson, D M, Strandberg, J D, Vazquez, M, Williams, J R, Zhang, Y, Zhou, H, Huso, D

“…Standard methods for risk assessments resulting from human exposures to mixed radiation fields in Space consisting of different particle types and energies…”
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Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG by Sun, Lin-Quan, Lee, David W, Zhang, Quangeng, Xiao, Weihong, Raabe, Eric H, Meeker, Alan, Miao, Dengshun, Huso, David L, Arceci, Robert J

“…Imperfect maintenance of genome integrity has been postulated to be an important cause of aging. Here we provide support for this hypothesis by demonstrating…”
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Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock by Yoo, Joo-Yeon, Huso, David L., Nathans, Daniel, Desiderio, Stephen

“…Alternative splicing of the gene for Stat3, a transcription factor activated by the IL-6 family of cytokines, produces two isoforms: Stat3α and a…”
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Nitric Oxide Synthase in Cardiac Sarcoplasmic Reticulum by Xu, Kai Y., Huso, David L., Dawson, Ted M., Bredt, David S., Becker, Lewis C.

“…NO·is a free radical that modulates heart function and metabolism. We report that a neuronal-type NO synthase (NOS) is located on cardiac sarcoplasmic…”
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The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia by YI XU, SUMTER, Takita Felder, BHATTACHARYA, Raka, TESFAYE, Abeba, FUCHS, Ephraim J, WOOD, Lisa J, HUSO, David L, RESAR, Linda M. S

“…HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with…”
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Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease by BALDWIN, B. R, LI, L, TSE, K.-F, SMALL, S, COLLECTOR, M, WHARTENBY, K. A, SHARKIS, S. J, RACKE, F, HUSO, D, SMALL, D

“…Evidence is continuing to accumulate that the FMS-like tyrosine kinase 3 (FLT3) receptor plays an important role in acute leukemias. Acute myeloid leukemia…”
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Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis by LING QI, STRONG, Margaret A, KARIM, Baktiar O, ARMANIOS, Mary, HUSO, David L, GREIDER, Carol W

“…To examine the role of ataxia-telangiectasia mutated (Atm) in telomere function, we generated Atm and telomerase null mice (Atm(-/-) mTR(-/-) iG6 mice). These…”
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