Search Results - "Hushpulian, Dmitry"

Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy by Tapias, Victor, Jainuddin, Shari, Ahuja, Manuj, Stack, Cliona, Elipenahli, Ceyhan, Vignisse, Julie, Gerges, Meri, Starkova, Natalia, Xu, Hui, Starkov, Anatoly A, Bettendorff, Lucien, Hushpulian, Dmitry M, Smirnova, Natalya A, Gazaryan, Irina G, Kaidery, Navneet A, Wakade, Sushama, Calingasan, Noel Y, Thomas, Bobby, Gibson, Gary E, Dumont, Magali, Beal, M Flint

“…Abstract Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as…”
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Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease by Ahuja, Manuj, Ammal Kaidery, Navneet, Yang, Lichuan, Calingasan, Noel, Smirnova, Natalya, Gaisin, Arsen, Gaisina, Irina N, Gazaryan, Irina, Hushpulian, Dmitry M, Kaddour-Djebbar, Ismail, Bollag, Wendy B, Morgan, John C, Ratan, Rajiv R, Starkov, Anatoly A, Beal, M Flint, Thomas, Bobby

“…A promising approach to neurotherapeutics involves activating the nuclear-factor-E2-related factor 2 (Nrf2)/antioxidant response element signaling, which…”
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Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease by Ahuja, Manuj, Kaidery, Navneet Ammal, Attucks, Otis C., McDade, Erin, Hushpulian, Dmitry M., Gaisin, Arsen, Gaisina, Irina, Ahn, Young Hoon, Nikulin, Sergey, Poloznikov, Andrey, Gazaryan, Irina, Yamamoto, Masayuki, Matsumoto, Mitsuyo, Igarashi, Kazuhiko, Sharma, Sudarshana M., Thomas, Bobby

“…Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by the loss of nigrostriatal dopaminergic neurons. Mounting…”
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Emerging small molecule inhibitors of Bach1 as therapeutic agents: Rationale, recent advances, and future perspectives by Hushpulian, Dmitry M., Kaidery, Navneet Ammal, Dutta, Debashis, Sharma, Sudarshana M., Gazaryan, Irina, Thomas, Bobby

“…The transcription factor Nrf2 is the master regulator of cellular stress response, facilitating the expression of cytoprotective genes, including those…”
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Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease by Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A, Hushpulian, Dmitry M, Liby, Karen T, Williams, Charlotte R, Yamamoto, Masayuki, Kensler, Thomas W, Ratan, Rajiv R, Sporn, Michael B, Beal, M Flint, Gazaryan, Irina G, Thomas, Bobby

“…Although the etiology of Parkinson's disease (PD) remains unclear, ample empirical evidence suggests that oxidative stress is a major player in the development…”
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Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue by Hushpulian, Dmitry M, Ammal Kaidery, Navneet, Ahuja, Manuj, Poloznikov, Andrey A, Sharma, Sudarshana M, Gazaryan, Irina G, Thomas, Bobby

“…The Keap1-Nrf2 signaling axis is a validated and promising target for cellular defense and survival pathways. This minireview discusses the potential…”
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A critical appraisal of ferroptosis in Alzheimer's and Parkinson's disease: new insights into emerging mechanisms and therapeutic targets by Soni, Priyanka, Ammal Kaidery, Navneet, Sharma, Sudarshana M, Gazaryan, Irina, Nikulin, Sergey V, Hushpulian, Dmitry M, Thomas, Bobby

“…Neurodegenerative diseases represent a pressing global health challenge, and the identification of novel mechanisms underlying their pathogenesis is of utmost…”
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Structure-Functional Examination of Novel Ribonucleoside Hydrolase C (RihC) from Limosilactobacillus reuteri LR1 by Shaposhnikov, Leonid A, Chikurova, Natalia Yu, Atroshenko, Denis L, Savin, Svyatoslav S, Kleymenov, Sergei Yu, Chernobrovkina, Alla V, Pometun, Evgenii V, Minyaev, Mikhail E, Matyuta, Ilya O, Hushpulian, Dmitry M, Boyko, Konstantin M, Tishkov, Vladimir I, Pometun, Anastasia A

“…Ribonucleoside hydrolase C (RihC, EC 3.2.2.1, 3.2.2.2, 3.2.2.3, 3.2.2.7, 3.2.2.8) belongs to the family of ribonucleoside hydrolases Rih and catalyzes the…”
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Highly sensitive, stable and selective hydrogen peroxide amperometric biosensors based on peroxidases from different sources wired by Os-polymer: A comparative study by Bollella, Paolo, Medici, Luca, Tessema, Merid, Poloznikov, Andrey A., Hushpulian, Dmitry M., Tishkov, Vladimir I., Andreu, Rafael, Leech, Dónal, Megersa, Negussie, Marcaccio, Massimo, Gorton, Lo, Antiochia, Riccarda

“…A comparison was made between two plant peroxidases, cationic horseradish peroxidase (HRP) and anionic tobacco peroxidase (TOP), combined with a highly…”
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Carotenoids from Starfish Patiria pectinifera: Therapeutic Activity in Models of Inflammatory Diseases by Popov, Aleksandr M., Kozlovskaya, Emma P., Klimovich, Anna A., Rutckova, Tatyana A., Vakhrushev, Aleksey I., Hushpulian, Dmitry M., Gazaryan, Irina G., Makhankov, Vyacheslav V., Son, Oksana M., Tekutyeva, Liudmila A.

“…The carotenoids mixture (MC) isolated from the starfish Patiria. pectinifera contains more than 50% astaxanthin, 4–6% each zeaxanthine and lutein, and less…”
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Influence of tryptophan mutation on the direct electron transfer of immobilized tobacco peroxidase by Olloqui-Sariego, José Luis, Zakharova, Galina S., Poloznikov, Andrey A., Calvente, Juan José, Hushpulian, Dmitry M., Gorton, Lo, Andreu, Rafael

“…A major challenge in the design of electrochemical biodevices is to achieve fast rates of electron exchange between proteins and electrodes. In this work, we…”
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HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons by Poloznikov, Andrey A, Nersisyan, Stepan A, Hushpulian, Dmitry M, Kazakov, Eliot H, Tonevitsky, Alexander G, Kazakov, Sergey V, Vechorko, Valery I, Nikulin, Sergey V, Makarova, Julia A, Gazaryan, Irina G

“…The review analyzes the potential advantages and problems associated with using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19. HIF prolyl…”
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The Fe (III)/Fe(II) redox couple as a probe of immobilized tobacco peroxidase: Effect of the immobilization protocol by Olloqui-Sariego, José Luis, Zakharova, Galina S., Poloznikov, Andrey A., Calvente, Juan José, Hushpulian, Dmitry M., Gorton, Lo, Andreu, Rafael

“…Non-turnover voltammetry is a sensitive tool to characterize the electrochemical properties of redox proteins. However, the catalytically competent oxidation…”
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Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2 by Popov, Alexander, Klimovich, Anna, Styshova, Olga, Tsybulsky, Alexander, Hushpulian, Dmitry, Osipyants, Andrey, Khristichenko, Anna, Kazakov, Sergey, Ahuja, Manuj, Kaidery, Navneet, Thomas, Bobby, Tishkov, Vladimir, Brown, Abraham, Gazaryan, Irina, Poloznikov, Andrey

“…Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich's adenocarcinoma. In a solid tumor model…”
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Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3′-diindolylmethane and chemotherapy drugs by Nikulin, Sergey V., Alekseev, Boris Ya, Sergeeva, Nataliya S., Karalkin, Pavel A., Nezhurina, Elizaveta K., Kirsanova, Valentina A., Sviridova, Irina K., Akhmedova, Suraja A., Volchenko, Nadezhda N., Bolotina, Larisa V., Osipyants, Andrey I., Hushpulian, Dmitry M., Topchiy, Maxim A., Asachenko, Andrey F., Koval, Anastasia P., Shcherbo, Dmitry S., Kiselev, Vsevolod I., Mikhaylenko, Dmitry S., Schumacher, Udo, Poloznikov, Andrey A.

“…Epigenetic alterations represent promising therapeutic targets in cancer treatment. Recently it was revealed that small molecules have the potential to act as…”
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Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs by Gaisina, Irina N., Hushpulian, Dmitry M., Gaisin, Arsen M., Kazakov, Eliot H., Ammal Kaidery, Navneet, Ahuja, Manuj, Poloznikov, Andrey A., Gazaryan, Irina G., Thatcher, Gregory R.J., Thomas, Bobby

“…Aspirin is a desired leaving group in prodrugs aimed at treatment of neurodegeneration and other conditions. A library of aspirin derivatives of various…”
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Interprotein Coupling Enhances the Electrocatalytic Efficiency of Tobacco Peroxidase Immobilized at a Graphite Electrode by Olloqui-Sariego, José Luis, Zakharova, Galina S, Poloznikov, Andrey A, Calvente, Juan José, Hushpulian, Dmitry M, Gorton, Lo, Andreu, Rafael

“…Covalent immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-step protocol, in which surface carboxylic groups are…”
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Fenton-like Inactivation of Tobacco Peroxidase Electrocatalysis at Negative Potentials by Olloqui-Sariego, José Luis, Zakharova, Galina S, Poloznikov, Andrey A, Calvente, Juan José, Hushpulian, Dmitry M, Gorton, Lo, Andreu, Rafael

“…The effect of the operational potential on the stability of electrochemical biosensors is particularly relevant in the case of peroxidase biosensors, because…”
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Highly Sensitive Hydrogen Peroxide Biosensor Based on Tobacco Peroxidase Immobilized on p‐Phenylenediamine Diazonium Cation Grafted Carbon Nanotubes: Preventing Fenton‐like Inactivation at Negative Potential by Ciogli, Leonardo, Zumpano, Rosaceleste, Poloznikov, Andrey A., Hushpulian, Dmitry M., Tishkov, Vladimir I., Andreu, Rafael, Gorton, Lo, Mazzei, Franco, Favero, Gabriele, Bollella, Paolo

“…Herein, we present a novel electrode platform for H2O2 detection based on the immobilization of recombinant Tobacco Peroxidase (r‐TOP) onto graphite electrodes…”
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Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model by Savyuk, Maria, Krivonosov, Mikhail, Mishchenko, Tatiana, Gazaryan, Irina, Ivanchenko, Mikhail, Khristichenko, Anna, Poloznikov, Andrey, Hushpulian, Dmitry, Nikulin, Sergey, Tonevitsky, Evgeny, Abuzarova, Guzal, Mitroshina, Elena, Vedunova, Maria

“…A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in…”
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