Effect of Riluzole on Spinal Cord Regeneration with Hemisection Method Before Injury

Effect of Riluzole on Spinal Cord Regeneration with Hemisection Method Before Injury

The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have...

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Bibliographic Details
Published in:World neurosurgery Vol. 114; pp. e247 - e253
Main Authors: Caglar, Yusuf Sukru, Demirel, Altan, Dogan, Ihsan, Huseynov, Ramis, Eroglu, Umit, Ozgural, Onur, Cansiz, Cevriye, Bahadir, Burak, Kilinc, Mustafa Cemil, Al-Beyati, Eyyub S.M.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-06-2018
Subjects:
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Laminectomy - adverse effects
Locomotion - drug effects
Male
Myelin Sheath - drug effects
Myelin Sheath - physiology
Nerve Regeneration - drug effects
Neuroprotection
Neuroprotective Agents - therapeutic use
Neuroregeneration
Rats
Rats, Wistar
Recovery of Function
Riluzole
Riluzole - therapeutic use
Severity of Illness Index
Spinal Cord Injuries - prevention & control
Spinal cord injury
NACT
Neuroprotection
BBB
SCI
Spinal cord injury
Riluzole
HE
Neuroregeneration
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Summary:The pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown in experimental studies. This study aimed to investigate the effect of riluzole on neural regeneration in a rat SCI model. Thirty-two rats were divided into 8 groups, with 4 rats in each group. Hemisection method was performed after T7–T9 laminectomy. Rats were intraperitoneally aministered with riluzole (6 mg/kg). Locomotor recovery of the rats was assessed at 1 day, and 1, 2, 3, and 4 weeks after the 21-point Basso, Beattie, and Bresnahan test. Subsequently, the spinal cords of the rats were scored according to a semiquantitative grading system using a light microscope, and the numbers of myelinated axons, neurons, and glial cells were calculated. Basso, Beattie, and Bresnahan test changes were statistically significant when groups 4–6 and 8 were compared with the other groups (P < 0.05, P < 0.00625). The results of the numbers of neurons, glial cells, and myelinated axons were statistically significant. Especially group 8, in which riluzole was administered 5 days before injury, more positive clinical and histopathologic results were obtained. Riluzole treatment is more effective when provided before injury. Riluzole may contribute to functional recovery when used in the preoperative period in patients who are at a high risk for permanent neurologic deficit. •Riluzole treatment is more effective before injury.•Positive clinical results were obtained in groups given riluzole before injury.•Recurrent riluzole application increases neuroregeneration.
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ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2018.02.171