Search Results - "Huseby, Eric S"

Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance by Stepanek, Ondrej, Prabhakar, Arvind S., Osswald, Celine, King, Carolyn G., Bulek, Anna, Naeher, Dieter, Beaufils-Hugot, Marina, Abanto, Michael L., Galati, Virginie, Hausmann, Barbara, Lang, Rosemarie, Cole, David K., Huseby, Eric S., Sewell, Andrew K., Chakraborty, Arup K., Palmer, Ed

“…In the thymus, high-affinity, self-reactive thymocytes are eliminated from the pool of developing T cells, generating central tolerance. Here, we investigate…”
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A temporal thymic selection switch and ligand binding kinetics constrain neonatal Foxp3+ Treg cell development by Stadinski, Brian D., Blevins, Sydney J., Spidale, Nicholas A., Duke, Brian R., Huseby, Priya G., Stern, Lawrence J., Huseby, Eric S.

“…The neonatal thymus generates Foxp3 + regulatory T (tT reg ) cells that are critical in controlling immune homeostasis and preventing multiorgan autoimmunity…”
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Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation by Keck, Simone, Schmaler, Mathias, Ganter, Stefan, Wyss, Lena, Oberle, Susanne, Huseby, Eric S., Zehn, Dietmar, King, Carolyn G.

“…Significance T-cell receptor recognition of antigen is an essential first step in the initiation of a T-cell response. This report demonstrates that CD4 T…”
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A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands by Stadinski, Brian D., Trenh, Peter, Smith, Rebecca L., Bautista, Bianca, Huseby, Priya G., Li, Guoqi, Stern, Lawrence J., Huseby, Eric S.

“…A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex…”
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Fast on-rates allow short dwell time ligands to activate T cells by Govern, Christopher C, Paczosa, Michelle K, Chakraborty, Arup K, Huseby, Eric S

“…Two contrasting theories have emerged that attempt to describe T-cell ligand potency, one based on the t₁/₂ of the interaction and the other based on the…”
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How the thymus designs antigen-specific and self-tolerant T cell receptor sequences by Košmrlj, Andrej, Jha, Abhishek K, Huseby, Eric S, Kardar, Mehran, Chakraborty, Arup K

“…T lymphocytes (T cells) orchestrate adaptive immune responses that clear pathogens from infected hosts. T cells recognize short peptides (p) derived from…”
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Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection by Vanguri, Vijay, Govern, Christopher C., Smith, Rebecca, Huseby, Eric S.

“…T-cell recognition of ligands is polyspecific. This translates into antiviral T-cell responses having a range of potency and specificity for viral ligands. How…”
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Ligand mobility modulates immunological synapse formation and T cell activation by Hsu, Chih-Jung, Hsieh, Wan-Ting, Waldman, Abraham, Clarke, Fiona, Huseby, Eric S, Burkhardt, Janis K, Baumgart, Tobias

“…T cell receptor (TCR) engagement induces clustering and recruitment to the plasma membrane of many signaling molecules, including the protein tyrosine kinase…”
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The partitioning of TCR repertoires by thymic selection by Lo, Wan-Lin, Huseby, Eric S

“…αβ T cells are critical components of the adaptive immune system; they maintain tissue and immune homeostasis during health, provide sterilizing immunity after…”
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Effect of CDR3 sequences and distal V gene residues in regulating TCR-MHC contacts and ligand specificity by Stadinski, Brian D, Trenh, Peter, Duke, Brian, Huseby, Priya G, Li, Guoqi, Stern, Lawrence J, Huseby, Eric S

“…The mature T cell repertoire has the ability to orchestrate immunity to a wide range of potential pathogen challenges. This ability stems from thymic…”
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Role of T cell-glial cell interactions in creating and amplifying central nervous system inflammation and multiple sclerosis disease symptoms by Huseby, Eric S, Kamimura, Daisuke, Arima, Yasunobu, Parello, Caitlin S, Sasaki, Katsuhiro, Murakami, Masaaki

“…Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System (CNS) that causes the demyelination of nerve cells and destroys…”
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The perception and response of T cells to a changing environment are based on the law of initial value by Huseby, Eric S, Teixeiro, Emma

“…αβ T cells are critical components of the adaptive immune system and are capable of inducing sterilizing immunity after pathogen infection and eliminating…”
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Response to Garcia et al by Huseby, Eric S, Stadinski, Brian D, Trenh, Peter, Stern, Lawrence J

“…[...]our experiments showed that TCRβ and IAbα side chains were differentially required by the MHC-specific TCRs for binding depending on the TCRα chain…”
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The curious case of a cryptic Cryptosporidium and a missing dendritic cell subset by Lee, Donguk, Huseby, Eric S., Gowthaman, Uthaman

“…Animal models for studying immune responses to Cryptosporidium, a parasite that causes gastrointestinal disease, have been a challenge due to the parasite's…”
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How persistent infection overcomes peripheral tolerance mechanisms to cause T cell-mediated autoimmune disease by Yin, Rose, Melton, Samuel, Huseby, Eric S, Kardar, Mehran, Chakraborty, Arup K

“…T cells help orchestrate immune responses to pathogens, and their aberrant regulation can trigger autoimmunity. Recent studies highlight that a threshold…”
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Hydrophobic CDR3 residues promote the development of self-reactive T cells by Stadinski, Brian D, Shekhar, Karthik, Gómez-Touriño, Iria, Jung, Jonathan, Sasaki, Katsuhiro, Sewell, Andrew K, Peakman, Mark, Chakraborty, Arup K, Huseby, Eric S

“…Through analyses of β-chain variable regions in self-reactive T cell antigen receptors, Huseby and colleagues show that an index based on the interfacial…”
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Resolving the Instructions for αβ T Cell Development by Cleveland, Sarah B, Huseby, Eric S

“…In this issue of Immunity, Chopp et. al. use single-cell transcriptomics and epigenomics in mice and human samples to delineate developmental trajectories of…”
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Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection by Tubo, Noah J., Pagán, Antonio J., Taylor, Justin J., Nelson, Ryan W., Linehan, Jonathan L., Ertelt, James M., Huseby, Eric S., Way, Sing Sing, Jenkins, Marc K.

“…A naive CD4+ T cell population specific for a microbial peptide:major histocompatibility complex II ligand (p:MHCII) typically consists of about 100 cells,…”
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Negative Selection Imparts Peptide Specificity to the Mature T Cell Repertoire by Huseby, Eric S., Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa

“…The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the…”
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Killer T cells with a beta-flavi(r) for dengue by Blevins, Sydney, Huseby, Eric S

“…Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact…”
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