Search Results - "Huse, J."

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas by Yan, D, Kowal, J, Akkari, L, Schuhmacher, A J, Huse, J T, West, B L, Joyce, J A

“…Glioblastomas represent the most aggressive glioma grade and are associated with a poor patient prognosis. The current standard of care, consisting of surgery,…”
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Diagnostic Accuracy of T1-Weighted Dynamic Contrast-Enhanced-MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma by Lin, X, Lee, M, Buck, O, Woo, K M, Zhang, Z, Hatzoglou, V, Omuro, A, Arevalo-Perez, J, Thomas, A A, Huse, J, Peck, K, Holodny, A I, Young, R J

“…Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging…”
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Suppressed immune microenvironment and repertoire in brain metastases from patients with resected non-small-cell lung cancer by Kudo, Y., Haymaker, C., Zhang, J., Reuben, A., Duose, D.Y., Fujimoto, J., Roy-Chowdhuri, S., Solis Soto, L.M., Dejima, H., Parra, E.R., Mino, B., Abraham, R., Ikeda, N., Vaporcyan, A., Gibbons, D., Zhang, J., Lang, F.F., Luthra, R., Lee, J.J., Moran, C., Huse, J.T., Kadara, H., Wistuba, I.I.

“…The tumor immune microenvironment (TIME) of lung cancer brain metastasis is largely unexplored. We carried out immune profiling and sequencing analysis of…”
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Cellular Density in Adult Glioma, Estimated with MR Imaging Data and a Machine Learning Algorithm, Has Prognostic Power Approaching World Health Organization Histologic Grading in a Cohort of 1181 Patients by Gates, E D H, Suki, D, Celaya, A, Weinberg, J S, Prabhu, S S, Sawaya, R, Huse, J T, Long, J P, Fuentes, D, Schellingerhout, D

“…Recent advances in machine learning have enabled image-based prediction of local tissue pathology in gliomas, but the clinical usefulness of these predictions…”
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Potential role of preoperative conventional MRI including diffusion measurements in assessing epidermal growth factor receptor gene amplification status in patients with glioblastoma by Young, R J, Gupta, A, Shah, A D, Graber, J J, Schweitzer, A D, Prager, A, Shi, W, Zhang, Z, Huse, J, Omuro, A M P

“…Epidermal growth factor receptor amplification is a common molecular event in glioblastomas. The purpose of this study was to examine the potential usefulness…”
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Pretreatment Dynamic Susceptibility Contrast MRI Perfusion in Glioblastoma: Prediction of EGFR Gene Amplification by Gupta, A., Young, R. J., Shah, A. D., Schweitzer, A. D., Graber, J. J., Shi, W., Zhang, Z., Huse, J., Omuro, A. M. P.

“…Background and Purpose Molecular and genetic testing is becoming increasingly relevant in GBM. We sought to determine whether dynamic susceptibility contrast…”
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Transcriptional diversity of long-term glioblastoma survivors by Gerber, Naamit K, Goenka, Anuj, Turcan, Sevin, Reyngold, Marsha, Makarov, Vladimir, Kannan, Kasthuri, Beal, Kathryn, Omuro, Antonio, Yamada, Yoshiya, Gutin, Phillip, Brennan, Cameron W, Huse, Jason T, Chan, Timothy A

“…Glioblastoma (GBM) is a highly aggressive type of glioma with poor prognosis. However, a small number of patients live much longer than the median survival. A…”
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Hemangioma of the cavernous sinus in a child by LITKOWSKI, P, KHAKOO, Y, GILHEENEY, S, SOUWEIDANE, M, HUSE, J, HAQUE, S, YOUNG, R. J

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Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase by Huse, J T, Pijak, D S, Leslie, G J, Lee, V M, Doms, R W

“…The amyloidogenic Abeta peptide is liberated from the amyloid precursor protein (APP) by two proteolytic activities, beta-secretase and gamma-secretase…”
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β-Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer’s Disease Brain by Huse, Jason T., Liu, Kangning, Pijak, Donald S., Carlin, Dan, Lee, Virginia M.-Y., Doms, Robert W.

“…The amyloid β (Aβ) peptide that accumulates in Alzheimer’s disease brain is derived from the proteolytic processing of the amyloid precursor protein by β- and…”
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Neurotoxic Traffic: Uncovering the Mechanics of Amyloid Production in Alzheimer's Disease by Huse, Jason T., Doms, Robert W.

“…Alzheimer's disease (AD) is thought by many to result from the accumulation of the neurotoxic amyloid‐β (Aβ) peptide in brain parenchyma. The process by which…”
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Transcriptomic changes following chronic administration of selective serotonin reuptake inhibitors: a review of animal studies by Kumar, Sahel, Gal, Zsofia, Gonda, Xenia, Huse, Robin J, Juhasz, Gabriella, Bagdy, Gyorgy, Petschner, Peter

“…The review focuses on transcriptomic changes following treatment with serotonin reuptake inhibitor (SSRI) antidepressants. We aimed to overview results of the…”
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Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease by Huse, J T, Doms, R W

“…Accumulation of the amyloid-beta (A beta) peptide in the central nervous system (CNS) is considered by many to be the crucial pathological insult that…”
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ATRX Mutant Glioblastoma Stem Cell (GSC) Lines with the Alternative Lengthening of Telomeres Phenotype Display Sensitivity to G-Quadruplex Stabilization by Farooqi, A., Dharmiah, S., Alvarez, C., Yang, J., Sharin, V., Danussi, C., Irwin, D., Ezhilarasan, R., Sulman, E.P., Huse, J.

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Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation by Huse, Jason T, Byant, Damani, Yang, Yaxiong, Pijak, Donald S, D'Souza, Ian, Lah, James J, Lee, Virginia M-Y, Doms, Robert W, Cook, David G

“…Sequential proteolysis of the amyloid precursor protein (APP) by beta- and gamma-secretase activities yields the amyloid beta peptide that is widely deposited…”
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OC-0165 Patterns of treatment and outcomes for 1p19q co-deleted gliomas by Yeboa, D., Yu, J., Liao, K.E., Huse, J., Penas-Prado, M., Kann, B., Sulman, E., Grosshans, D., Contessa, J.

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KS02.7.A LONGITUDINAL SINGLE-CELL ANALYSES IDENTIFY DRIVERS OF GENETIC, EPIGENOMIC, AND CELLULAR EVOLUTION IN IDH-MUTANT GLIOMA by Johnson, K C, Spitzer, A, Varn, F S, Nomura, M, Garofano, L, Chowdhury, T, Anderson, K J, D’Angelo, F, Bussema, L, Gritsch, S, Oh, Y, Moon, H, Paek, S, Bielle, F, Laurenge, A, Di Stefano, A, Mathon, B, Picca, A, Sanson, M, Lipsa, A, Hertel, F, Zhao, Z, Wang, Q, Jiang, T, Hermes, B, Sanai, N, Golebiewska, A, Niclou, S P, Huse, J, Yung, W, Lasorella, A, Suvà, M L, Iavarone, A, Tirosh, I, Verhaak, R G

“…Abstract BACKGROUND Hotspot mutations in the IDH genes serve as tumor-initiating events that define a subset of adult diffuse glioma that can further be…”
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Personalizing Parkinson's disease through the journey of Michael J. Fox by Huse, Jaclynn

“…Not only does this 7-minute video clip allow students to visualize how Parkinson's disease physically affects Fox, but it also stimulates the process of…”
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ELUCIDATING THE ONCOGENIC ROLE OF ATRX DEFICIENCY IN GLIOMA by Huse, J. T.

“…We and others recently identified loss-of-function mutations in the ATRX gene as core components of a highly recurrent molecular signature characterizing adult…”
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CMV and glioma--are we there yet? by Huse, Jason T, Aldape, Kenneth

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