A case of cryptococcal pneumonia accompanying meningitis

Cryptococcosis is a fungal infection caused by cryptococcus neoformans. Cryptococcal pneumonia occurs due to inhalation of the organism into the respiratory tract, sometimes accompanied by meningitis in immunocompromised patients, and can be life-threatening. We report a case of cryptococcal meningi...

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Bibliographic Details
Published in:	Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society Vol. 47; no. 1; p. 12
Main Authors:	Tajiri, Tomoko, Ikeue, Tatsuyoshi, Nakagawa, Atsushi, Huruta, Kenjiro, Morita, Kyohei, Maniwa, Ko, Watanabe, Shigeki, Sugita, Takakazu, Horikawa, Sadao, Nishiyama, Hideki, Maekawa, Nobuo
Format:	Journal Article
Language:	Japanese
Published:	Japan 01-01-2009
Subjects:	Adrenal Cortex Hormones - adverse effects Aged, 80 and over Arthritis, Rheumatoid - drug therapy Cryptococcosis - etiology Female Humans Immunocompromised Host Meningitis, Cryptococcal - etiology Pneumonia - complications
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Summary:	Cryptococcosis is a fungal infection caused by cryptococcus neoformans. Cryptococcal pneumonia occurs due to inhalation of the organism into the respiratory tract, sometimes accompanied by meningitis in immunocompromised patients, and can be life-threatening. We report a case of cryptococcal meningitis occurring during corticosteroid therapy for rheumatoid arthritis. A 82-year-old woman with rheumatoid arthritis was given a diagnosis of cryptococcal meningitis, and improved after administeration of amphotericin B in combination with flucytosine. However 3 weeks later, side effects occurred, she was given fluconazole alone, but her condition worsened and she died. In severe cases of cryptococcal meningitis, we should take into account drug susceptibility tests and drug concentrations at the site of infection.
ISSN:	1343-3490