Search Results - "Hursting, Stephen D"

Obesity and cancer: mechanistic insights from transdisciplinary studies by Allott, Emma H, Hursting, Stephen D

“…Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer. Herein, we summarize epidemiologic…”
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Energy Balance, Host-Related Factors, and Cancer Progression by Hursting, Stephen D, Berger, Nathan A

“…Obesity is associated with an increased risk and worsened prognosis for many types of cancer, but the mechanisms underlying the obesity-cancer progression link…”
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Energy balance and obesity: what are the main drivers? by Romieu, Isabelle, Dossus, Laure, Barquera, Simón, Blottière, Hervé M., Franks, Paul W., Gunter, Marc, Hwalla, Nahla, Hursting, Stephen D., Leitzmann, Michael, Margetts, Barrie, Nishida, Chizuru, Potischman, Nancy, Seidell, Jacob, Stepien, Magdalena, Wang, Youfa, Westerterp, Klaas, Winichagoon, Pattanee, Wiseman, Martin, Willett, Walter C.

“…Purpose The aim of this paper is to review the evidence of the association between energy balance and obesity. Methods In December 2015, the International…”
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When less may be more: calorie restriction and response to cancer therapy by O'Flanagan, Ciara H, Smith, Laura A, McDonell, Shannon B, Hursting, Stephen D

“…Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and…”
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Obesity, metabolic dysregulation, and cancer: a growing concern and an inflammatory (and microenvironmental) issue by Hursting, Stephen D., Dunlap, Sarah M.

“…Obesity is an established risk and progression factor for many cancers. In the United States more than one‐third of adults, and nearly one in five children,…”
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The growing challenge of obesity and cancer: an inflammatory issue by Harvey, Alison E., Lashinger, Laura M., Hursting, Stephen D.

“…The prevalence of obesity, an established risk factor for many cancers, has risen steadily for the past several decades in the United States and in many parts…”
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Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells by Lyons, Amy, Coleman, Michael, Riis, Sarah, Favre, Cedric, O'Flanagan, Ciara H., Zhdanov, Alexander V., Papkovsky, Dmitri B., Hursting, Stephen D., O'Connor, Rosemary

“…Mitochondrial activity and metabolic reprogramming influence the phenotype of cancer cells and resistance to targeted therapy. We previously established that…”
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Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression by Olivo-Marston, Susan E, Hursting, Stephen D, Perkins, Susan N, Schetter, Aaron, Khan, Mohammed, Croce, Carlo, Harris, Curtis C, Lavigne, Jackie

“…Obesity is an established colon cancer risk factor, while preventing or reversing obesity via a calorie restriction (CR) diet regimen decreases colon cancer…”
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Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms by Cifarelli, Vincenza, Lashinger, Laura M, Devlin, Kaylyn L, Dunlap, Sarah M, Huang, Jennifer, Kaaks, Rudolf, Pollak, Michael N, Hursting, Stephen D

“…Metformin treatment is associated with a decreased risk and better prognosis of pancreatic cancer (PC) in patients with type 2 diabetes, but the mechanism of…”
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You complete me: tumor cell-myeloid cell nuclear fusion as a facilitator of organ-specific metastasis by Cozzo, Alyssa J, Coleman, Michael F, Hursting, Stephen D

“…Every cancer genome is unique, resulting in potentially near infinite cancer cell phenotypes and an inability to predict clinical outcomes in most cases…”
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Leptin Signaling Mediates Obesity-Associated CSC Enrichment and EMT in Preclinical TNBC Models by Bowers, Laura W, Rossi, Emily L, McDonell, Shannon B, Doerstling, Steven S, Khatib, Subreen A, Lineberger, Claire G, Albright, Jody E, Tang, Xiaohu, deGraffenried, Linda A, Hursting, Stephen D

“…Obesity is associated with poor prognosis in triple-negative breast cancer (TNBC). Preclinical models of TNBC were used to test the hypothesis that increased…”
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Obesity, energy balance, and cancer: new opportunities for prevention by Hursting, Stephen D, Digiovanni, John, Dannenberg, Andrew J, Azrad, Maria, Leroith, Derek, Demark-Wahnefried, Wendy, Kakarala, Madhuri, Brodie, Angela, Berger, Nathan A

“…Obesity is associated with increased risk and poor prognosis for many types of cancer. The mechanisms underlying the obesity-cancer link are becoming…”
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Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors by Doerstling, Steven S, O'Flanagan, Ciara H, Hursting, Stephen D

“…Obesity is associated with increased risk and poor prognosis of many types of cancers. Several obesity-related host factors involved in systemic metabolism can…”
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Hypoxia-mediated repression of pyruvate carboxylase drives immunosuppression by Coleman, Michael F, Cotul, Eylem Kulkoyluoglu, Pfeil, Alexander J, Devericks, Emily N, Safdar, Muhammad H, Monteiro, Marvis, Chen, Hao, Ho, Alyssa N, Attaar, Numair, Malian, Hannah M, Kiesel, Violet A, Ramos, Alexis, Smith, Matthew, Panchal, Heena, Mailloux, Adam, Teegarden, Dorothy, Hursting, Stephen D, Wendt, Michael K

“…Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and…”
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The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link by Bowers, Laura W, Rossi, Emily L, O'Flanagan, Ciara H, deGraffenried, Linda A, Hursting, Stephen D

“…Numerous epidemiological and pre-clinical studies have demonstrated that the insulin/insulin-like growth factor (IGF) system plays a key role in the…”
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Pyruvate carboxylase and cancer progression by Kiesel, Violet A, Sheeley, Madeline P, Coleman, Michael F, Cotul, Eylem Kulkoyluoglu, Donkin, Shawn S, Hursting, Stephen D, Wendt, Michael K, Teegarden, Dorothy

“…Pyruvate carboxylase (PC) is a mitochondrial enzyme that catalyzes the ATP-dependent carboxylation of pyruvate to oxaloacetate (OAA), serving to replenish the…”
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NSAID Use Reduces Breast Cancer Recurrence in Overweight and Obese Women: Role of Prostaglandin-Aromatase Interactions by BOWERS, Laura W, MAXIMO, Ilane X. F, BRENNER, Andrew J, BEERAM, Muralidhar, HURSTING, Stephen D, PRICE, Ramona S, TEKMAL, Rajeshwar R, JOLLY, Christopher A, DEGRAFFENRIED, Linda A

“…Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and…”
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Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner by Harvey, Alison E, Lashinger, Laura M, Hays, Drew, Harrison, Lauren M, Lewis, Kimberly, Fischer, Susan M, Hursting, Stephen D

“…Calorie restriction (CR) prevents obesity and has potent anticancer effects that may be mediated through its ability to reduce serum growth and inflammatory…”
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Metabolic Reprogramming by Folate Restriction Leads to a Less Aggressive Cancer Phenotype by Ashkavand, Zahra, O'Flanagan, Ciara, Hennig, Mirko, Du, Xiuxia, Hursting, Stephen D, Krupenko, Sergey A

“…Folate coenzymes are involved in biochemical reactions of one-carbon transfer, and deficiency of this vitamin impairs cellular proliferation, migration, and…”
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Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells by Zheng, Qiao, Banaszak, Lauren, Fracci, Sarah, Basali, Diana, Dunlap, Sarah M, Hursting, Stephen D, Rich, Jeremy N, Hjlemeland, Anita B, Vasanji, Amit, Berger, Nathan A, Lathia, Justin D, Reizes, Ofer

“…Despite new therapies, breast cancer continues to be the second leading cause of cancer mortality in women, a consequence of recurrence and metastasis. In…”
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