Search Results - "Hurst, R. S"

Pre‐clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence by Rollema, H, Shrikhande, A, Ward, KM, Tingley III, FD, Coe, JW, O'Neill, BT, Tseng, E, Wang, EQ, Mather, RJ, Hurst, RS, Williams, KE, de Vries, M, Cremers, T, Bertrand, S, Bertrand, D

“…Background and purpose:  Smoking cessation trials with three high‐affinity partial agonists of α4β2 neuronal nicotinic acetylcholine receptors (nAChRs) have…”
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Facilitated Glutamatergic Transmission in the Striatum of D2 Dopamine Receptor-Deficient Mice by Cepeda, C, Hurst, R. S, Altemus, K. L, Flores-Hernandez, J, Calvert, C. R, Jokel, E. S, Grandy, D. K, Low, M. J, Rubinstein, M, Ariano, M. A, Levine, M. S

“…  1 Mental Retardation Research Center, University of California, Los Angeles, California 90095;   2 Department of Cell and Developmental Biology and   3…”
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Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium by Kavanaugh, M P, Hurst, R S, Yakel, J, Varnum, M D, Adelman, J P, North, R A

“…RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes…”
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Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels by Hurst, R S, Busch, A E, Kavanaugh, M P, Osborne, P B, North, R A, Adelman, J P

“…alpha-Dendrotoxin (DTX) is a 60-amino acid peptide belonging to the family of mamba snake neurotoxins; it is a potent blocker of some but not all voltage-gated…”
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External barium block of Shaker potassium channels: evidence for two binding sites by Hurst, R S, Latorre, R, Toro, L, Stefani, E

“…External barium ions inhibit K+ currents of Xenopus oocytes expressing ShH4 delta 6-46, the non-inactivating deletion of the Shaker K+ channel. At the…”
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Discovery and Structure-Activity Relationship of Quinuclidine Benzamides as Agonists of alpha 7 Nicotinic Acetylcholine Receptors by Bodnar, AL, Cortes-Burgos, LA, Cook, K K, Dinh, D M, Groppi, V E, Hajos, M, Higdon, N R, Hoffmann, W E, Hurst, R S, Myers, J K, Rogers, B N, Wall, T M, Wolfe, M L, Wong, E

“…A library of benzamides was tested for alpha 7 nicotinic acetylcholine receptor (nAChR) agonist activity using a chimeric receptor in a functional, cell-based,…”
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Transient and Progressive Electrophysiological Alterations in the Corticostriatal Pathway in a Mouse Model of Huntington's Disease by Cepeda, Carlos, Hurst, Raymond S, Calvert, Christopher R, Hernandez-Echeagaray, Elizabeth, Nguyen, Oanh K, Jocoy, Emily, Christian, Lindsey J, Ariano, Marjorie A, Levine, Michael S

“…Alterations in the corticostriatal pathway may precede symptomatology and striatal cell death in Huntington's disease (HD) patients. Here we examined…”
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Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs by HURST, R. S, KAVANAUGH, M. P, YAKEL, J, ADELMAN, J. P, ALAN NORTH, R

“…Four copies of the coding sequence for a voltage-dependent potassium channel (RBK1, rat Kv1.1) were ligated contiguously and transcribed in vitro. The…”
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Current inactivation involves a histidine residue in the pore of the rat lymphocyte potassium channel RGK5 by Busch, A E, Hurst, R S, North, R A, Adelman, J P, Kavanaugh, M P

“…RGK5 is a rat genomic DNA clone that encodes the n-type potassium channel found in T-lymphocytes and other cells. Current through this channel declines…”
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Enhanced Sensitivity to N-Methyl-D-Aspartate Receptor Activation in Transgenic and Knockin Mouse Models of Huntington's Disease by Levine, MS, Klapstein, G J, Koppel, A, Gruen, E, Cepeda, C, Vargas, ME, Jokel, E S, Carpenter, E M, Zanjani, H, Hurst, R S, Efstratiadis, A, Zeitlin, S, Chesselet, M-F

“…We used two mouse models of Huntington's disease (HD) to examine changes in glutamate receptor sensitivity and striatal electrophysiology. One model, a…”
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Facilitated Glutamatergic Transmission in the Striatum of D 2 Dopamine Receptor-Deficient Mice by Cepeda, C., Hurst, R. S., Altemus, K. L., Flores-Hernández, J., Calvert, C. R., Jokel, E. S., Grandy, D. K., Low, M. J., Rubinstein, M., Ariano, M. A., Levine, M. S.

“…Dopamine (DA) receptors play an important role in the modulation of excitability and the responsiveness of neurons to activation of excitatory amino acid…”
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Ionic currents underlying HTRP3 mediated agonist‐dependent Ca2+ influx in stably transfected HEK293 cells by Hurst, Raymond S, Zhu, Xi, Boulay, Guylain, Birnbaumer, Lutz, Stefani, Enrico

“…hTrp3 is a human homologue of the Drosophila gene responsible for a transient receptor potential (trp) mutation. When stably expressed in HEK293 cells, hTrp3…”
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Neurons Recorded from Pediatric Epilepsy Surgery Patients with Cortical Dysplasia by Mathern, Gary W., Cepeda, Carlos, Hurst, Raymond S., Flores‐Hernandez, Jorge, Mendoza, Delia, Levine, Michael S.

“…Purpose: Cortical dysplasia (CD) is a common pathological substrate in patients with early‐onset childhood epilepsy. In CD tissue, little is known about the…”
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Potassium channel assembly from concatenated subunits: effects of proline substitutions in S4 segments by Hurst, R S, North, R A, Adelman, J P

“…A concatenated cDNA was made that comprised four contiguous copies of the rat brain potassium channel subunit Kv1.1. Currents were measured in oocytes that had…”
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Differential sensitivity of medium- and large-sized striatal neurons to NMDA but not kainate receptor activation in the rat by Cepeda, Carlos, Itri, Jason N., Flores-Hernández, Jorge, Hurst, Raymond S., Calvert, Christopher R., Levine, Michael S.

“…Infrared videomicroscopy and differential interference contrast optics were used to identify medium‐ and large‐sized neurons in striatal slices from young…”
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Ionic requirements for establishment of an embryonic axis in Pelvetia zygotes by Hurst, S.R. (University of Utah, Salt Lake City, UT), Kropf, D.L

“…Previous reports have shown that fertilized Pelvetia fastigiata (J. Ag.) DeToni eggs generate a transcellular ionic current which correlates temporally and…”
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Pharmacological profile of the α4β2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid by Rollema, H., Chambers, L.K., Coe, J.W., Glowa, J., Hurst, R.S., Lebel, L.A., Lu, Y., Mansbach, R.S., Mather, R.J., Rovetti, C.C., Sands, S.B., Schaeffer, E., Schulz, D.W., Tingley, F.D., Williams, K.E.

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Molecular determinants of external barium block in Shaker potassium channels by Hurst, Raymond S., Toro, Ligia, Stefani, Enrico

“…Mutations in the outer pore region of Shaker K + channels ( T449 and D 447) can influence external Ba 2+ block. Substitution of T 449 by A, V or Y…”
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Delayed postnatal development of NMDA receptor function in medium-sized neurons of the rat striatum by Hurst, R S, Cepeda, C, Shumate, L W, Levine, M S

“…During early postnatal development, the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor plays a dominant role in excitatory amino acid-mediated…”
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Binding properties of newly identified Xenopus proteins containing dsRNA-binding motifs by Bass, B L, Hurst, S R, Singer, J D

“…Although most RNA-binding proteins recognize a complex set of structural motifs in their RNA target, the double-stranded (ds) RNA-binding proteins are limited…”
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