Search Results - "Hurst, HC"

Expression of the ERBB3 gene product in breast cancer by LEMOINE, N. R, BARNES, D. M, HOLLYWOOD, D. P, HUGHES, C. M, SMITH, P, DUBLIN, E, PRIGENT, S. A, GULLICK, W. J, HURST, H. C

“…Abnormalities of the EGF receptor and/or the related ERBB2 receptor occur in a significant proportion of cases of human breast cancer and are important…”
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Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes by Belandia, Borja, Orford, Rob L., Hurst, Helen C., Parker, Malcolm G.

“…SWI/SNF complexes are ATP‐dependent chromatin remodelling enzymes that have been implicated in the regulation of gene expression in yeast and higher…”
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Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator by Bamforth, Simon D, Marques, Fatima I.R, Kranc, Kamil R, Hurst, Helen C, Farza, Hend, Bragança, José, Eloranta, Jyrki J, Bhattacharya, Shoumo, Murdoch, Jennifer N, Henderson, Deborah J

“…The protein EP300 and its paralog CREBBP (CREB-binding protein) are ubiquitously expressed transcriptional co-activators and histone acetyl transferases. The…”
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Transcriptional regulation of cyclin-dependent kinase inhibitor 1A by the transcription factor AP-2[gamma] by Scibetta, AG, Canosa, M, Hurst, HC

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Transcriptional regulation of cyclin-dependent kinase inhibitor 1A (P21) by the transcription factor AP-2γ by Scibetta, AG, Canosa, M, Hurst, HC

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Physical and Functional Interactions among AP-2 Transcription Factors, p300/CREB-binding Protein, and CITED2 by Bragança, José, Eloranta, Jyrki J., Bamforth, Simon D., Ibbitt, J. Claire, Hurst, Helen C., Bhattacharya, Shoumo

“…The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2)…”
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Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival by Gee, JMW, Eloranta, JJ, Ibbitt, JC, Robertson, JFR, Ellis, IO, Williams, T, Nicholson, RI, Hurst, HC

“…The AP-2γ transcription factor encoded by the TFAP2C gene is a member of a family of homologous DNA binding proteins that play essential roles during…”
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Transcription Factor AP-2 Interacts with the SUMO-conjugating Enzyme UBC9 and Is Sumolated in Vivo by Eloranta, Jyrki J, Hurst, Helen C

“…The members of the AP-2 family of transcription factors are developmentally regulated and have distinct yet overlapping functions in the regulation of many…”
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Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types by Srinivasan, Radhika, Poulsom, Richard, Hurst, Helen C., Gullick, William J.

“…The c‐erbB‐4/HER4 receptor belongs to the family of the type I growth factor receptors. Mouse monoclonal antibodies have been raised to the cytoplasmic domain…”
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Competition on nitrocellulose-immobilized antibody arrays: from bacterial protein binding assay to protein profiling in breast cancer cells by Yeretssian, Garabet, Lecocq, Michèle, Lebon, Guillaume, Hurst, Helen C, Sakanyan, Vehary

“…Large scale comparative evaluation of protein expression requires miniaturized techniques to provide sensitive and accurate measurements of the abundance of…”
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Human CREB-binding Protein/p300-interacting Transactivator with ED-rich Tail (CITED) 4, a New Member of the CITED Family, Functions as a Co-activator for Transcription Factor AP-2 by Bragança, José, Swingler, Tracey, Marques, Fatima I.R., Jones, Tania, Eloranta, Jyrki J., Hurst, Helen C., Shioda, Toshihiro, Bhattacharya, Shoumo

“…Members of the CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) family bind CREB-binding protein and p300 with high affinity and…”
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A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma by Bosher, J M, Totty, N F, Hsuan, J J, Williams, T, Hurst, H C

“…The proto-oncogene c-erbB-2 is overexpressed in 25-30% of breast cancers through increased transcription and amplification of the gene. We have previously…”
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RB and c-Myc Activate Expression of the E-Cadherin Gene in Epithelial Cells through Interaction with Transcription Factor AP-2 by Batsché, Eric, Muchardt, Christian, Behrens, Jürgen, Hurst, Helen C., Crémisi, Chantal

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Update on HER-2 as a target for cancer therapy: the ERBB2 promoter and its exploitation for cancer treatment by Hurst, H C

“…Overexpression of the ERBB2 proto-oncogene is associated with amplification of the gene in breast cancer but increased activity of the promoter also plays a…”
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The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma by Bosher, J M, Williams, T, Hurst, H C

“…Overexpression of the c-erbB-2/HER2 protooncogene in breast carcinoma is controlled not only by the degree of amplification of the gene but also at the level…”
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Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways by TURNER, B. C, JIAN ZHANG, GUMBS, A. A, MAHER, M. G, KAPLAN, L, CARTER, D, GLAZER, P. M, HURST, H. C, HAFFTY, B. G, WILLIAMS, T

“…The AP-2 transcription factors are required for normal growth and morphogenesis during mammalian development. Previous in vitro studies have also indicated…”
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Genetic Prodrug Activation Therapy for Breast Cancer: A Phase I Clinical Trial of erbB-2–Directed Suicide Gene Expression by PANDHA, H. S, MARTIN, L.-A, RIGG, A, HURST, H. C, STAMP, G. W. H, SIKORA, K, LEMOINE, N. R

“…This trial was designed to test the safety and efficacy of a tumor-specific genetic prodrug activation therapy targeted by use of the human erbB-2 gene…”
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FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1α by SHAH, Riyaz N. H, IBBITT, J. Claire, ALITALO, Kari, HURST, Helen C

“…Fibroblast growth factor receptor 4 (FGFR4) is expressed in 50–70% of pancreatic carcinomas (PC) and a similar proportion of derived cell lines. Here we…”
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Tumour-selective transcriptional targeting for breast cancer gene therapy by Hurst, HC

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Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer by NEWMAN, S. P, BATES, N. P, VERNIMMEN, D, PARKER, M. G, HURST, H. C

“…Overexpression of the ERBB2 proto-oncogene in breast tumours, which occurs in 25-30% of patients, correlates with poor prognosis. In oestrogen receptor (ER)…”
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