Search Results - "Hurst, H C"

Overexpression of TFAP2C in invasive breast cancer correlates with a poorer response to anti-hormone therapy and reduced patient survival by Gee, JMW, Eloranta, JJ, Ibbitt, JC, Robertson, JFR, Ellis, IO, Williams, T, Nicholson, RI, Hurst, HC

“…The AP-2γ transcription factor encoded by the TFAP2C gene is a member of a family of homologous DNA binding proteins that play essential roles during…”
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Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types by Srinivasan, Radhika, Poulsom, Richard, Hurst, Helen C., Gullick, William J.

“…The c‐erbB‐4/HER4 receptor belongs to the family of the type I growth factor receptors. Mouse monoclonal antibodies have been raised to the cytoplasmic domain…”
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Insulation of a conditionally expressed transgene in an adenoviral vector by VASSAUX, G, HURST, H. C, LEMOINE, N. R

“…Replication-defective recombinant adenoviruses provide an efficient system for in vivo gene transfer and numerous studies have demonstrated that this vector…”
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Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Pregnant Long Evans Rats: Association of Measured Tissue Concentrations with Developmental Effects by Hurst, Christopher H., DeVito, Michael J., Setzer, R. Woodrow, Birnbaum, Linda S.

“…Prenatal exposure to TCDD interferes with fetal development at doses lower than those causing overt toxicity in adult animals. Exposure to TCDD during…”
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Expression of the ERBB3 gene product in breast cancer by LEMOINE, N. R, BARNES, D. M, HOLLYWOOD, D. P, HUGHES, C. M, SMITH, P, DUBLIN, E, PRIGENT, S. A, GULLICK, W. J, HURST, H. C

“…Abnormalities of the EGF receptor and/or the related ERBB2 receptor occur in a significant proportion of cases of human breast cancer and are important…”
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Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer by Wong, P-P, Yeoh, C C, Ahmad, A S, Chelala, C, Gillett, C, Speirs, V, Jones, J L, Hurst, H C

“…The antiestrogen tamoxifen is a well-tolerated, effective treatment for estrogen receptor-α-positive (ER+) breast cancer, but development of resistance…”
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Transcriptional repression by a novel member of the bZIP family of transcription factors by COWELL, I. G, SKINNER, A, HURST, H. C

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma by Bosher, J M, Williams, T, Hurst, H C

“…Overexpression of the c-erbB-2/HER2 protooncogene in breast carcinoma is controlled not only by the degree of amplification of the gene but also at the level…”
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Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways by TURNER, B. C, JIAN ZHANG, GUMBS, A. A, MAHER, M. G, KAPLAN, L, CARTER, D, GLAZER, P. M, HURST, H. C, HAFFTY, B. G, WILLIAMS, T

“…The AP-2 transcription factors are required for normal growth and morphogenesis during mammalian development. Previous in vitro studies have also indicated…”
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A toolset of aequorin expression vectors for in planta studies of subcellular calcium concentrations in Arabidopsis thaliana by Mehlmer, Norbert, Parvin, Nargis, Hurst, Charlotte H, Knight, Marc R, Teige, Markus, Vothknecht, Ute C

“…Calcium has long been acknowledged as one of the most important signalling components in plants. Many abiotic and biotic stimuli are transduced into a cellular…”
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Genetic Prodrug Activation Therapy for Breast Cancer: A Phase I Clinical Trial of erbB-2–Directed Suicide Gene Expression by PANDHA, H. S, MARTIN, L.-A, RIGG, A, HURST, H. C, STAMP, G. W. H, SIKORA, K, LEMOINE, N. R

“…This trial was designed to test the safety and efficacy of a tumor-specific genetic prodrug activation therapy targeted by use of the human erbB-2 gene…”
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Tissue disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in maternal and developing Long-Evans rats following subchronic exposure by HURST, Christopher H, DEVITO, Michael J, BIRNBAUM, Linda S

“…Prenatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) produces alterations in the reproductive system of the developing pups. The objective of this…”
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Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer by NEWMAN, S. P, BATES, N. P, VERNIMMEN, D, PARKER, M. G, HURST, H. C

“…Overexpression of the ERBB2 proto-oncogene in breast tumours, which occurs in 25-30% of patients, correlates with poor prognosis. In oestrogen receptor (ER)…”
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Immunohistochemical analysis reveals a tumour suppressor-like role for the transcription factor AP-2 in invasive breast cancer by Gee, Julia M. W., Robertson, John F. R., Ellis, Ian O., Nicholson, Robert I., Hurst, Helen C.

“…This paper describes the generation and characterization of a monoclonal antibody specific for two members of the AP‐2 family of transcription factors, AP‐2α…”
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Transcription factors 1: bZIP proteins by Hurst, H C

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Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter by Ring, C J, Harris, J D, Hurst, H C, Lemoine, N R

“…In order to exploit the tumour-specific nature of ERBB2 expression for genetic prodrug-activation therapy, we have generated recombinant adenoviral, retroviral…”
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Pathways of hepatic oxalate synthesis and their regulation by Poore, R E, Hurst, C H, Assimos, D G, Holmes, R P

“…Important features of hepatic oxalate synthesis remain uncertain despite its clinical significance. To clarify the terminal steps of the biosynthetic pathway…”
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A Cellular Protein, Activating Transcription Factor, Activates Transcription of Multiple E1A-Inducible Adenovirus Early Promoters by Kevin A. W. Lee, Hai, Tsong-Yuing, SivaRaman, Lakshmi, Thimmappaya, Bayar, Hurst, Helen C., Jones, Nicolas C., Green, Michael R.

“…We have examined the relationship between sequence-specific DNA-binding proteins that activate trascription of E1A-inducible adenovirus early promoters…”
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The cellular transcription factor CREB corresponds to activating transcription factor 47 (ATF-47) and forms complexes with a group of polypeptides related to ATF-43 by HURST, H. C, MASSON, N, JONES, N. C, LEE, K. A. W

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcription factors as drug targets in cancer by Hurst, H.C.

“…Within multicellular organisms, cells are continually signalling to each other to keep in tune with their environment. The ultimate targets for the majority of…”
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