Search Results - "Hurst, Douglas R."

Defining the Hallmarks of Metastasis by Welch, Danny R, Hurst, Douglas R

“…Metastasis is the primary cause of cancer morbidity and mortality. The process involves a complex interplay between intrinsic tumor cell properties as well as…”
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Metastamir: The Field of Metastasis-Regulatory microRNA Is Spreading by HURST, Douglas R, EDMONDS, Mick D, WELCH, Danny R

“…Despite advancements in knowledge from more than a century of metastasis research, the genetic programs and molecular mechanisms required for cancer metastasis…”
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Breast Cancer Metastasis Suppressor 1 Up-regulates miR-146, Which Suppresses Breast Cancer Metastasis by HURST, Douglas R, EDMONDS, Mick D, SCOTT, Gary K, BENZ, Christopher C, VAIDYA, Kedar S, WELCH, Danny R

“…Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that differentially regulates expression of multiple genes, leading to…”
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Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells by Cody, James J, Markert, James M, Hurst, Douglas R

“…New therapies are needed for metastatic breast cancer patients. Oncolytic herpes simplex virus (oHSV) is an exciting therapy being developed for use against…”
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Long Noncoding RNA HITTERS Protects Oral Squamous Cell Carcinoma Cells from Endoplasmic Reticulum Stress‐Induced Apoptosis via Promoting MRE11‐RAD50‐NBS1 Complex Formation by Wu, Chenzhou, Chen, Wen, Yu, Fanyuan, Yuan, Yihang, Chen, Yafei, Hurst, Douglas R., Li, Yi, Li, Longjiang, Liu, Zhe

“…Recent studies have proven that long noncoding RNAs (lncRNAs) exhibit regulatory functions of both DNA damage response (DDR) and endoplasmic reticulum (ER)…”
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Perturbation of BRMS1 interactome reveals pathways that impact metastasis by Zimmermann, Rosalyn C, Sardiu, Mihaela E, Manton, Christa A, Miah, Md Sayem, Banks, Charles A S, Adams, Mark K, Koestler, Devin C, Hurst, Douglas R, Edmonds, Mick D, Washburn, Michael P, Welch, Danny R

“…Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality…”
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SIN3A and SIN3B differentially regulate breast cancer metastasis by Lewis, Monica J, Liu, Jianzhong, Libby, Emily Falk, Lee, Minnkyong, Crawford, Nigel P S, Hurst, Douglas R

“…SIN3 corepressor complexes play important roles in both normal development and breast cancer. Mammalian cells have two paralogs of SIN3 (SIN3A and SIN3B) that…”
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SOCS3 Deficiency in Myeloid Cells Promotes Tumor Development: Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells by Yu, Hao, Liu, Yudong, McFarland, Braden C, Deshane, Jessy S, Hurst, Douglas R, Ponnazhagan, Selvarangan, Benveniste, Etty N, Qin, Hongwei

“…Suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway and generally function as tumor suppressors. The absence of…”
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Mitochondrial bioenergetics of metastatic breast cancer cells in response to dynamic changes in oxygen tension: effects of HIF-1α by Diers, Anne R, Vayalil, Praveen K, Oliva, Claudia R, Griguer, Corinne E, Darley-Usmar, Victor, Hurst, Douglas R, Welch, Danny R, Landar, Aimee

“…Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects…”
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Re-expression of DIRAS3 and p53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma by Liu, Zhe, Hurst, Douglas R, Qu, Xing, Lu, Li-Guang, Wu, Chen-Zhou, Li, Yu-Yu, Li, Yi

“…p53 and DIRAS3 are tumor suppressors that are frequently silenced in tumors. In this study, we sought to determine whether the concurrent re-expression of p53…”
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Globular adiponectin enhances invasion in human breast cancer cells by FALK LIBBY, EMILY, LIU, JIANZHONG, LI, YI, LEWIS, MONICA J, DEMARK-WAHNEFRIED, WENDY, HURST, DOUGLAS R

“…Every year, a large number of women succumb to metastatic breast cancer due to a lack of curative approaches for this disease. Adiponectin (AdipoQ) is the most…”
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The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression by Hurst, Douglas R, Xie, Yi, Thomas, John W, Liu, Jianzhong, Edmonds, Mick D, Stewart, Mark D, Welch, Danny R

“…Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that suppresses metastasis in multiple human and murine carcinoma cell lines…”
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Alterations of BRMS1-ARID4A Interaction Modify Gene Expression but Still Suppress Metastasis in Human Breast Cancer Cells by Hurst, Douglas R., Xie, Yi, Vaidya, Kedar S., Mehta, Alka, Moore, Blake P., Accavitti-Loper, Mary Ann, Samant, Rajeev S., Saxena, Ritu, Silveira, Alexandra C., Welch, Danny R.

“…The BRMS1 metastasis suppressor interacts with the protein AT-rich interactive domain 4A (ARID4A, RBBP1) as part of SIN3·histone deacetylase chromatin…”
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Breast Cancer Metastasis Suppressor-1 Differentially Modulates Growth Factor Signaling by Vaidya, Kedar S., Harihar, Sitaram, Phadke, Pushkar A., Stafford, Lewis J., Hurst, Douglas R., Hicks, David G., Casey, Graham, DeWald, Daryll B., Welch, Danny R.

“…That metastatic tumor cells grow in selective non-native environments suggests an ability to differentially respond to local microenvironments. BRMS1, like…”
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Linking metastasis suppression with metastamiR regulation by Edmonds, Mick D., Hurst, Douglas R., Welch, Danny R.

“…Cancer metastasis requires the coordinate expression of multiple genes during every step of the metastatic cascade. Molecules that regulate these genetic…”
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Metastasis suppressor genes at the interface between the environment and tumor cell growth by Hurst, Douglas R, Welch, Danny R

“…The molecular mechanisms and genetic programs required for cancer metastasis are sometimes overlapping, but components are clearly distinct from those…”
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Heparanase-mediated Loss of Nuclear Syndecan-1 Enhances Histone Acetyltransferase (HAT) Activity to Promote Expression of Genes That Drive an Aggressive Tumor Phenotype by Purushothaman, Anurag, Hurst, Douglas R., Pisano, Claudio, Mizumoto, Shuji, Sugahara, Kazuyuki, Sanderson, Ralph D.

“…Heparanase acts as a master regulator of the aggressive tumor phenotype in part by enhancing expression of proteins known to drive tumor progression (e.g…”
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Metastasis suppression by BRMS1 associated with SIN3 chromatin remodeling complexes by Hurst, Douglas R.

“…Epigenetic regulation of gene transcription by histone modification and chromatin remodeling has been linked to many biological and pathological events…”
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miR-31 Displays Subtype Specificity in Lung Cancer by Davenport, Mackenzie L, Echols, John B, Silva, Austin D, Anderson, Joshua C, Owens, Philip, Yates, Clayton, Wei, Qing, Harada, Shuko, Hurst, Douglas R, Edmonds, Mick D

“…miRNA rarely possess pan-oncogenic or tumor-suppressive properties. Most miRNAs function under tissue-specific contexts, acting as either tumor suppressors in…”
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Suppression of SIN3A by miR-183 Promotes Breast Cancer Metastasis by Davenport, Mackenzie L, Davis, Mara R, Davenport, Baylea N, Crossman, David K, Hall, Aaron, Pike, Jason, Harada, Shuko, Hurst, Douglas R, Edmonds, Mick D

“…Recent work has established that SWI-independent-3 (SIN3) chromatin modification complexes play key roles in cancer progression. We previously demonstrated…”
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