Search Results - "Hurski, Alaksiej"

Visible-Light-Promoted Nickel-Catalyzed Cross-Coupling of Alkyltitanium Alkoxides with Aryl and Alkenyl Halides by Leushukou, Andrei A., Krech, Anastasiya V., Hurski, Alaksiej L.

“…Here, we report that alkyltitanium alkoxides generated in situ from Grignard reagents and Ti­(OiPr)4 undergo a photocatalyst-free nickel-catalyzed…”
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Visible‐Light‐Promoted Catalytic Ring‐Opening Isomerization of 1,2‐Disubstituted Cyclopropanols to Linear Ketones by Laktsevich‐Iskryk, Marharyta V., Varabyeva, Nastassia A., Kazlova, Volha V., Zhabinskii, Vladimir N., Khripach, Vladimir A., Hurski, Alaksiej L.

“…Isomerization to linear ketones is a valuable transformation of 1,2‐disubstituted cyclopropanols proceeding through radical intermediates. Despite simplicity…”
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A photochemical approach to 18-nor-17β-hydroxymethyl-17α-methylandrost-13-ene steroids by Laktsevich-Iskryk, Marharyta V., Rudovich, Anton S., Zhabinskii, Vladimir N., Khripach, Vladimir A., Hurski, Alaksiej L.

“…[Display omitted] •Photochemical C17 functionalization of 18-nor-13-ene steroids was explored.•New approach to…”
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Palladium‐Catalyzed 2‐(Neopentylsulfinyl)aniline Directed C–H Acetoxylation and Alkenylation of Arylacetamides by Barysevich, Maryia V., Laktsevich‐Iskryk, Marharyta V., Krech, Anastasiya V., Zhabinskii, Vladimir N., Khripach, Vladimir A., Hurski, Alaksiej L.

“…The 2‐(neopentylsulfinyl)aniline directing group that promotes rapid palladium‐catalyzed C–H acetoxylation and alkenylation of arylacetamides has been…”
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Synthesis and biological activity of 21,22-cyclosteroids and their derivatives by Barysevich, Maryia V., Laktsevich-Iskryk, Marharyta V., Scherbakov, Alexander M., Salnikova, Diana I., Andreeva, Olga E., Sorokin, Danila V., Shchegolev, Yuri Y., Hurski, Alaksiej L., Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…•Synthesis of 21,22-cyclosteroids was achieved starting from pregnenolone acetate.•Key transformation was the Kulinkovich reaction of 17-vinyl steroids with…”
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New azole derivatives of [17(20)E]-21-norpregnene: Synthesis and inhibition of prostate carcinoma cell growth by Dalidovich, Tatsiana S., Hurski, Alaksiej L., Morozevich, Galina E., Latysheva, Alexandra S., Sushko, Tatsiana A., Strushkevich, Natallia V., Gilep, Andrei A., Misharin, Alexander Y., Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…[Display omitted] A number of isoxazole, 1,2,3-triazole, tetrazole, and 1,2,4-oxadiazole derivatives of [17(20)E]-21-norpregnene comprising 3β-hydroxy-5-ene…”
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Enantioselective catalytic approach to the C23–C28 subunit of 24α-methyl steroids by Yakimchyk, Viktoryia S., Kazlova, Volha V., Hurski, Alaksiej L., Savchenko, Rimma G., Kostyleva, Svetlana A., Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…[Display omitted] •A new catalytic way to C23–C28 fragment of campestanes is reported.•Two ways of reductive denitromethylation have been developed.•The…”
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Regio- and stereoselective C–H functionalization of brassinosteroids by Hurski, Alaksiej L., Kukel, Aliaksandr G., Liubina, Aliaksandra I., Baradzenka, Aliona G., Straltsova, Darya, Demidchik, Vadim, Drašar, Pavel, Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…[Display omitted] •Rhodium-catalyzed CH amination of brassinosteroids proceeds regio- and stereoselectively.•15α-substituted brassinosteroids are formed in the…”
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C−H Acetoxylation-Based Chemical Synthesis of 17 β-Hydroxymethyl-17 α-methyl-18-norandrost-13-ene Steroids by Hurski, Alaksiej L., Barysevich, Maryia V., Dalidovich, Tatsiana S., Iskryk, Marharyta V., Kolasava, Nastassia U., Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…Palladium‐catalyzed C−H acetoxylation has been proposed as a key transformation in the first chemical synthesis of steroids bearing a unique…”
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A strong developmental isotope effect in Caenorhabditis elegans induced by 5,5-deuterated lysine by Korneenko, Tatyana V., Pestov, Nikolay B., Hurski, Alaksiej L., Fedarkevich, Artsiom M., Shmanai, Vadim V., Brenna, J. Thomas, Shchepinov, Mikhail S.

“…Effects exerted by heavy isotope substitution in biopolymers on the functioning of whole organisms have not been investigated. We report on the decrease of…”
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Synthesis of brassinosteroids with a keto group in the side chain by Baradzenka, Aliona G., Barysau, Barys M., Hurski, Alaksiej L., Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…[Display omitted] •Cyclic mono- and dicarbonate of epibrassinolide were prepared.•An effective cleavage of 22,23-cyclic boric ester was achieved.•A procedure…”
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A new approach to the side chain formation of 24-alkyl-22-hydroxy steroids: Application to the preparation of early brassinolide biosynthetic precursors by Hurski, Alaksiej L., Zhabinskii, Vladimir N., Khripach, Vladimir A.

“…[Display omitted] ► A new synthetic route to 22S-hydroxy-24R-methyl steroids has been developed. ► 22-Hydroxy-23,26-thioderivatives were used as key…”
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A cyclopropanol approach to the synthesis of both enantiomers of the C13–C21 fragment of epothilones by Hurski, Alaksiej L., Sokolov, Nikolai A., Kulinkovich, Oleg G.

“…Efficient syntheses of both enantiomers of the C13–C21 fragment of epothilone molecules have been performed by use of enantiomeric oxiranyl-substituted…”
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Control of lysyl oxidase activity through site-specific deuteration of lysine by Pestov, Nikolay B., Okkelman, Irina A., Shmanai, Vadim V., Hurski, Alaksiej L., Giaccia, Amato J., Shchepinov, Mikhail S.

“…Lysyl oxidase (LOX) is implicated in several extracellular matrix related disorders, including fibrosis and cancer. Methods of inhibition of LOX in vivo…”
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Palladium-catalyzed reactions of cyclopropanols bearing oxazoline directing group by Novikau, Ilya, Hurski, Alaksiej

“…Cyclopropanols bearing oxazoline directing group were investigated in palladium-catalyzed reactions. When the directing group and cyclopropanol unit were…”
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Synthetic studies toward Swinhoeisterol A: Synthesis of the 6/6/5/7 tetracyclic core by Kazlova, Volha V., Hurski, Alaksiej L.

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Construction of tetralin and chromane cores by the Lewis acid promoted ring-opening cyclization of cyclopropyl methanesulfonates by Novikau, Ilya, Leushukou, Andrei, Tsiuryn, Mikita, Hurski, Alaksiej

“…[Display omitted] Rearrangement of cyclopropyl methanesulfonates to allylic carbocations was employed for the construction of tetralin and chromate bicyclic…”
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Ti(OiPr)4‑Enabled Dual Photoredox and Nickel-Catalyzed Arylation and Alkenylation of Cyclopropanols by Varabyeva, Nastassia, Barysevich, Maryia, Aniskevich, Yauhen, Hurski, Alaksiej

“…Readily available from esters or ketones, cyclopropanols are inclined to undergo diverse ring-opening transformations. Their one-electron oxidation is a…”
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Visible-Light-Promoted Reduction of Epoxides, Hydroxysulfonates, and Halohydrines with Alkyltitanium Alkoxides by Mikhaliov, Artyom, Flerko, Aliaksei, Atroshchanka, Dziyana, Harakhouski, Aliaksei, Budko, Arsenii, Stasko, Kirill, Bialkevich, Andrei, Shepialevich, Siarhei, Rusakovich, Yahor, Hurski, Alaksiej

“…Alkyltitanium alkoxides generally serve as nucleophiles in reactions with carbonyl compounds and cross-coupling. Their application as reductants is known but…”
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Ligand Enabled Manganese‐Catalyzed Oxidation of 1,2‐Disubstituted Cyclobutanols by Karotsina, Ulada, Pilicheva, Margarita, Hurski, Alaksiej, Astashko, Dmitry

“…Here we report a protocol for the preparation of 1,4‐diketones from 1,2‐disubstituted cyclobutanols based on their ring‐opening oxidation with molecular…”
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