Search Results - "Hurrish, Katie Hege"

Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia by Hege Hurrish, Katie, Qiao, Xinan, Li, Xinyu, Su, Yongwei, Carter, Jenna, Ma, Jun, Kalpage, Hasini A., Hüttemann, Maik, Edwards, Holly, Wang, Guan, Kim, Seongho, Dombkowski, Alan, Bao, Xun, Li, Jing, Taub, Jeffrey W., Ge, Yubin

“…[Display omitted] Despite the recently approved new therapies, the clinical outcomes of acute myeloid leukemia (AML) patients remain disappointing,…”
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The imipridone ONC213 targets α-ketoglutarate dehydrogenase to induce mitochondrial stress and suppress oxidative phosphorylation in acute myeloid leukemia by Su, Yongwei, Carter, Jenna L, Li, Xinyu, Fukuda, Yu, Gray, Ashley, Lynch, John, Edwards, Holly, Ma, Jun, Schreiner, Patrick, Polin, Lisa, Kushner, Juiwanna, Dzinic, Sijana H, Buck, Steven A, Pruett-Miller, Shondra M, Hurrish, Katie Hege, Robinson, Camenzind, Qiao, Xinan, Liu, Shuang, Wu, Shuangshuang, Wang, Guan, Li, Jing, Allen, Joshua E, Prabhu, Varun V, Schimmer, Aaron D, Joshi, Dhananjay, Kalhor-Monfared, Shiva, Watson, Iain D G, Marcellus, Richard, Isaac, Methvin B, Al-Awar, Rima, Taub, Jeffrey W, Lin, Hai, Schuetz, John D, Ge, Yubin

“…Eradication of acute myeloid leukemia (AML) is therapeutically challenging; many patients succumb to AML despite initially responding to conventional…”
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Enhancing the Antileukemic Activity of the Bcl-2 Inhibitor, Venetoclax, Against Acute Myeloid Leukemia by Hurrish, Katie Hege

“…The 5-year overall survival rate for adults with acute myeloid leukemia (AML) is only 27% and most new patients cannot tolerate the intensive standard…”
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A Novel Isoflavone, ME-344, Enhances Venetoclax Antileukemic Activity Against AML Via Suppression of Oxidative Phosphorylation and Purine Biosynthesis by Hege Hurrish, Katie, Su, Yongwei, Wiley, Sandra, Hou, Zhanjun, Carter, Jenna, Kalpage, Hasini, Hüttemann, Maik, Edwards, Holly, Polin, Lisa, Li, Jing, Yang, Jay, Matherly, Larry, Taub, Jeffrey W., Ge, Yubin

“…The 5-year survival rate for adult patients with acute myeloid leukemia (AML) treated with cytarabine-based chemotherapy remains less than 30%, due to drug…”
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