Hypoglycaemic effect of Momordica charantia extracts in normoglycaemic or cyproheptadine-induced hyperglycaemic mice

The hypoglycaemic effect of orally administered extracts of Momordica charantia L. fruits was examined in normoglycaemic or cyproheptadine-induced hyperglycaemic mice. The aqueous extract reduced the fasting glucose levels of hyperglycaemic or normoglycaemic mice. However, the ethanol extract did no...

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Bibliographic Details
Published in:	Journal of ethnopharmacology Vol. 44; no. 2; p. 117
Main Authors:	Cakici, I, Hurmoğlu, C, Tunçtan, B, Abacioğlu, N, Kanzik, I, Sener, B
Format:	Journal Article
Language:	English
Published:	Ireland 01-10-1994
Subjects:	Animals Blood Glucose - analysis Cyproheptadine Hyperglycemia - blood Hyperglycemia - chemically induced Hyperglycemia - drug therapy Hypoglycemic Agents - pharmacology Male Mice N-Glycosyl Hydrolases Plant Extracts - pharmacology Plant Proteins - pharmacology Ribosome Inactivating Proteins, Type 2
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Summary:	The hypoglycaemic effect of orally administered extracts of Momordica charantia L. fruits was examined in normoglycaemic or cyproheptadine-induced hyperglycaemic mice. The aqueous extract reduced the fasting glucose levels of hyperglycaemic or normoglycaemic mice. However, the ethanol extract did not affect the fasting or nonfasting glucose levels significantly in both groups of mice. There was no significant difference between the glucose-loaded and glucose-loaded plus aqueous extract given group. On the other hand, oral glucose-loading of the cyproheptadine-induced hyperglycaemic animals reduced the fasting glucose levels significantly. These results showed that aqueous extract of M. charantia fruits has a hypoglycaemic activity without improving the tolerance to glucose in cyproheptadine-induced diabetic mice.
ISSN:	0378-8741
DOI:	10.1016/0378-8741(94)90077-9