Search Results - "Hurme, M"

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study by Kananen, L, Marttila, S, Nevalainen, T, Jylhävä, J, Mononen, N, Kähönen, M, Raitakari, O T, Lehtimäki, T, Hurme, M

“…Chronological aging-associated changes in the human DNA methylome have been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites…”
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Inherent occupational health assessment during process research and development stage by Hassim, M.H., Hurme, M.

“…Occupational health studies the interaction of work and health, especially the long-term effect of chemicals to health. In this paper an Inherent Occupational…”
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Plasma level of soluble urokinase‐type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study by Huttunen, R., Syrjänen, J., Vuento, R., Hurme, M., Huhtala, H., Laine, J., Pessi, T., Aittoniemi, J.

“…Huttunen R, Syrjänen J, Vuento R, Hurme M, Huhtala H, Laine J, Pessi T, Aittoniemi J (Tampere University Hospital; University of Tampere Medical School,…”
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Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains by Kananen, L., Enroth, L., Raitanen, J., Jylhävä, J., Bürkle, A., Moreno-Villanueva, M., Bernhardt, J., Toussaint, O., Grubeck-Loebenstein, B., Malavolta, M., Basso, A., Piacenza, F., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Jansen, E. H. J. M., Dollé, M. E. T., Salmon, M., Stuetz, W., Weber, D., Grune, T., Breusing, N., Simm, A., Capri, M., Franceschi, C., Slagboom, P. E., Talbot, D. C. S., Libert, C., Koskinen, S., Bruunsgaard, H., Hansen, ÅM., Lund, R., Hurme, M., Jylhä, M.

“…Self-rated health (SRH) is one of the most frequently used indicators in health and social research. Its robust association with mortality in very different…”
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Plasma cell‐free DNA and qSOFA score predict 7‐day mortality in 481 emergency department bacteraemia patients by Rannikko, J., Seiskari, T., Huttunen, R., Tarkiainen, I., Jylhävä, J., Hurme, M., Syrjänen, J., Aittoniemi, J.

“…Background A few studies have shown that both quick Sequential Organ Failure Assessment (qSOFA) score and cell‐free DNA (cfDNA) have potential use as a…”
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Circulating cell-free DNA level predicts all-cause mortality independent of other predictors in the Health 2000 survey by Kananen, L., Hurme, M., Jylhä, M., Härkänen, T., Koskinen, S., Stenholm, S., Kähönen, M., Lehtimäki, T., Ukkola, O., Jylhävä, J.

“…Increased levels of circulating cell-free DNA (cf-DNA) are associated with and predict poor health outcomes. However, its predictive ability for mortality in…”
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Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG by Pessi, T., Sütas, Y., Hurme, M., Isolauri, E.

“…Oral Lactobacillus rhamnosus GG ingestion for 5 days to 4 weeks has been shown to alleviate clinical symptoms of gastrointestinal inflammation and atopic…”
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Inflammatory Markers and Physical Performance Among Nonagenarians by Tiainen, Kristina, Hurme, Mikko, Hervonen, Antti, Luukkaala, Tiina, Jylhä, Marja

“…Background. Recent studies have suggested that inflammation may play an important role in aging and the development of disabilities, but knowledge about its…”
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Increased plasma levels of cytokines after seizures in localization-related epilepsy by Lehtimäki, K. A., Keränen, T., Palmio, J., Mäkinen, R., Hurme, M., Honkaniemi, J., Peltola, J.

“…Objectives –  Experimental studies suggest increased cerebral production of inflammatory cytokines after prolonged seizures. Whether a single non‐prolonged…”
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The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies by Kananen, L., Marttila, S., Nevalainen, T., Kummola, L., Junttila, I., Mononen, N., Kähönen, M., Raitakari, O. T., Hervonen, A., Jylhä, M., Lehtimäki, T., Hurme, M., Jylhävä, J.

“…The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of…”
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Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study by Nevalainen, T., Kananen, L., Marttila, S., Jylhä, M., Hervonen, A., Hurme, M., Jylhävä, J.

“…Aging is associated with a pro-inflammatory state, often referred to as inflammaging. The origin of the pro-inflammatory mediators and their role in the…”
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Presence of the IL‐1RA Allele 2 (IL1RN2) is Associated with Enhanced IL‐1β Production In Vitro by Santtila, S, Savinainen, K, Hurme, M

“…The genes of the interleukin‐1 (IL‐1) complex code for three proteins: IL‐1α, IL‐1β and the IL‐1 receptor antagonist (IL‐1RA). Each of these genes is…”
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Accident prevention approach throughout process design life cycle by Kidam, K., Hussin, N.E., Hassan, O., Ahmad, A., Johari, A., Hurme, M.

“…•Earlier study shows that the accident contributors are originated throughout process design lifecycle.•The paper presents a new lifecycle approach based on…”
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Allergic sensitization and microbial load - a comparison between Finland and Russian Karelia by Seiskari, T, Kondrashova, A, Viskari, H, Kaila, M, Haapala, A.-M, Aittoniemi, J, Virta, M, Hurme, M, Uibo, R, Knip, M, Hyöty, H

“…Epidemiological data have indicated that some infections are associated with a low risk of allergic diseases, thus supporting the idea (hygiene hypothesis)…”
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Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease by HULKKONEN, J, PERTOVAARA, M, ANTONEN, J, PASTERNACK, A, HURME, M

“…To determine whether plasma interleukin-6 (IL-6) and G/C base exchange polymorphism at position -174 of the IL6 gene have an effect on the clinical…”
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Indoleamine 2,3‐dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study by Pertovaara, M., Raitala, A., Juonala, M., Lehtimäki, T., Huhtala, H., Oja, S. S., Jokinen, E., Viikari, J. S. A., Raitakari, O. T., Hurme, M.

“…Summary Indoleamine 2,3 dioxygenase (IDO), an enzyme involved in the catabolism of tryptophan, suppresses T cell activity and is up‐regulated by various…”
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Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration by Lehtimäki, K.A, Keränen, T, Huhtala, H, Hurme, M, Ollikainen, J, Honkaniemi, J, Palmio, J, Peltola, J

“…Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its…”
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Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression by Anttila, S, Huuhka, K, Huuhka, M, Rontu, R, Hurme, M, Leinonen, E, Lehtimäki, T

“…Several studies have linked 5-HT1A C1019G and BDNF G196A (Val66Met) gene polymorphisms to major depressive disorder (MDD) and the actions of antidepressants…”
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Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow‐mediated dilation in young men: the Cardiovascular Risk in Young Finns Study by Haarala, A., Kähönen, M., Lehtimäki, T., Aittoniemi, J., Jylhävä, J., Hutri‐Kähönen, N., Taittonen, L., Laitinen, T., Juonala, M., Viikari, J., Raitakari, O. T., Hurme, M.

“…Summary Human cytomegalovirus (CMV) infection is associated with a higher risk of cardiovascular disease in immunocompromised organ transplant patients. It has…”
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The rs2516839 variation of USF1 gene is associated with 4‐year mortality of nonagenarian women: The Vitality 90+ study by Ozsait‐Selcuk, B., Komurcu‐Bayrak, E., Jylhä, M., Luukkaala, T., Perola, M., Kristiansson, K., Mononen, N., Hurme, M., Kähönen, M., Goebeler, S., Laaksonen, R., Hervonen, A., Erginel‐Unaltuna, N., Karhunen, P.J., Lehtimäki, T.

“…Upstream transcription factor 1 (USF1) regulates the transcription of many genes related to cell and organism survival processes such as stress and immune…”
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