Search Results - "Hurley, Miriam E."

Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease by Hurley, Miriam E, White, Ed, Sheard, Thomas M D, Steele, Derek, Jayasinghe, Izzy

“…Rapid release of calcium from internal stores via ryanodine receptors (RyRs) is one of the fastest types of cytoplasmic second messenger signalling in…”
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Super-Resolution Analysis of the Origins of the Elementary Events of ER Calcium Release in Dorsal Root Ganglion Neurons by Hurley, Miriam E, Shah, Shihab S, Sheard, Thomas M D, Kirton, Hannah M, Steele, Derek S, Gamper, Nikita, Jayasinghe, Izzy

“…Coordinated events of calcium (Ca ) released from the endoplasmic reticulum (ER) are key second messengers in excitable cells. In pain-sensing dorsal root…”
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Three-dimensional visualization of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads by Sheard, Thomas M D, Hurley, Miriam E, Smith, Andrew J, Colyer, John, White, Ed, Jayasinghe, Izzy

“…Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular machinery of intracellular calcium signalling in cardiomyocytes. While a…”
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A correlative super-resolution protocol to visualise structural underpinnings of fast second-messenger signalling in primary cell types by Hurley, Miriam E., Sheard, Thomas M.D., Norman, Ruth, Kirton, Hannah M., Shah, Shihab S., Pervolaraki, Eleftheria, Yang, Zhaokang, Gamper, Nikita, White, Ed, Steele, Derek, Jayasinghe, Izzy

“…•The imaging protocol visualises intracellular calcium signals and their sources.•It correlates calcium spark TIRF images with DNA-PAINT images of RyR…”
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Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy by Sheard, Thomas M. D, Hurley, Miriam E, Colyer, John, White, Ed, Norman, Ruth, Pervolaraki, Eleftheria, Narayanasamy, Kaarjel K, Hou, Yufeng, Kirton, Hannah M, Yang, Zhaokang, Hunter, Liam, Shim, Jung-uk, Clowsley, Alexander H, Smith, Andrew J, Baddeley, David, Soeller, Christian, Colman, Michael A, Jayasinghe, Izzy

“…Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine…”
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Involvement of the purkinje fibres in the development of ventricular arrhythmias upon mechanical stimulation by Hurley, Miriam E., Kaur, Sarbjot, Power, Amelia, Walton, Richard D., Haïssaguerre, Michel, Bernus, Olivier, Ward, Marie-Louise, White, Ed

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Sub-cellular Heterogeneity in SERCA Determines Spatial Calcium Dynamics in Cardiomyocytes by Holmes, Maxx, Hurley, Miriam E., Sheard, Tom M.D., Stevenson-Cocks, Harley J., Benson, Al, Jayasinghe, Izzy, Colman, Michael A.

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Optical Superresolution Analysis of Intracellular Calcium Handling Proteins and Correlating Calcium Signal Morphology by Hurley, Miriam E., Sheard, Thomas M., Norman, Ruth, Kirton, Hannah M., Shah, Shihab S., Pervolaraki, Eleftheria, Yang, Zhaokang, Steele, Derek S., Gamper, Nikita, White, Ed, Jayasinghe, Izzy

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