Search Results - "Hurley, Michael J"

Calcium Channel Antagonists as Disease-Modifying Therapy for Parkinson’s Disease: Therapeutic Rationale and Current Status by Swart, Tara, Hurley, Michael J.

“…Parkinson’s disease is a disabling hypokinetic neurological movement disorder in which the aetiology is unknown in the majority of cases. Current…”
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Altered Gut Microbiota in a Fragile X Syndrome Mouse Model by Altimiras, Francisco, Garcia, José Antonio, Palacios-García, Ismael, Hurley, Michael J., Deacon, Robert, González, Bernardo, Cogram, Patricia

“…The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to…”
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Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice by Cogram, Patricia, Alkon, Daniel L., Crockford, David, Deacon, Robert M. J., Hurley, Michael J., Altimiras, Francisco, Sun, Miao-Kun, Tranfaglia, Michael

“…Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a…”
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Neuroprotective role for RORA in Parkinson’s disease revealed by analysis of post-mortem brain and a dopaminergic cell line by Al-Zaid, Felwah S., Hurley, Michael J., Dexter, David T., Gillies, Glenda E.

“…Parkinson’s disease (PD) is almost twice as prevalent in men, which has largely been attributed to neuroprotective effect of oestradiol in women. RORA…”
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Enhanced allele-specific PCR discrimination in SNP genotyping using 3′ locked nucleic acid (LNA) primers by Latorra, David, Campbell, Krista, Wolter, Andreas, Hurley, J. Michael

“…The specificity and reliability of locked nucleic acid (LNA) substitution at the 3′ position of allele‐specific PCR (AS‐PCR) primers for SNP detection was…”
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Microbiome alterations are associated with apolipoprotein E mutation in Octodon degus and humans with Alzheimer’s disease by Zampieri, Guido, Cabrol, Léa, Urra, Claudio, Castro-Nallar, Eduardo, Schwob, Guillaume, Cleary, David, Angione, Claudio, Deacon, Robert M.J., Hurley, Michael J., Cogram, Patricia

“…Gut microbiome dysbiosis is linked to many neurological disorders including Alzheimer’s disease (AD). A major risk factor for AD is polymorphism in the…”
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Genome Sequencing Variations in the Octodon degus , an Unconventional Natural Model of Aging and Alzheimer's Disease by Hurley, Michael J, Urra, Claudio, Garduno, B Maximiliano, Bruno, Agostino, Kimbell, Allison, Wilkinson, Brent, Marino-Buslje, Cristina, Ezquer, Marcelo, Ezquer, Fernando, Aburto, Pedro F, Poulin, Elie, Vasquez, Rodrigo A, Deacon, Robert, Avila, Ariel, Altimiras, Francisco, Whitney Vanderklish, Peter, Zampieri, Guido, Angione, Claudio, Constantino, Gabriele, Holmes, Todd C, Coba, Marcelo P, Xu, Xiangmin, Cogram, Patricia

“…The degu ( ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age…”
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Controlling the misuse of cobalt in horses by Ho, Emmie N. M., Chan, George H. M., Wan, Terence S. M., Curl, Peter, Riggs, Christopher M., Hurley, Michael J., Sykes, David

“…Cobalt is a well‐established inducer of hypoxia‐like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce…”
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Bile acids and neurological disease by Hurley, Michael J., Bates, Rachel, Macnaughtan, Jane, Schapira, Anthony H.V.

“…This review will focus on how bile acids are being used in clinical trials to treat neurological diseases due to their central involvement with the…”
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Design considerations and effects of LNA in PCR primers by Latorra, David, Arar, Khalil, Michael Hurley, J

“…The effects of comprehensive LNA substitution in PCR primers for amplification of human genomic DNA targets are presented in this report. Previous research…”
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Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice by Hurley, Michael J, Deacon, Robert M J, Chan, A W Edith, Baker, David, Selwood, David L, Cogram, Patricia

“…Fragile X syndrome is the most common inherited intellectual disability and mono-genetic cause of autism spectrum disorder. It is a neurodevelopmental…”
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The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases by Hurley, Michael J., Deacon, Robert M.J., Beyer, Katrin, Ioannou, Elena, Ibáñez, Agustin, Teeling, Jessica L., Cogram, Patricia

“…Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and…”
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Voltage-gated calcium channels and Parkinson's disease by Hurley, Michael J, Dexter, David T

“…A complex interaction of environmental, genetic and epigenetic factors combine with ageing to cause the most prevalent of movement disorders Parkinson's…”
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Preface. Omic Studies of Neurodegenerative Disease: Part A by Hurley, Michael J

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Sampling Almonds for Aflatoxin, Part I: Estimation of Uncertainty Associated with Sampling, Sample Preparation, and Analysis by Whitaker, T.B, Slate, A.B, Jacobs, M, Hurley, J.M, Giesbrecht, F.G

“…Domestic and international regulatory limits have been established for aflatoxin in almonds and other tree nuts. It is difficult to obtain an accurate and…”
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NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome by Deacon, Robert M. J., Glass, Larry, Snape, Mike, Hurley, Michael J., Altimiras, Francisco J., Biekofsky, Rodolfo R., Cogram, Patricia

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the…”
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Calcium CaV1 Channel Subtype mRNA Expression in Parkinson’s Disease Examined by In Situ Hybridization by Hurley, Michael J., Gentleman, Steve M., Dexter, David T.

“…The factors which make some neurons vulnerable to neurodegeneration in Parkinson’s disease while others remain resistant are not fully understood. Studies in…”
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α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an in vitro proof of concept study by Hurley, Michael J, Menozzi, Elisa, Koletsi, Sofia, Bates, Rachel, Gegg, Matthew E, Chau, Kai-Yin, Blottière, Hervé M, Macnaughtan, Jane, Schapira, Anthony H V

“…Abstract Caudo-rostral migration of pathological forms of α-synuclein from the gut to the brain is proposed as an early feature in Parkinson’s disease…”
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Multiplex allele-specific PCR with optimized locked nucleic acid primers by Latorra, David, Hopkins, Deborah, Campbell, Krista, Hurley, J Michael

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Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson’s Disease by Hurley, Michael J., Durrenberger, Pascal F., Gentleman, Steve M., Walls, Andrew F., Dexter, David T.

“…Neuroinflammation is thought to contribute to cell death in neurodegenerative disorders, but the factors involved in the inflammatory process are not…”
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