Search Results - "Hurley, James"

ESCRTs are everywhere by Hurley, James H

“…The ESCRT proteins are an ancient system that buds membranes and severs membrane necks from their inner face. Three “classical” functions of the ESCRTs have…”
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Molecular mechanism of multivesicular body biogenesis by ESCRT complexes by Hurley, James H, Wollert, Thomas

“…When internalized receptors and other cargo are destined for lysosomal degradation, they are ubiquitinated and sorted by the endosomal sorting complex required…”
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Mechanisms of Autophagy Initiation by Hurley, James H, Young, Lindsey N

“…Autophagy is the process of cellular self-eating by a double-membrane organelle, the autophagosome. A range of signaling processes converge on two protein…”
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Indirect (herd) effects of topical antibiotic prophylaxis and oral care versus non-antimicrobial methods increase mortality among ICU patients: realigning Cochrane review data to emulate a three-tier cluster randomised trial by Hurley, James

“…ObjectiveThis study aimed to estimate the direct effects to recipients and indirect (herd) effects to non-recipients of each of topical antibiotic prophylaxis…”
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The ESCRT complexes by Hurley, James H

“…The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0, -I, -II, -III, and Vps4-Vta1, and the ALIX homodimer. The ESCRT system is…”
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Selective digestive decontamination-Con by Hurley, James C.

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Autophagosome biogenesis comes out of the black box by Chang, Chunmei, Jensen, Liv E., Hurley, James H.

“…Macroautophagic clearance of cytosolic materials entails the initiation, growth and closure of autophagosomes. Cargo triggers the assembly of a web of cargo…”
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ESCRT complexes and the biogenesis of multivesicular bodies by Hurley, James H

“…Multivesicular bodies (MVBs) are crucial intermediates in the trafficking of ubiquitinated receptors and other cargo destined for lysosomes. The formation of…”
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Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection by Hurley, James B

“…The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O 2 , glucose, and other nutrients diffuse out of the choroid and then…”
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Structural equation modelling the impact of antimicrobials on the human microbiome. Colonization resistance versus colonization susceptibility as case studies by Hurley, James C

“…The impact of antimicrobials on the human microbiome and its relationship to human health are of great interest. How antimicrobial exposure might drive change…”
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Atomistic autophagy: the structures of cellular self-digestion by Hurley, James H, Schulman, Brenda A

“…Autophagy is directed by numerous distinct autophagy-related (Atg) proteins. These transmit starvation-induced signals to lipids and regulatory proteins and…”
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Rebound Inverts the Staphylococcus aureus Bacteremia Prevention Effect of Antibiotic Based Decontamination Interventions in ICU Cohorts with Prolonged Length of Stay by Hurley, James

“…Could rebound explain the paradoxical lack of prevention effect against blood stream infections (BSIs) with antibiotic-based decontamination intervention (BDI)…”
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How the Cluster-randomized Trial “Works” by Hurley, James C

“…Abstract Cluster-randomized trials (CRTs) are able to address research questions that randomized controlled trials (RCTs) of individual patients cannot answer…”
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Structure and function of the ULK1 complex in autophagy by Lin, Mary G, Hurley, James H

“…The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to downstream events in autophagy. Recent work suggests that the ULK1…”
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Staphylococcus aureus hitchhiking from colonization to bacteremia via Candida within ICU infection prevention studies: a proof of concept modelling by Hurley, James C.

“…Whether Candida within the patient microbiome drives the pathogenesis of Staphylococcus aureus bacteremia, described as microbial hitchhiking, cannot be…”
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Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy by Baskaran, Sulochanadevi, Ragusa, Michael J., Boura, Evzen, Hurley, James H.

“…Macroautophagy is essential to cell survival during starvation and proceeds by the growth of a double-membraned phagophore, which engulfs cytosol and other…”
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Visualizing and diagnosing spillover within randomized concurrent controlled trials through the application of diagnostic test assessment methods by Hurley, James C

“…Spillover of effect, whether positive or negative, from intervention to control group patients invalidates the Stable Unit Treatment Variable Assumption…”
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Structural equation modeling the "control of gut overgrowth" in the prevention of ICU-acquired Gram-negative infection by Hurley, James C

“…Conceptually, the "control of gut overgrowth" (COGO) is key in mediating prevention against infection with Gram-negative bacilli by topical antibiotic…”
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Selective digestive decontamination, a seemingly effective regimen with individual benefit or a flawed concept with population harm? by Hurley, James C

“…Abstract Selective digestive decontamination (SDD) regimens, variously constituted with topical antibiotic prophylaxis (TAP) and protocolized parenteral…”
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Membrane budding and scission by the ESCRT machinery: it's all in the neck by Hurley, James H, Hanson, Phyllis I

“…Key Points Endosomal sorting complexes required for transport (ESCRTs) are required for the lysosomal degradation of plasma membrane proteins, budding of most…”
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