Search Results - "Hurkmans, Karen"

Ranking the Susceptibility of Disulfide Bonds in Human IgG1 Antibodies by Reduction, Differential Alkylation, and LC−MS Analysis by Liu, Hongcheng, Chumsae, Chris, Gaza-Bulseco, Georgeen, Hurkmans, Karen, Radziejewski, Czeslaw H

“…One of the basic structural features of human IgG1 is the arrangement of the disulfide bond structure, 4 inter chain disulfide bonds in the hinge region and 12…”
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Effect of methionine oxidation of a recombinant monoclonal antibody on the binding affinity to protein A and protein G by Gaza-Bulseco, Georgeen, Faldu, Sagar, Hurkmans, Karen, Chumsae, Chris, Liu, Hongcheng

“…Oxidation of methionine (Met) residues is one of the most common protein degradation pathways. Two Met residues, Met256 and Met432, of a recombinant fully…”
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“High‐risk” host cell proteins (HCPs): A multi‐company collaborative view by Jones, Marisa, Palackal, Nisha, Wang, Fengqiang, Gaza‐Bulseco, Georgeen, Hurkmans, Karen, Zhao, Yiwei, Chitikila, Carmelata, Clavier, Severine, Liu, Suli, Menesale, Emily, Schonenbach, Nicole S., Sharma, Satish, Valax, Pascal, Waerner, Thomas, Zhang, Lei, Connolly, Trish

“…Host cell proteins (HCPs) are process‐related impurities that may copurify with biopharmaceutical drug products. Within this class of impurities there are some…”
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Effect of the conserved oligosaccharides of recombinant monoclonal antibodies on the separation by protein A and protein G chromatography by Gaza-Bulseco, Georgeen, Hickman, Keith, Sinicropi-Yao, Sara, Hurkmans, Karen, Chumsae, Chris, Liu, Hongcheng

“…Glycosylation of the conserved asparagine residue in CH2 domains of IgG molecules is an important post-translational modification. The presence of…”
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