Search Results - "Hurdayal, Ramona"

Interleukin-4 Receptor Alpha: From Innate to Adaptive Immunity in Murine Models of Cutaneous Leishmaniasis by Hurdayal, Ramona, Brombacher, Frank

“…The interleukin (IL)-4 receptor alpha (IL-4Rα), ubiquitously expressed on both innate and adaptive immune cells, controls the signaling of archetypal type 2…”
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Inflammatory Dendritic Cells, Regulated by IL-4 Receptor Alpha Signaling, Control Replication, and Dissemination of Leishmania major in Mice by Hurdayal, Ramona, Nieuwenhuizen, Natalie Eva, Khutlang, Rethabile, Brombacher, Frank

“…Leishmaniasis is a vector-borne disease caused by parasites. Macrophages are considered the primary parasite host cell, but dendritic cells (DCs) play a…”
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Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection by Roy, Sugata, Guler, Reto, Parihar, Suraj P, Schmeier, Sebastian, Kaczkowski, Bogumil, Nishimura, Hajime, Shin, Jay W, Negishi, Yutaka, Ozturk, Mumin, Hurdayal, Ramona, Kubosaki, Atsutaka, Kimura, Yasumasa, de Hoon, Michiel J L, Hayashizaki, Yoshihide, Brombacher, Frank, Suzuki, Harukazu

“…Basic leucine zipper transcription factor Batf2 is poorly described, whereas Batf and Batf3 have been shown to play essential roles in dendritic cell, T cell,…”
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IL-4 Mediated Resistance of BALB/c Mice to Visceral Leishmaniasis Is Independent of IL-4Rα Signaling via T Cells by McFarlane, Emma, Mokgethi, Thabang, Kaye, Paul M, Hurdayal, Ramona, Brombacher, Frank, Alexander, James, Carter, Katharine C

“…Previous studies infecting global IL-4Rα , IL-4 , and IL-13 mice on a BALB/c background with the visceralizing parasite have shown that the T helper 2…”
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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection by Hurdayal, Ramona, Nieuwenhuizen, Natalie E, Revaz-Breton, Mélanie, Smith, Liezel, Hoving, Jennifer C, Parihar, Suraj P, Reizis, Boris, Brombacher, Frank

“…In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses…”
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Interleukin-4 Responsive Dendritic Cells Are Dispensable to Host Resistance Against Leishmania mexicana Infection by Osero, Bernard Ong'ondo, Cele, Zama, Aruleba, Raphael Taiwo, Maine, Rebeng A, Ozturk, Mumin, Lutz, Manfred B, Brombacher, Frank, Hurdayal, Ramona

“…IL-4 and IL-13 cytokines have been associated with a non-healing phenotype in murine leishmaniasis in -infected BALB/c mice as demonstrated in IL-4 , IL-13 and…”
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Can We Harness Immune Responses to Improve Drug Treatment in Leishmaniasis? by Aruleba, Raphael Taiwo, Carter, Katharine C., Brombacher, Frank, Hurdayal, Ramona

“…Leishmaniasis is a vector-borne parasitic disease that has been neglected in priority for control and eradication of malaria, tuberculosis, and HIV/AIDS…”
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Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages by Nieuwenhuizen, Natalie E., PhD, Kirstein, Frank, PhD, Jayakumar, Jaisubash, MSc, Emedi, Babele, MSc, Hurdayal, Ramona, MSc, Horsnell, William G.C., PhD, Lopata, Andreas L., PhD, Brombacher, Frank, PhD

“…Background Markers of alternatively activated macrophages (AAMs) are upregulated in the lungs of asthmatic patients and in mice with allergic airway disease…”
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IL-4Rα Signaling in Keratinocytes and Early IL-4 Production Are Dispensable for Generating a Curative T Helper 1 Response in Leishmania major -Infected C57BL/6 Mice by Descatoire, Marc, Hurrell, Benjamin P, Govender, Melissa, Passelli, Katiuska, Martinez-Salazar, Berenice, Hurdayal, Ramona, Brombacher, Frank, Guler, Reto, Tacchini-Cottier, Fabienne

“…Experimental infection with the protozoan parasite has been extensively used to understand the mechanisms involved in T helper cell differentiation. Following…”
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Dendritic cell-mediated vaccination relies on interleukin-4 receptor signaling to avoid tissue damage after Leishmania major infection of BALB/c mice by Masic, Anita, Hurdayal, Ramona, Nieuwenhuizen, Natalie E, Brombacher, Frank, Moll, Heidrun

“…Prevention of tissue damages at the site of Leishmania major inoculation can be achieved if the BALB/c mice are systemically given L. major antigen…”
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Anti-peptide antibodies in the diagnosis of malaria by Dean Goldring, J P, Hurdayal, Ramona, Choveaux, David

“…Author information Affiliations 1. Ikechukwu Achilonu Biochemistry, University of KwaZulu-Natal, Pietermaritzburg, 3209, South Africa * J P Dean Goldring * ,…”
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The role of IL-4 and IL-13 in cutaneous Leishmaniasis by Hurdayal, Ramona, Brombacher, Frank

“…Highlights • We update on gene-deficient mouse models of cutaneous Leishmaniasis. • The global and cell-specific roles of IL-4 and IL-13 during disease are…”
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Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation by Parihar, Suraj P., Guler, Reto, Khutlang, Rethabile, Lang, Dirk M., Hurdayal, Ramona, Mhlanga, Musa M., Suzuki, Harukazu, Marais, A. David, Brombacher, Frank

“…Background. Statins are cholesterol-lowering drugs, targeting HMG-CoA reductase, thereby reducing the risk of coronary disorders and hypercholesterolemia…”
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IL-4–producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases by Hurdayal, Ramona, Ndlovu, Hlumani H., Revaz-Breton, Mélanie, Parihar, Suraj P., Nono, Justin Komguep, Govender, Melissa, Brombacher, Frank

“…Interleukin-4 (IL-4)–induced T helper (Th) 2 cells promote susceptibility to the protozoan parasite Leishmania major, while conferring immunity to the…”
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Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice by Parihar, Suraj P., Hartley, Mary-Anne, Hurdayal, Ramona, Guler, Reto, Brombacher, Frank

“…We recently demonstrated that statins mediate protection against intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes in mice. Here,…”
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Deletion of Interleukin-4 Receptor Alpha-Responsive Keratinocytes in BALB/c Mice Does Not Alter Susceptibility to Cutaneous Leishmaniasis by Govender, Melissa, Hurdayal, Ramona, Martinez-Salazar, Berenice, Gqada, Kaya, Pillay, Shandre, Gcanga, Lorna, Passelli, Katiuska, Nieuwenhuizen, Natalie E, Tacchini-Cottier, Fabienne, Guler, Reto, Brombacher, Frank

“…The skin microenvironment at the site of infection plays a role in the early events that determine protective T helper 1/type 1 immune responses during…”
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Unravelling the unsolved paradoxes of cytokine families in host resistance and susceptibility to Leishmania infection by Osero, Bernard Ong'ondo, Aruleba, Raphael Taiwo, Brombacher, Frank, Hurdayal, Ramona

“…•Cytokine communication in leishmaniasis begets host-resistance or susceptibility.•All cytokine families, except IFN, overlap as host-protectors or…”
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Plasmodium glyceraldehyde-3-phosphate dehydrogenase: A potential malaria diagnostic target by Krause, Robert G.E., Hurdayal, Ramona, Choveaux, David, Przyborski, Jude M., Coetzer, Theresa H.T., Goldring, J.P. Dean

“…Malaria rapid diagnostic tests (RDTs) are immunochromatographic tests detecting Plasmodial histidine-rich protein 2 (HRP2), lactate dehydrogenase (LDH) and…”
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Deletion of IL-4 receptor alpha on dendritic cells renders BALC/c mice hypersusceptible to Leishmania major infection by Hurdayal, Ramona, Nieuwenhuizen, Natalie E, Revaz-Breton, Melanie, Smith, Liezel, Hoving, Jennifer C, Parihar, Suraj P, Reizis, Boris, Brombacher, Frank

“…In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses…”
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Deletion of IL-4 Receptor Alpha on Dendritic Cells Renders BALB/c Mice Hypersusceptible to Leishmania major Infection: e1003699 by Hurdayal, Ramona, Nieuwenhuizen, Natalie E, Revaz-Breton, Mélanie, Smith, Liezel, Hoving, Jennifer C, Parihar, Suraj P, Reizis, Boris, Brombacher, Frank

“…In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses…”
Get full text