Search Results - "Hurd, YL"

Molecular alterations in the neostriatum of human cocaine addicts by Hurd, Y L, Herkenham, M

“…Molecular changes in the neostriatum of human subjects who died with a history of cocaine abuse were revealed in discrete cell populations by means of the…”
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Neuronal substrates and functional consequences of prenatal cannabis exposure by Calvigioni, Daniela, Hurd, Yasmin L., Harkany, Tibor, Keimpema, Erik

“…Cannabis remains one of the world’s most widely used substance of abuse amongst pregnant women. Trends of the last 50 years show an increase in popularity in…”
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Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage by Hurd, Yasmin L., Yoon, Michelle, Manini, Alex F., Hernandez, Stephanie, Olmedo, Ruben, Ostman, Maria, Jutras-Aswad, Didier

“…Multiple cannabinoids derived from the marijuana plant have potential therapeutic benefits but most have not been well investigated, despite the widespread…”
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Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring by DiNieri, Jennifer A, Wang, Xinyu, Szutorisz, Henrietta, Spano, Sabrina M, Kaur, Jasbir, Casaccia, Patrizia, Dow-Edwards, Diana, Hurd, Yasmin L

“…Background Prenatal cannabis exposure has been linked to addiction vulnerability, but the neurobiology underlying this risk is unknown. Methods Striatal…”
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Neurobiological consequences of maternal cannabis on human fetal development and its neuropsychiatric outcome by Jutras-Aswad, Didier, DiNieri, Jennifer A., Harkany, Tibor, Hurd, Yasmin L.

“…Despite the high prevalence of marijuana use among pregnant women and adolescents, the impact of cannabis on the developing brain is still not well understood…”
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Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning by Mulder, Jan, Aguado, Tania, Keimpema, Erik, Barabás, Klaudia, Ballester Rosado, Carlos J, Nguyen, Laurent, Monory, Krisztina, Marsicano, Giovanni, Di Marzo, Vincenzo, Hurd, Yasmin L, Guillemot, Francois, Mackie, Ken, Lutz, Beat, Guzmán, Manuel, Lu, Hui-Chen, Galve-Roperh, Ismael, Harkany, Tibor

“…Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing…”
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Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling by Alpár, Alán, Tortoriello, Giuseppe, Calvigioni, Daniela, Niphakis, Micah J., Milenkovic, Ivan, Bakker, Joanne, Cameron, Gary A., Hanics, János, Morris, Claudia V., Fuzik, János, Kovacs, Gabor G., Cravatt, Benjamin F., Parnavelas, John G., Andrews, William D., Hurd, Yasmin L., Keimpema, Erik, Harkany, Tibor

“…Local environmental cues are indispensable for axonal growth and guidance during brain circuit formation. Here, we combine genetic and pharmacological tools,…”
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Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons by Mazei-Robison, Michelle S., Koo, Ja Wook, Friedman, Allyson K., Lansink, Carien S., Robison, Alfred J., Vinish, Monika, Krishnan, Vaishnav, Kim, Seyun, Siuta, Michael A., Galli, Aurelio, Niswender, Kevin D., Appasani, Raghu, Horvath, Monika C., Neve, Rachel L., Worley, Paul F., Snyder, Solomon H., Hurd, Yasmin L., Cheer, Joseph F., Han, Ming-Hu, Russo, Scott J., Nestler, Eric J.

“…While the abuse of opiate drugs continues to rise, the neuroadaptations that occur with long-term drug exposure remain poorly understood. We describe here a…”
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Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects by Ellgren, M, Artmann, A, Tkalych, O, Gupta, A, Hansen, H.S, Hansen, S.H, Devi, L.A, Hurd, Y.L

“…Abstract Adolescence is a critical phase of active brain development often characterized by the initiation of marijuana ( Cannabis sativa ) use. Limited…”
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Estrogen Receptor Gene Expression in Relation to Neuropsychiatric Disorders by ÖSTLUND, HANNA, KELLER, EVA, HURD, YASMIN L.

“…: Compelling evidence now exists for estrogen's involvement in the regulation of mood and cognitive functions. Serum estrogen levels have been shown to play an…”
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Endocannabinoids Regulate Interneuron Migration and Morphogenesis by Transactivating the TrkB Receptor by Paul Berghuis, Marton B. Dobszay, Xinyu Wang, Sabrina Spano, Fernanda Ledda, Kyle M. Sousa, Gunnar Schulte, Ernfors, Patrik, Mackie, Ken, Gustavo Paratcha, Yasmin L. Hurd, Tibor Harkany

“…In utero exposure to$\Delta^9-tetrahydrocannabinol$($\Delta^9-THC$, the active component from marijuana, induces cognitive deficits enduring into adulthood…”
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Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression by Anderson, Sarah Ann R, Michaelides, Michael, Zarnegar, Parisa, Ren, Yanhua, Fagergren, Pernilla, Thanos, Panayotis K, Wang, Gene-Jack, Bannon, Michael, Neumaier, John F, Keller, Eva, Volkow, Nora D, Hurd, Yasmin L

“…Negative affect is critical for conferring vulnerability to opiate addiction as reflected by the high comorbidity of opiate abuse with major depressive…”
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Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels by Jacobs, M M, Ökvist, A, Horvath, M, Keller, E, Bannon, M J, Morgello, S, Hurd, Y L

“…Opioid drugs are highly addictive and their abuse has a strong genetic load. Dopamine–glutamate interactions are hypothesized to be important for regulating…”
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In utero marijuana exposure associated with abnormal amygdala dopamine D 2 gene expression in the human fetus by Wang, Xinyu, Dow-Edwards, Diana, Anderson, Virginia, Minkoff, Howard, Hurd, Yasmin L.

“…Marijuana (Cannabis sativa) is the illicit drug most used by pregnant women, and behavioral and cognitive impairments have been documented in cannabis-exposed…”
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Subjects with major depression or bipolar disorder show reduction of prodynorphin mRNA expression in discrete nuclei of the amygdaloid complex by Hurd, Y L

“…The dynorphin system has been associated with the regulation of mood. The expression of the prodynorphin mRNA was currently studied in the amygdaloid complex,…”
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Opioid neuropeptide genotypes in relation to heroin abuse: Dopamine tone contributes to reversed mesolimbic proenkephalin expression by Nikoshkov, Andrej, Drakenberg, Katarina, Wang, Xinyu, Horvath, Monika Cs, Keller, Eva, Hurd, Yasmin L

“…Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms…”
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Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders by Osterlund, M K, Hurd, Y L

“…The steroid hormone estrogen influences brain function and neuropsychiatric disorders, but neuroanatomical information about the estrogen receptors (ERs) are…”
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Dysregulated Postsynaptic Density and Endocytic Zone in the Amygdala of Human Heroin and Cocaine Abusers by Ökvist, Anna, Fagergren, Pernilla, Whittard, John, Garcia-Osta, Ana, Drakenberg, Katarina, Horvath, Monika Cs, Schmidt, Carl J, Keller, Eva, Bannon, Michael J, Hurd, Yasmin L

“…Background Glutamatergic transmission in the amygdala is hypothesized as an important mediator of stimulus-reward associations contributing to drug-seeking…”
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Adolescent Cannabis Exposure Alters Opiate Intake and Opioid Limbic Neuronal Populations in Adult Rats by ELLGREN, Maria, SPANO, Sabrina M, HURD, Yasmin L

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Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling by Keimpema, Erik, Alpár, Alán, Howell, Fiona, Malenczyk, Katarzyna, Hobbs, Carl, Hurd, Yasmin L., Watanabe, Masahiko, Sakimura, Kenji, Kano, Masanobu, Doherty, Patrick, Harkany, Tibor

“…Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of…”
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