Analytical Performance of Polymer-Based Microfluidic Devices Fabricated By Computer Numerical Controlled Machining

A study comparing the electrophoretic separation performance attainable from microchips molded by masters fabricated using conventional CNC machining techniques with commercial microchips, wire imprinted microchips, and microchips from LIGA molding devices is presented. An electrophoresis-based dete...

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Bibliographic Details
Published in:	Analytical chemistry (Washington) Vol. 78; no. 3; pp. 936 - 941
Main Authors:	Mecomber, Justin S, Stalcup, Apryll M, Hurd, Doug, Halsall, H. Brian, Heineman, William R, Seliskar, Carl J, Wehmeyer, Kenneth R, Limbach, Patrick A
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 01-02-2006
Subjects:	Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Computer-Aided Design Exact sciences and technology Image Processing, Computer-Assisted - instrumentation Image Processing, Computer-Assisted - methods Methods Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Micromachining Microprocessors Other chromatographic methods Polymers - chemistry Sensitivity and Specificity Time Factors Performance evaluation Fluorescence detector Imprinting Electrophoresis Polymer System on a chip Microfluidics Mold
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Summary:	A study comparing the electrophoretic separation performance attainable from microchips molded by masters fabricated using conventional CNC machining techniques with commercial microchips, wire imprinted microchips, and microchips from LIGA molding devices is presented. An electrophoresis-based detection system using fluorescence microscopy was used to determine the analytical utility of these microchips. The separation performance of CNC microchips was comparable to commercially available microchips as well as those fabricated from LIGA masters. The important feature of the CNC machined masters is that they have rapid design-to-device times using routinely available machining tools. This low-cost prototyping approach provides a new entry point for researchers interested in thermoplastic microchips and can accelerate the development of polymer-based lab-on-a-chip devices.
Bibliography:	ark:/67375/TPS-7SD73DKR-0 istex:F817E6A23A8BB2A20FC37ED1949C73616207A10A ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac051523y