A PROSPECTIVE CLINICAL TRIAL COMPARING METRIZAMIDE AND IOHEXOL FOR EQUINE MYELOGRAPHY

A prospective clinical trial comparing adverse postmyelographic effects and myelographic quality of metrizamide and iohexol was conducted. Using a predetermined, randomized assignment, 24 horses exhibiting neurologic signs were administered either metrizamide (180 mgl/ml) or iohexol (180 mgl/ml) via...

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Bibliographic Details
Published in:	Veterinary radiology & ultrasound Vol. 39; no. 2; pp. 106 - 109
Main Authors:	Widmer, William R., Blevins, William E., Jakovljevic, Samuel, Levy, Michel, Teclaw, Robert F., Han, Connie M., Hurd, Cheryl D.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-03-1998
Subjects:	adverse effects Anesthesia Recovery Period Anesthesia, Inhalation - veterinary Anesthesia, Intravenous - veterinary Animals Contrast Media - administration & dosage Contrast Media - adverse effects Double-Blind Method equine Female Fever - chemically induced Fever - veterinary Horse Diseases - chemically induced Horse Diseases - diagnostic imaging Horses - classification iohexol Iohexol - administration & dosage Iohexol - adverse effects Male metrizamide Metrizamide - administration & dosage Metrizamide - adverse effects myelographic quality myelography Myelography - methods Myelography - veterinary Prospective Studies Punctures - veterinary Radiographic Image Enhancement Random Allocation Safety Seizures - chemically induced Seizures - veterinary Spinal Cord Diseases - diagnostic imaging Spinal Cord Diseases - veterinary
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Summary:	A prospective clinical trial comparing adverse postmyelographic effects and myelographic quality of metrizamide and iohexol was conducted. Using a predetermined, randomized assignment, 24 horses exhibiting neurologic signs were administered either metrizamide (180 mgl/ml) or iohexol (180 mgl/ml) via cerebellomedullary puncture. Each horse was evaluated postmyelographically for adverse effects. Myelographic quality was assessed by a numerical scoring method. Adverse effects were observed more frequently with metrizamide (21) compared with iohexol (6) myelography (p < 0.05). Seizures, intensification of preexisting neurologic signs and prolonged anesthetic recovery were the most common complications after myelography. There was no difference in myelographic quality (p > 0.05). We conclude that iohexol is safer than metrizamide for equine myelography and that quality myelograms can be obtained with either contrast medium.
Bibliography:	istex:25E8B8CF311AE62D17EA9FDEB97DDE64B1280E2A ark:/67375/WNG-LBFQDS37-G ArticleID:VRU106 The contrast media used in this study were provided by Nycomed, Inc., 101 Carnegie Center, Princeton, NJ.
ISSN:	1058-8183 1740-8261
DOI:	10.1111/j.1740-8261.1998.tb01974.x