Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat

Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired atten...

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Bibliographic Details
Published in:	Marine drugs Vol. 17; no. 9; p. 501
Main Authors:	Kim, Ran, Hur, Daeun, Kim, Hyoung Kyu, Han, Jin, Mishchenko, Natalia P, Fedoreyev, Sergey A, Stonik, Valentin A, Chang, Woochul
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 28-08-2019 MDPI
Subjects:	Animals Antioxidants Antioxidants - administration & dosage Apoptosis Apoptosis - drug effects Behavior Behavior Observation Techniques Behavior, Animal - drug effects Brain Brain - blood supply Brain - cytology Brain - drug effects Brain injury brain ischemic stroke Brain-derived neurotrophic factor Carotid arteries Carotid artery Cell death Cell growth Cell survival Cell Survival - drug effects Cell viability Cerebral blood flow Disease Disease Models, Animal echinochrome A Edema Free radicals Health services Humans Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - etiology Injuries Ischemia Kinases Laboratory animals Male Marine invertebrates Medical technology Middle Cerebral Artery - surgery Naphthoquinones - administration & dosage Neuroprotective Agents - administration & dosage Occlusion Oxidative stress Oxidative Stress - drug effects Physiological effects Physiology Rats Recovery Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - etiology Restoration Sea urchins Sea Urchins - chemistry Survival Swimming Treatment Outcome Veins & arteries echinochrome A cell survival brain ischemic stroke
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Summary:	Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies. Due to its antioxidant activity, Echinochrome A (Ech A), a natural compound found in sea urchins, has acquired attention as an alternative clinical trial source for the treatment of ischemic stroke. The current study demonstrates considerable potential of Ech A as a medication for cerebral ischemic injury. To confirm the effects of Ech A on the recovery of the injured region and behavioral decline, Ech A was administered through the external carotid artery in a rat middle cerebral artery occlusion model after reperfusion. The expression level of cell viability-related factors was also examined to confirm the mechanism of brain physiological restoration. Based on the results obtained, we propose that Ech A ameliorates the physiological deterioration by its antioxidant effect which plays a protective role against cell death, subsequent to post cerebral ischemic stroke.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md17090501