Search Results - "Hupe, D J"

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily by Dhanaraj, V, Ye, Q-Z, Johnson, LL, Hupe, DJ, Ortwine, DF, Dunbar,Jr, JB, Rubin, JR, Pavlovsky, A, Humblet, C, Blundell, TL

“…Background: Stromelysin belongs to a family of zinc-dependent endopeptidases referred to as matrix metalloproteinases (MMPs, matrixins) because of their…”
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Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structure elucidation and biological activity by Pairet, L, Wrigley, S K, Chetland, I, Reynolds, E E, Hayes, M A, Holloway, J, Ainsworth, A M, Katzer, W, Cheng, X M, Hupe, D J

“…A series of azaphilones produced by Penicillium sclerotiorum (Xenova culture collection number X11853) active in assays for the detection of antagonists of the…”
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Solution structure of the catalytic domain of human stromelysin complexed with a hydrophobic inhibitor by Van Doren, Steven R., Kurochkin, Alexander V., Hu, Weidong, Ye, Qi‐Zhuang, Johnson, Linda L., Hupe, Donald J., Zuiderweg, ERIK R.P.

“…Stromelysin, a representative matrix metalloproteinase and target of drug development efforts, plays a prominent role in the pathological proteolysis…”
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The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582 by HUPE, D. J, BOLTZ, R, COHEN, C. J, FELIX, J, HAM, E, MILLER, D, SODERMAN, D, VAN SKIVER, D

“…L-651,582, 5-amino-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4- carboxamide, an antiproliferative and antiparasitic agent previously shown to…”
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Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli by Ye, Qi Zhuang, Johnson, Linda L, Hupe, Donald J, Baragi, Vijaykumar

“…Human stromelysin is a member of the matrix metalloproteinase family involved in connective tissue degradation. The stromelysin catalytic domain (SCD) lacking…”
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Matrix metalloproteinases by Johnson, Linda L, Dyer, Richard, Hupe, Donald J

“…Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during…”
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IMP dehydrogenase from the intracellular parasitic protozoan Eimeria tenella and its inhibition by mycophenolic acid by Hupe, D J, Azzolina, B A, Behrens, N D

“…Mycophenolic acid (MA) was demonstrated to be an effective inhibitor of the growth of the intracellular parasitic protozoan Eimeria tenella in tissue culture…”
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Nonlinear structure-reactivity correlations. Acyl transfer between sulfur and oxygen nucleophiles by Hupe, D. J, Jencks, W. P

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Assignments for the main-chain nuclear magnetic resonances and delineation of the secondary structure of the catalytic domain of human stromelysin-1 as obtained from triple-resonance 3D NMR experiments by Van Doren, Steven R., Kurochkin, Alexander V., Ye, Qi Zhuang, Johnson, Linda L., Hupe, Donald J., Zuiderweg, Erik R. P.

“…We report the NMR assignments for the main-chain 13C, 15N, and 1H resonances (1HN, 1H alpha, 15N alpha, 13C alpha, 13CO) for the 19.5-kDa catalytic domain of…”
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L-651,582 inhibition of intracellular parasitic protozoal growth correlates with host-cell directed effects by Hupe, D J, Pfefferkorn, E R, Behrens, N D, Peters, K

“…L-651,582 (5-amino-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4- carboxamide), which is active in vivo against coccidiosis caused by the…”
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Novel drimane sesquiterpene esters from Aspergillus ustus var. pseudodeflectus with endothelin receptor binding activity by Hayes, M A, Wrigley, S K, Chetland, I, Reynolds, E E, Ainsworth, A M, Renno, D V, Latif, M A, Cheng, X M, Hupe, D J, Charlton, P, Doherty, A M

“…A series of novel drimane sesquiterpene esters (1-6) was isolated from fermentations of Aspergillus ustus var. pseudodeflectus and their structures elucidated…”
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A Rationalization of the Acidic pH Dependence for Stromelysin-1 (Matrix Metalloproteinase-3) Catalysis and Inhibition by Johnson, Linda L., Pavlovsky, Alexander G., Johnson, Adam R., Janowicz, Jeffrey A., Man, Chiu-Fai, Ortwine, Daniel F., Purchase, Claude F., White, Andrew D., Hupe, Donald J.

“…The pH dependence of matrix metalloproteinase (MMP) catalysis is described by a broad bell-shaped curve, indicating the involvement of two unspecified…”
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A method for assaying orotate phosphoribosyltransferase and measuring phosphoribosylpyrophosphate by Hupe, D J, Behrens, N D

“…An orotate phosphoribosyltransferase, OPRTase, assay method which relies upon binding reactant [3H]orotic acid and product [3H]orotidine-5'-monophosphate to…”
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Structure-reactivity correlations for the thiol-disulfide interchange reaction by Wilson, Janet M, Bayer, Robert J, Hupe, D. J

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Pyridinone Derivatives: Specific Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors with Antiviral Activity by Goldman, Mark E., Nunberg, Jack H., O'Brien, Julie A., Quintero, Julio C., Schleif, William A., Freund, Kurt F., Gaul, S. Lee, Saari, Walfred S., Wai, John S., Hoffman, Jacob M., Anderson, Paul S., Hupe, Donald J., Emini, Emilio A., Stern, Andrew M.

“…Derivatives of pyridinones were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity and prevent the spread of…”
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A spectrophotometric method for studying the rates of reaction of disulfides with protein thiol groups applied to bovine serum albumin by Wilson, Janet M, Wu, Dorothy, Motiu-DeGrood, Rossana, Hupe, D. J

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On the magnitude of primary isotope effects for proton abstraction from carbon by Hupe, D. J., Pohl, E. R.

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Effect of charged substituents on rates of the thiol-disulfide interchange reaction by Hupe, D. J, Wu, Dorothy

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The effect of solvation on Broensted .beta. values for proton transfer reactions by Hupe, D. J, Wu, Dorothy

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An inhibitor for aldolase by Wilde, Joyce, Hunt, William, Hupe, D. J

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