Search Results - "Huotari, Marko"

Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice by Huotari, Marko, Santha, Miklos, Lucas, Louis R, Karayiorgou, Maria, Gogos, Joseph A, Männistö, Pekka T

“…Two different uptake processes terminate the synaptic action of released catecholamines in brain: the high-affinity uptake to presynaptic nerve terminals…”
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Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice by Huotari, Marko, Gogos, Joseph A., Karayiorgou, Maria, Koponen, Olli, Forsberg, Markus, Raasmaja, Atso, Hyttinen, Juha, Männistö, Pekka T.

“…Catechol‐O‐methyltransferase (COMT) catalyses the O‐methylation of compounds having a catechol structure and its main function involves the elimination of…”
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d-Amphetamine responses in catechol-O-methyltransferase (COMT) disrupted mice by HUOTARI, Marko, GARCIA-HORSMAN, J. Arturo, KARAYIORGOU, Maria, GOGOS, Joseph A, MÄNNISTÖ, Pekka T

“…We have earlier found that 1). COMT inhibitors did not enhance amphetamine-induced dopamine efflux into striatal extracellular, that 2). they did not increase…”
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Microdialysis Studies on the Action of Tolcapone on Pharmacologically‐Elevated Extracellular Dopamine Levels in Conscious Rats by Huotari, Marko, Gainetdinov, Raul, Männistö, Pekka T.

“…To elucidate the importance of catechol‐O‐methyltransferase, we performed striatal microdialysis studies in conscious rats given tolcapone, an inhibitor of…”
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Modulation of histamine H3 receptors in the brain of 6-hydroxydopamine-lesioned rats by Anichtchik, Oleg V., Huotari, Marko, Peitsaro, Nina, Haycock, John W., Männistö, Pekka T., Panula, Pertti

“…Parkinson's disease is a major neurological disorder that primarily affects the nigral dopaminergic cells. Nigral histamine innervation is altered in human…”
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Modulation of histamine H 3 receptors in the brain of 6‐hydroxydopamine‐lesioned rats by Anichtchik, Oleg V., Huotari, Marko, Peitsaro, Nina, Haycock, John W., Männistö, Pekka T., Panula, Pertti

“…Parkinson's disease is a major neurological disorder that primarily affects the nigral dopaminergic cells. Nigral histamine innervation is altered in human…”
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The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration by Forsberg, Markus M., Huotari, Marko, Savolainen, Jouko, Männistö, Pekka T.

“…Aqueous solubility, apparent partition coefficient (log P app) and catechol- O-methyltransferase (COMT, EC 2.1.1.6) inhibiting potency of entacapone and…”
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Resistance to salt-induced hypertension in catechol-O-methyltransferase-gene-disrupted mice by Helkamaa, Teemu, Männistö, Pekka T, Rauhala, Pekka, Cheng, Zhong Jian, Finckenberg, Piet, Huotari, Marko, Gogos, Joseph A, Karayiorgou, Maria, Mervaala, Eero MA

“…BACKGROUNDPrevious studies have indicated that catechol-O-methyltransferase (COMT) can modulate renal dopaminergic tone. OBJECTIVETo test the hypothesis that…”
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Tissue histopathology, clinical chemistry and behaviour of adult comt-gene-disrupted mice by Haasio, Kristiina, Huotari, Marko, Nissinen, Erkki, Männistö, Pekka T.

“…Catechol‐O‐methyltransferase (COMT) enzyme is a widely distributed enzyme that catalyses O‐methylation of catecholamines and other compounds having a catechol…”
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Serotonergic Activation after 2‐Week Intrastriatal Infusion of l‐Dopa and Slow Recovery of Circling in Rats with Unilateral Nigral Lesions by Kääriäinen, Tiina M., García‐Horsman, J. Arturo, Piltonen, Marjo, Huotari, Marko, Männistö, Pekka T.

“…:   A unilateral 6‐hydroxydopamine (6‐OHDA)‐lesioned rat model of Parkinson's disease was used to determine an effective dose to abolish circling behaviour of…”
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Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters by Airaksinen, Anu J, Huotari, Marko, Shvetsov, Alexander, Vainiotalo, Pirjo, Männisto, Pekka T, Tuomisto, Leena, Bergström, Kim A, Vepsäläinen, Jouko

“…6beta/7beta-Methyl-2-methoxycarbonyltropinones (3a, 3b) were synthesized and used as starting materials in the synthesis of…”
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Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system by KOKS, Sulev, VOLKE, Vallo, VASAR, Eero, VERAKSITS, Alar, RÜNKORG, Kertu, SILLAT, Tarvo, ABRAMOV, Urho, BOURIN, Michel, HUOTARI, Marko, MÄNNISTÖ, Pekka T, MATSUI, Toshimistu

“…Cholecystokinin (CCK) has been shown to coexist and interact with dopamine in the regulation of behaviour. Two different CCK receptors (CCK1 and CCK2) have an…”
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Modulation of histamine H(3) receptors in the brain of 6-hydroxydopamine-lesioned rats by Anichtchik, Oleg V, Huotari, Marko, Peitsaro, Nina, Haycock, John W

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Synthesis and biological evaluation of 6/7- exo-methyl-3β-(4-iodo)phenyltropane-2β-carboxylic acid methyl esters by Airaksinen, Anu J., Huotari, Marko, Shvetsov, Alexander, Vainiotalo, Pirjo, Männisto, Pekka T., Tuomisto, Leena, Bergström, Kim A., Vepsäläinen, Jouko

“…6β/7β-Methyl-2-methoxycarbonyltropinones ( 3a, 3b) were synthesized and used as starting materials in the synthesis of…”
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No change of brain extracellular catecholamine levels after acute catechol- O-methyltransferase inhibition: a microdialysis study in anaesthetized rats by Li, Ying-Hua, Wirth, Thomas, Huotari, Marko, Laitinen, Kirsti, MacDonald, Ewen, Männistö, Pekka T

“…Catechol- O-methyltransferase inhibitors have been newly introduced as adjunct drugs to the levodopa/dopa decarboxylase inhibitor therapy in Parkinson's…”
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Modulation of histamine H sub(3) receptors in the brain of 6-hydroxydopamine-lesioned rats by Anichtchik, Oleg V, Huotari, Marko, Peitsaro, Nina, Haycock, John W, Maennisto, Pekka T, Panula, Pertti

“…Parkinson's disease is a major neurological disorder that primarily affects the nigral dopaminergic cells. Nigral histamine innervation is altered in human…”
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Cholecystokinin 2 receptor-deficient mice display altered function of brain dopaminergic system by Kõks, Sulev, Volke, Vallo, Veraksits, Alar, Rünkorg, Kertu, Sillat, Tarvo, Abramov, Urho, Bourin, Michel, Huotari, Marko, Männistö, Pekka, Matsui, Toshimistu, Vasar, Eero

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Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures by Lampela, Pasi, Huotari, Marko, Harjula, Anu, Oinonen, Lasse, Ustav, Mart, Ylä-Herttuala, Seppo, Männistö, Pekka T., Raasmaja, Atso

“…Bovine papilloma virus type-1 (BPV-1)-based expression plasmids TkBPVTH and CGalBPVTH encoding the rat tyrosine hydroxylase (TH) enzyme have been designed for…”
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