Search Results - "Huo, Zhiguang"

Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis by Huo, Zhiguang, Yu, Lei, Yang, Jingyun, Zhu, Yun, Bennett, David A., Zhao, Jinying

“…The development of Alzheimer's dementia (AD) accompanies both central and peripheral metabolic disturbance, but the metabolic basis underlying AD and metabolic…”
Get full text

Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach by Cahill, Kelly M., Huo, Zhiguang, Tseng, George C., Logan, Ryan W., Seney, Marianne L.

“…Recent advances in large-scale gene expression profiling necessitate concurrent development of biostatistical approaches to reveal meaningful biological…”
Get full text

Transcriptome alterations in prefrontal pyramidal cells distinguish schizophrenia from bipolar and major depressive disorders by Arion, Dominique, Huo, Zhiguang, Enwright, John F, Corradi, John P, Tseng, George, Lewis, David A

“…Abstract Background Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in…”
Get full text

Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia by Seney, Marianne L., Cahill, Kelly, Enwright, John F., Logan, Ryan W., Huo, Zhiguang, Zong, Wei, Tseng, George, McClung, Colleen A.

“…Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here we identify diurnal rhythms in gene expression in the human…”
Get full text

Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies by He, Yonghan, Khan, Sajid, Huo, Zhiguang, Lv, Dongwen, Zhang, Xuan, Liu, Xingui, Yuan, Yaxia, Hromas, Robert, Xu, Mingjiang, Zheng, Guangrong, Zhou, Daohong

“…Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of…”
Get full text

ESR1 ChIP-Seq Identifies Distinct Ligand-Free ESR1 Genomic Binding Sites in Human Hepatocytes and Liver Tissue by Collins, Joseph M, Huo, Zhiguang, Wang, Danxin

“…The estrogen receptor alpha (ESR1) is an important gene transcriptional regulator, known to mediate the effects of estrogen. Canonically, ESR1 is activated by…”
Get full text

Comprehensive evaluation of fusion transcript detection algorithms and a meta-caller to combine top performing methods in paired-end RNA-seq data by Liu, Silvia, Tsai, Wei-Hsiang, Ding, Ying, Chen, Rui, Fang, Zhou, Huo, Zhiguang, Kim, SungHwan, Ma, Tianzhou, Chang, Ting-Yu, Priedigkeit, Nolan Michael, Lee, Adrian V, Luo, Jianhua, Wang, Hsei-Wei, Chung, I-Fang, Tseng, George C

“…Fusion transcripts are formed by either fusion genes (DNA level) or trans-splicing events (RNA level). They have been recognized as a promising tool for…”
Get full text

An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection by XINGBIN WANG, KANG, Dongwan D, KAMINSKI, Naftali, SIBILLE, Etienne, YAN LIN, JIA LI, TSENG, George C, KUI SHEN, CHI SONG, SHUYA LU, CHANG, Lun-Ching, LIAO, Serena G, ZHIGUANG HUO, SHAOWU TANG, YING DING

“…With the rapid advances and prevalence of high-throughput genomic technologies, integrating information of multiple relevant genomic studies has brought new…”
Get full text

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1 by Shen, Yang, Endale, Mehari, Wang, Wei, Morris, Andrew R, Francey, Lauren J, Harold, Rachel L, Hammers, David W, Huo, Zhiguang, Partch, Carrie L, Hogenesch, John B, Wu, Zhao-Hui, Liu, Andrew C

“…In mammals, the circadian clock coordinates cell physiological processes including inflammation. Recent studies suggested a crosstalk between these two…”
Get full text

Defining the age-dependent and tissue-specific circadian transcriptome in male mice by Wolff, Christopher A., Gutierrez-Monreal, Miguel A., Meng, Lingsong, Zhang, Xiping, Douma, Lauren G., Costello, Hannah M., Douglas, Collin M., Ebrahimi, Elnaz, Pham, Ann, Oliveira, Aline C., Fu, Chunhua, Nguyen, Amy, Alava, Bryan R., Hesketh, Stuart J., Morris, Andrew R., Endale, Mehari M., Crislip, G. Ryan, Cheng, Kit-yan, Schroder, Elizabeth A., Delisle, Brian P., Bryant, Andrew J., Gumz, Michelle L., Huo, Zhiguang, Liu, Andrew C., Esser, Karyn A.

“…Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated…”
Get full text

Kava as a Clinical Nutrient: Promises and Challenges by Bian, Tengfei, Corral, Pedro, Wang, Yuzhi, Botello, Jordy, Kingston, Rick, Daniels, Tyler, Salloum, Ramzi G, Johnston, Edward, Huo, Zhiguang, Lu, Junxuan, Liu, Andrew C, Xing, Chengguo

“…Kava beverages are typically prepared from the root of Piper methysticum. They have been consumed among Pacific Islanders for centuries. Kava extract…”
Get full text

Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults by Cruz-Almeida, Yenisel, Sinha, Puja, Rani, Asha, Huo, Zhiguang, Fillingim, Roger B, Foster, Thomas

“…Gerontological research reveals considerable interindividual variability in aging phenotypes, which has motivated research efforts to identify “aging…”
Get full text

Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2 by Logan, Ryan W., Ozburn, Angela R., Arey, Rachel N., Ketchesin, Kyle D., Winquist, Alicia, Crain, Andrew, Tobe, Brian T. D., Becker-Krail, Darius, Jarpe, Matthew B., Xue, Xiangning, Zong, Wei, Huo, Zhiguang, Parekh, Puja K., Zhu, Xiyu, Fitzgerald, Ethan, Zhang, Hui, Oliver-Smith, Jeffrey, DePoy, Lauren M., Hildebrand, Mariah A., Snyder, Evan Y., Tseng, George C., McClung, Colleen A.

“…Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we…”
Get full text

Opportunities and Challenges of Kava in Lung Cancer Prevention by Freeman, Breanne, Mamallapalli, Jessica, Bian, Tengfei, Ballas, Kayleigh, Lynch, Allison, Scala, Alexander, Huo, Zhiguang, Fredenburg, Kristianna M, Bruijnzeel, Adriaan W, Baglole, Carolyn J, Lu, Junxuan, Salloum, Ramzi G, Malaty, John, Xing, Chengguo

“…Lung cancer is the leading cause of cancer-related deaths due to its high incidence, late diagnosis, and limited success in clinical treatment. Prevention…”
Get full text

Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain by Peterson, Jessica A., Strath, Larissa J., Nodarse, Chavier Laffitte, Rani, Asha, Huo, Zhiguang, Meng, Lingsong, Yoder, Sean, Cole, James H., Foster, Thomas C., Fillingim, Roger B., Cruz-Almeida, Yenisel

“…Chronic musculoskeletal pain is a health burden that may accelerate the aging process. Accelerated brain aging and epigenetic aging have separately been…”
Get full text

DAXX drives de novo lipogenesis and contributes to tumorigenesis by Mahmud, Iqbal, Tian, Guimei, Wang, Jia, Hutchinson, Tarun E., Kim, Brandon J., Awasthee, Nikee, Hale, Seth, Meng, Chengcheng, Moore, Allison, Zhao, Liming, Lewis, Jessica E., Waddell, Aaron, Wu, Shangtao, Steger, Julia M., Lydon, McKenzie L., Chait, Aaron, Zhao, Lisa Y., Ding, Haocheng, Li, Jian-Liang, Purayil, Hamsa Thayele, Huo, Zhiguang, Daaka, Yehia, Garrett, Timothy J., Liao, Daiqing

“…Cancer cells exhibit elevated lipid synthesis. In breast and other cancer types, genes involved in lipid production are highly upregulated, but the mechanisms…”
Get full text

Enrichment of genomic pathways based on differential DNA methylation profiles associated with chronic musculoskeletal pain in older adults: An exploratory study by Montesino-Goicolea, Soamy, Sinha, Puja, Huo, Zhiguang, Rani, Asha, Foster, Thomas C, Cruz-Almeida, Yenisel

“…Our study aimed to identify differentially methylated CpGs/regions and their enriched genomic pathways associated with underlying chronic musculoskeletal pain…”
Get full text

Human Brain and Blood N-Glycome Profiling in Alzheimer's Disease and Alzheimer's Disease-Related Dementias by Yu, Lei, Huo, Zhiguang, Yang, Jingyun, Palma-Gudiel, Helena, Boyle, Patricia A, Schneider, Julie A, Bennett, David A, Zhao, Jinying

“…Glycosylation, the process of adding glycans (i.e., sugars) to proteins, is the most abundant post-translational modification. N-glycosylation is the most…”
Get full text

Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry by Paden, William, Barko, Kelly, Puralewski, Rachel, Cahill, Kelly M., Huo, Zhiguang, Shelton, Micah A., Tseng, George C., Logan, Ryan W., Seney, Marianne L.

“…Women are approximately two times as likely to be diagnosed with major depressive disorder (MDD) compared to men. While sex differences in MDD might be driven…”
Get full text

Psychological profiles in adults with knee OA-related pain: a replication study by Johnson, Alisa J., Laffitte Nodarse, Chavier, Peraza, Julio A., Valdes-Hernandez, Pedro A., Montesino-Goicolea, Soamy, Huo, Zhiguang, Fillingim, Roger B., Cruz-Almeida, Yenisel

“…Introduction: Psychological factors have been associated with knee osteoarthritis pain severity and treatment outcomes, yet their combined contribution to…”
Get full text