Search Results - "Huo, Jiandong"

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Le Bas, Audrey, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…The SARS-CoV-2 virus is more transmissible than previous coronaviruses and causes a more serious illness than influenza. The SARS-CoV-2 receptor binding domain…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Potent cross-reactive antibodies following Omicron breakthrough in vaccinees by Nutalai, Rungtiwa, Zhou, Daming, Tuekprakhon, Aekkachai, Ginn, Helen M., Supasa, Piyada, Liu, Chang, Huo, Jiandong, Mentzer, Alexander J., Duyvesteyn, Helen M.E., Dijokaite-Guraliuc, Aiste, Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Constantinides, Bede, Webster, Hermione, Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Crook, Derrick, Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Paterson, Neil G., Williams, Mark A., Hall, David R., Mongkolsapaya, Juthathip, Fry, Elizabeth E., Dejnirattisai, Wanwisa, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD…”
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A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19 by Huo, Jiandong, Mikolajek, Halina, Le Bas, Audrey, Clark, Jordan J., Sharma, Parul, Kipar, Anja, Dormon, Joshua, Norman, Chelsea, Weckener, Miriam, Clare, Daniel K., Harrison, Peter J., Tree, Julia A., Buttigieg, Karen R., Salguero, Francisco J., Watson, Robert, Knott, Daniel, Carnell, Oliver, Ngabo, Didier, Elmore, Michael J., Fotheringham, Susan, Harding, Adam, Moynié, Lucile, Ward, Philip N., Dumoux, Maud, Prince, Tessa, Hall, Yper, Hiscox, Julian A., Owen, Andrew, James, William, Carroll, Miles W., Stewart, James P., Naismith, James H., Owens, Raymond J.

“…SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for…”
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Structure and Interactions of the Human Programmed Cell Death 1 Receptor by Cheng, Xiaoxiao, Veverka, Vaclav, Radhakrishnan, Anand, Waters, Lorna C., Muskett, Frederick W., Morgan, Sara H., Huo, Jiandong, Yu, Chao, Evans, Edward J., Leslie, Alasdair J., Griffiths, Meryn, Stubberfield, Colin, Griffin, Robert, Henry, Alistair J., Jansson, Andreas, Ladbury, John E., Ikemizu, Shinji, Carr, Mark D., Davis, Simon J.

“…PD-1, a receptor expressed by T cells, B cells, and monocytes, is a potent regulator of immune responses and a promising therapeutic target. The structure and…”
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Generation of SARS-CoV-2 escape mutations by monoclonal antibody therapy by Ragonnet-Cronin, Manon, Nutalai, Rungtiwa, Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Das, Raksha, Tuekprakhon, Aekkachai, Supasa, Piyada, Liu, Chang, Selvaraj, Muneeswaran, Groves, Natalie, Hartman, Hassan, Ellaby, Nicholas, Mark Sutton, J., Bahar, Mohammad W., Zhou, Daming, Fry, Elizabeth, Ren, Jingshan, Brown, Colin, Klenerman, Paul, Dunachie, Susanna J., Mongkolsapaya, Juthathip, Hopkins, Susan, Chand, Meera, Stuart, David I., Screaton, Gavin R., Rokadiya, Sakib

“…COVID-19 patients at risk of severe disease may be treated with neutralising monoclonal antibodies (mAbs). To minimise virus escape from neutralisation these…”
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A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75 by Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Liu, Chang, Zhou, Daming, Ginn, Helen M., Das, Raksha, Supasa, Piyada, Selvaraj, Muneeswaran, Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Duyvesteyn, Helen M.E., Mentzer, Alexander J., Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Paterson, Neil G., Williams, Mark A., Hall, David R., Plowright, Megan, Newman, Thomas A.H., Hornsby, Hailey, de Silva, Thushan I., Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have caused successive global waves of infection. These variants, with multiple…”
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Antigenic characterization of SARS-CoV-2 Omicron subvariants XBB.1.5, BQ.1, BQ.1.1, BF.7 and BA.2.75.2 by Zhu, Airu, Wei, Peilan, Man, Miao, Liu, Xuesong, Ji, Tianxing, Chen, Jiantao, Chen, Canjie, Huo, Jiandong, Wang, Yanqun, Zhao, Jincun

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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19 by Graham, Simon P., McLean, Rebecca K., Spencer, Alexandra J., Belij-Rammerstorfer, Sandra, Wright, Daniel, Ulaszewska, Marta, Edwards, Jane C., Hayes, Jack W. P., Martini, Veronica, Thakur, Nazia, Conceicao, Carina, Dietrich, Isabelle, Shelton, Holly, Waters, Ryan, Ludi, Anna, Wilsden, Ginette, Browning, Clare, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Hollinghurst, Philippa, Gilbride, Ciaran, Pulido, David, Moffat, Katy, Sharpe, Hannah, Allen, Elizabeth, Mioulet, Valerie, Chiu, Chris, Newman, Joseph, Asfor, Amin S., Burman, Alison, Crossley, Sylvia, Huo, Jiandong, Owens, Raymond J., Carroll, Miles, Hammond, John A., Tchilian, Elma, Bailey, Dalan, Charleston, Bryan, Gilbert, Sarah C., Tuthill, Tobias J., Lambe, Teresa

“…Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

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Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals by Parker, Joanne L, Deme, Justin C, Wu, Zhiyi, Kuteyi, Gabriel, Huo, Jiandong, Owens, Raymond J, Biggin, Philip C, Lea, Susan M, Newstead, Simon

“…The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in human physiology as the principal route for acquiring and retaining…”
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The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 protein by Girt, Georgina C., Lakshminarayanan, Abirami, Huo, Jiandong, Dormon, Joshua, Norman, Chelsea, Afrough, Babak, Harding, Adam, James, William, Owens, Raymond J., Naismith, James H.

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in the fluid has important uses in biotechnology, and is integral to many…”
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Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2 by Huo, Jiandong, Bas, Audrey Le, Ruza, Reinis R., Duyvesteyn, Helen M. E., Mikolajek, Halina, Malinauskas, Tomas, Tan, Tiong Kit, Rijal, Pramila, Dumoux, Maud, Ward, Philip N., Ren, Jingshan, Zhou, Daming, Harrison, Peter J., Weckener, Miriam, Clare, Daniel K., Vogirala, Vinod K., Radecke, Julika, Moynié, Lucile, Zhao, Yuguang, Gilbert-Jaramillo, Javier, Knight, Michael L., Tree, Julia A., Buttigieg, Karen R., Coombes, Naomi, Elmore, Michael J., Carroll, Miles W., Carrique, Loic, Shah, Pranav N. M., James, William, Townsend, Alain R., Stuart, David I., Owens, Raymond J., Naismith, James H.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41594-021-00566-w…”
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Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2 by Cornish, Katy, Huo, Jiandong, Jones, Luke, Sharma, Parul, Thrush, Joseph W, Abdelkarim, Sahar, Kipar, Anja, Ramadurai, Siva, Weckener, Miriam, Mikolajek, Halina, Liu, Sai, Buckle, Imogen, Bentley, Eleanor, Kirby, Adam, Han, Ximeng, Laidlaw, Stephen M, Hill, Michelle, Eyssen, Lauren, Norman, Chelsea, Le Bas, Audrey, Clarke, John, James, William, Stewart, James P, Carroll, Miles, Naismith, James H, Owens, Raymond J

“…The Omicron strains of SARS-CoV-2 pose a significant challenge to the development of effective antibody-based treatments as immune evasion has compromised most…”
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Mosaic RBD Nanoparticles Elicit Protective Immunity Against Multiple Human Coronaviruses in Animal Models by Zhang, Yanjun, Sun, Jing, Zheng, Jian, Li, Suxiang, Rao, Haiyue, Dai, Jun, Zhang, Zhaoyong, Wang, Yanqun, Liu, Donglan, Chen, Zhao, Ran, Wei, Zhu, Airu, Li, Fang, Yan, Qihong, Wang, Yiliang, Yu, Kuai, Zhang, Shengnan, Wang, Dong, Tang, Yanhong, Liu, Banghui, Cheng, Linling, Huo, Jiandong, Perlman, Stanley, Zhao, Jingxian, Zhao, Jincun

“…To combat SARS‐CoV‐2 variants and MERS‐CoV, as well as the potential re‐emergence of SARS‐CoV and spillovers of sarbecoviruses, which pose a significant threat…”
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Humoral responses against SARS-CoV-2 Omicron BA.2.11, BA.2.12.1 and BA.2.13 from vaccine and BA.1 serum by Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Nutalai, Rungtiwa, Das, Raksha, Zhou, Daming, Mentzer, Alexander J., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

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An investigation of hierachical protein recruitment to the inhibitory platelet receptor, G6B-b by Coxon, Carmen H, Sadler, Amanda J, Huo, Jiandong, Campbell, R Duncan

“…Platelet activation is regulated by both positive and negative signals. G6B-b is an inhibitory platelet receptor with an immunoreceptor tyrosine-based…”
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Production and Crystallization of Nanobodies in Complex with the Receptor Binding Domain of the SARS-CoV-2 Spike Protein by Bas, Audrey Le, Mikolajek, Halina, Huo, Jiandong, Dormon, Joshua, Naismith, James H, Owens, Raymond J

“…The receptor binding domain (RBD) of the spike protein of SARS-CoV-2 binds angiotensin converting enzyme-2 (ACE-2) on the surface of epithelial cells, leading…”
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Antigenic characterization of SARS-CoV-2 Omicron subvariant BA.4.6 by Dijokaite-Guraliuc, Aiste, Das, Raksha, Nutalai, Rungtiwa, Zhou, Daming, Mentzer, Alexander J., Liu, Chang, Supasa, Piyada, Dunachie, Susanna J., Lambe, Teresa, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Huo, Jiandong, Stuart, David I., Screaton, Gavin R.

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A novel online robust identification method for Xq of synchronous generator based on IGG criterion by Huang Zihua, Xue Ancheng, You Hongyu, Zhang Zhaoyang, Huo Jiandong

“…This paper proposes a robust on-line identification method for the synchronous generator's quadrature-axis synchronous reactance X q with steady-state PMU…”
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