Search Results - "Hunya, Akos"

Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc by Datki, Zsolt, Galik-Olah, Zita, Janosi-Mozes, Emese, Szegedi, Viktor, Kalman, Janos, Hunya, Ákos Gábor, Fulop, Livia, Tamano, Haruna, Takeda, Atsushi, Adlard, Paul A., Bush, Ashley I.

“…Aging and female sex are the major risk factors for Alzheimer’s disease and its associated brain amyloid-β (Aβ) neuropathology, but the mechanisms mediating…”
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Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts by Gombos, Imre, Crul, Tim, Piotto, Stefano, Güngör, Burcin, Török, Zsolt, Balogh, Gábor, Péter, Mária, Slotte, J Peter, Campana, Federica, Pilbat, Ana-Maria, Hunya, Akos, Tóth, Noémi, Literati-Nagy, Zsuzsanna, Vígh, Jr, László, Glatz, Attila, Brameshuber, Mario, Schütz, Gerhard J, Hevener, Andrea, Febbraio, Mark A, Horváth, Ibolya, Vígh, László

“…Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches, causing dysregulated heat shock…”
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The impact of dihydropyridine derivatives on the cerebral blood flow response to somatosensory stimulation and spreading depolarization by Szabó, Írisz, M. Tóth, Orsolya, Török, Zsolt, Varga, Dániel Péter, Menyhárt, Ákos, Frank, Rita, Hantosi, Dóra, Hunya, Ákos, Bari, Ferenc, Horváth, Ibolya, Vigh, László, Farkas, Eszter

“…Background and Purpose A new class of dihydropyridine derivatives, which act as co‐inducers of heat shock protein but are devoid of calcium channel antagonist…”
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Mild Hyperthermia-Induced Thermogenesis in the Endoplasmic Reticulum Defines Stress Response Mechanisms by Dukic, Barbara, Ruppert, Zsófia, Tóth, Melinda E, Hunya, Ákos, Czibula, Ágnes, Bíró, Péter, Tiszlavicz, Ádám, Péter, Mária, Balogh, Gábor, Erdélyi, Miklós, Timinszky, Gyula, Vígh, László, Gombos, Imre, Török, Zsolt

“…Previous studies reported that a mild, non-protein-denaturing, fever-like temperature increase induced the unfolded protein response (UPR) in mammalian cells…”
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Dihydropyridine Derivatives Modulate Heat Shock Responses and have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease by Kasza, Ágnes, Hunya, Ákos, Frank, Zsuzsa, Fülöp, Ferenc, Török, Zsolt, Balogh, Gábor, Sántha, Miklós, Bálind, Árpád, Bernáth, Sándor, Blundell, Katie L I M, Prodromou, Chrisostomos, Horváth, Ibolya, Zeiler, Hans-Joachim, Hooper, Philip L, Vigh, László, Penke, Botond

“…Heat shock proteins (Hsps) have chaperone activity and play a pivotal role in the homeostasis of proteins by preventing misfolding, by clearing aggregated and…”
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Involvement of small heat shock proteins, trehalose, and lipids in the thermal stress management in Schizosaccharomyces pombe by Glatz, Attila, Pilbat, Ana-Maria, Németh, Gergely L., Vince-Kontár, Katalin, Jósvay, Katalin, Hunya, Ákos, Udvardy, Andor, Gombos, Imre, Péter, Mária, Balogh, Gábor, Horváth, Ibolya, Vígh, László, Török, Zsolt

“…Changes in the levels of three structurally and functionally different important thermoprotectant molecules, namely small heat shock proteins (sHsps),…”
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Distinct Cellular Tools of Mild Hyperthermia-Induced Acquired Stress Tolerance in Chinese Hamster Ovary Cells by Tiszlavicz, Ádám, Gombos, Imre, Péter, Mária, Hegedűs, Zoltán, Hunya, Ákos, Dukic, Barbara, Nagy, István, Peksel, Begüm, Balogh, Gábor, Horváth, Ibolya, Vígh, László, Török, Zsolt

“…Mild stress could help cells to survive more severe environmental or pathophysiological conditions. In the current study, we investigated the cellular…”
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A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays by Mozes, Emese, Hunya, Akos, Posa, Aniko, Penke, Botond, Datki, Zsolt

“…Highlights ► Using brain tissue slices for measuring Aβ toxicity with MTT and LDH assay. ► Separate and simultaneous effect of OGD and Aβ on hippocampal slice…”
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A novel application of the fluorescent dye bis-ANS for labeling neurons in acute brain slices by Mozes, Emese, Hunya, Akos, Toth, Aniko, Ayaydin, Ferhan, Penke, Botond, Datki, Zsolt L

“…Highlights ► Cell-impermeant oligomer specific fluorescent dye, bis-ANS. ► Labeling mechanically damaged but still viable neurons in acute brain slices. ► Both…”
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A novel and simple fluorescence method for the measurement of presynaptic vesicular zinc release in acute hippocampal slices with a fluorescence plate reader by Datki, Zsolt L, Hunya, Ákos, Penke, Botond

“…Abstract The synaptic vesicles in the hippocampal neuronal terminals are abundantly supplied with zinc ions (Zn2+ ), which can be released into the synaptic…”
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Studies for Improving a Rat Model of Alzheimer's Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory by Kasza, Ágnes, Penke, Botond, Frank, Zsuzsanna, Bozsó, Zsolt, Szegedi, Viktor, Hunya, Ákos, Németh, Klaudia, Kozma, Gábor, Fülöp, Lívia

“…During the past 15 years, several genetically altered mouse models of human Alzheimer's disease (AD) have been developed. These costly models have greatly…”
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Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Aβ(1-42) and NAC treatment by Hunya, Ákos, Földi, István, Szegedi, Viktor, Soós, Katalin, Zarándi, Márta, Szabó, Antal, Zádori, Dénes, Penke, Botond, Datki, Zsolt L

“…Abstract Alpha-synuclein (αSN) plays a major role in numerous neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Intracellular…”
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Hydroximic acid derivatives: pleiotropic HSP co-inducers restoring homeostasis and robustness by Crul, Tim, Toth, Noemi, Piotto, Stefano, Literati-Nagy, Peter, Tory, Kalman, Haldimann, Pierre, Kalmar, Bernadett, Greensmith, Linda, Torok, Zsolt, Balogh, Gabor, Gombos, Imre, Campana, Federica, Concilio, Simona, Gallyas, Ferenc, Nagy, Gabor, Berente, Zoltan, Gungor, Burcin, Peter, Maria, Glatz, Attila, Hunya, Akos, Literati-Nagy, Zsuzsanna, Vigh, Jr, Laszlo, Hoogstra-Berends, Femke, Heeres, André, Kuipers, Irma, Loen, Lizette, Seerden, Jean-Paul, Zhang, Deli, Meijering, Roelien A M, Henning, Robert H, Brundel, Bianca J J M, Kampinga, Harm H, Koranyi, Laszlo, Szilvassy, Zoltan, Mandl, Jozsef, Sumegi, Balazs, Febbraio, Mark A, Horvath, Ibolya, Hooper, Philip L, Vigh, Laszlo

“…According to the "membrane sensor" hypothesis, the membrane's physical properties and microdomain organization play an initiating role in the heat shock…”
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Alzheimer risk factors age and female sex induce cortical A[beta] aggregation by raising extracellular zinc by Datki, Zsolt, Galik-Olah, Zita, Janosi-Mozes, Emese, Szegedi, Viktor, Kalman, Janos, Hunya, Ákos Gábor, Fulop, Livia

“…Aging and female sex are the major risk factors for Alzheimer's disease and its associated brain amyloid-[beta] (A[beta]) neuropathology, but the mechanisms…”
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Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment by Hunya, Akos, Földi, István, Szegedi, Viktor, Soós, Katalin, Zarándi, Márta, Szabó, Antal, Zádori, Dénes, Penke, Botond, Datki, Zsolt L

“…Alpha-synuclein (alphaSN) plays a major role in numerous neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Intracellular…”
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Fibrillar Abeta (1-42) enhances NMDA receptor sensitivity via the integrin signaling pathway by Uhász, Gábor J, Barkóczi, Balázs, Vass, Gabriella, Datki, Zsolt, Hunya, Akos, Fülöp, Lívia, Budai, Dénes, Penke, Botond, Szegedi, Viktor

“…The aggregated form of amyloid-beta (Abeta) (1-42) has been shown to increase N-methyl-D-aspartic acid (NMDA) evoked neuronal activity in vivo. Here we further…”
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Membranes in stress management: How membranes control the expression and cellular distribution of stress proteins by Vigh, László, Balogh, Gábor, Török, Zsolt, Gombos, Imre, Péter, Mária, Güngör, Burcin, Crul, Tim, Tóth, Noémi, Hunya, Ákos, Pilbat, Ana-Maria, Vigh, László, Glatz, Attila, Horváth, Ibolya

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Physiological Factors Could Enhance Amyloid-Beta Toxicity by Hunya, Ákos Gábor

“…In this section, I would like to summarize all the novel findings of my Ph.D work:• We developed the ExViS device for maintaining and treating tissue slices in…”
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