Search Results - "Huntly, B. J. P."

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia by Giotopoulos, G, Chan, W-I, Horton, S J, Ruau, D, Gallipoli, P, Fowler, A, Crawley, C, Papaemmanuil, E, Campbell, P J, Göttgens, B, Van Deursen, J M, Cole, P A, Huntly, B J P

“…Growing evidence links abnormal epigenetic control to the development of hematological malignancies. Accordingly, inhibition of epigenetic regulators is…”
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Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia by Dawson, M A, Gudgin, E J, Horton, S J, Giotopoulos, G, Meduri, E, Robson, S, Cannizzaro, E, Osaki, H, Wiese, M, Putwain, S, Fong, C Y, Grove, C, Craig, J, Dittmann, A, Lugo, D, Jeffrey, P, Drewes, G, Lee, K, Bullinger, L, Prinjha, R K, Kouzarides, T, Vassiliou, G S, Huntly, B J P

“…Recent evidence suggests that inhibition of bromodomain and extra-terminal (BET) epigenetic readers may have clinical utility against acute myeloid leukemia…”
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Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2 by Nangalia, J, Massie, C.E, Baxter, E.J, Nice, F.L, Gundem, G, Wedge, D.C, Avezov, E, Li, J, Kollmann, K, Kent, D.G, Aziz, A, Godfrey, A.L, Hinton, J, Martincorena, I, Van Loo, P, Jones, A.V, Guglielmelli, P, Tarpey, P, Harding, H.P, Fitzpatrick, J.D, Goudie, C.T, Ortmann, C.A, Loughran, S.J, Raine, K, Jones, D.R, Butler, A.P, Teague, J.W, O'Meara, S, McLaren, S, Bianchi, M, Silber, Y, Dimitropoulou, D, Bloxham, D, Mudie, L, Maddison, M, Robinson, B, Keohane, C, Maclean, C, Hill, K, Orchard, K, Tauro, S, Du, M.-Q, Greaves, M, Bowen, D, Huntly, B.J.P, Harrison, C.N, Cross, N.C.P, Ron, D, Vannucchi, A.M, Papaemmanuil, E, Campbell, P.J, Green, A.R

“…The authors show that the diverse mutations in CALR that occur in nonmutated JAK2 myeloproliferative diseases all introduce frameshift mutations that alter the…”
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Visual information processing during controlled hypoglycaemia in humans by McCrimmon, R. J., Deary, I. J., Huntly, B. J. P., MacLeod, K. J., Frier, B. M.

“…Summary A general impairment of congnitive performance occurs during acute insulin-induced hypoglycaemia, but little objective evidence is available for…”
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Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations, and role in leukemic transformation by Campbell, Peter J., Baxter, E. Joanna, Beer, Philip A., Scott, Linda M., Bench, Anthony J., Huntly, Brian J.P., Erber, Wendy N., Kusec, Rajko, Larsen, Thomas Stauffer, Giraudier, Stéphane, Le Bousse-Kerdilès, Marie-Caroline, Griesshammer, Martin, Reilly, John T., Cheung, Betty Y., Harrison, Claire N., Green, Anthony R.

“…The identification of an acquired mutation of JAK2 in patients with myeloproliferative disorders has raised questions about the relationship between…”
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Deletions of the derivative chromosome 9 occur at the time of the Philadelphia translocation and provide a powerful and independent prognostic indicator in chronic myeloid leukemia by Huntly, Brian J.P., Reid, Alistair G., Bench, Anthony J., Campbell, Lynda J., Telford, Nick, Shepherd, Patricia, Szer, Jeff, Prince, H. Miles, Turner, Paul, Grace, Colin, Nacheva, Elizabeth P., Green, Anthony R.

“…Chronic myeloid leukemia (CML) is characterized by formation of theBCR-ABL fusion gene, usually as a consequence of the Philadelphia (Ph) translocation between…”
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Molecular cytogenetics of polycythaemia vera: lack of occult rearrangements detectable by 20q LSP screening, CGH, and M-FISH by Gribble, S M, Reid, A G, Bench, A J, Huntly, B J P, Grace, C, Green, A R, Nacheva, E P

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The incidences of trisomy 8, trisomy 9 and D20S108 deletion in polycythaemia vera: an analysis of blood granulocytes using interphase fluorescence in situ hybridization by Westwood, N. B., Gruszka‐Westwood, A. M., Pearson, C. E., DeLord, C. F. M., Green, A. R., Huntly, B. J. P., Lakhani, A., McMullin, M. F., Pearson, T. C.

“…We have used interphase fluorescence in situ hybridization (IFISH) to detect trisomy 8, trisomy 9 and 20q deletion in circulating granulocytes from patients…”
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Recent advances in acute myeloid leukemia stem cell biology by HORTON, Sarah J, HUNTLY, Brian J. R

“…The existence of cancer stem cells has long been postulated, but was proven less than 20 years ago following the demonstration that only a small sub-fraction…”
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ESMO-Magnitude of Clinical Benefit Scale for haematological malignancies (ESMO-MCBS:H) version 1.0 by Kiesewetter, B., Dafni, U., de Vries, E.G.E., Barriuso, J., Curigliano, G., González-Calle, V., Galotti, M., Gyawali, B., Huntly, B.J.P., Jäger, U., Latino, N.J., Malcovati, L., Oosting, S.F., Ossenkoppele, G., Piccart, M., Raderer, M., Scarfò, L., Trapani, D., Zielinski, C.C., Wester, R., Zygoura, P., Macintyre, E., Cherny, N.I.

“…The European Society for Medical Oncology (ESMO)-Magnitude of Clinical Benefit Scale (MCBS) has been accepted as a robust tool to evaluate the magnitude of…”
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Imatinib improves but may not fully reverse the poor prognosis of patients with CML with derivative chromosome 9 deletions by Huntly, Brian J.P., Guilhot, Francois, Reid, Alistair G., Vassiliou, George, Hennig, Evelin, Franke, Christina, Byrne, Jennie, Brizard, Andre, Niederwieser, Dietger, Freeman-Edward, Julie, Cuthbert, Gavin, Bown, Nick, Clark, Richard E., Nacheva, Elizabeth P, Green, Anthony R, Deininger, Michael W.N.

“…Deletions of the derivative chromosome 9 occur in a subset of patients with Philadelphia chromosome–positive chronic myeloid leukemia (CML) and are associated…”
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Chromosome 20 deletions in myeloid malignancies : reduction of the common deleted region, generation of a PAC/BAC contig and identification of candidate genes by BENCH, A. J, NACHEVA, E. P, HUNT, A. R, HUNTLY, B. J. P, CAMPBELL, L. J, BENTLEY, D. R, DELOUKAS, P, GREEN, A. R, HOOD, T. L, HOLDEN, J. L, FRENCH, L, SWANTON, S, CHAMPION, K. M, LI, J, WHITTAKER, P, STAVRIDES, G

“…Deletion of the long arm of chromosome 20 represents the most common chromosomal abnormality associated with the myeloproliferative disorders (MPDs) and is…”
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L3MBTL, a candidate 20q tumour suppressor gene is not mutated in patients with myeloid malignancies and displays monoallelic methylation by Bench, A J, J Li, Huntly, B J P, Vassiliou, G S

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