Search Results - "Hunter, Richard"

Stress, Adaptation, and the Deep Genome: Why Transposons Matter by Hunter, Richard G

“…Synopsis Stress is a common, if often unpredictable life event. It can be defined from an evolutionary perspective as a force an organism perceives it must…”
Get full text

Mechanisms of stress in the brain by McEwen, Bruce S, Bowles, Nicole P, Gray, Jason D, Hill, Matthew N, Hunter, Richard G, Karatsoreos, Ilia N, Nasca, Carla

“…The brain perceives and adapts to stressors via multiple interacting molecular mechanisms involving the cell surface, cytoskeleton and epigenetic regulation…”
Get full text

Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder by Daskalakis, Nikolaos P., Provost, Allison C., Hunter, Richard G., Guffanti, Guia

“…Posttraumatic stress disorder (PTSD) is a pathologic response to trauma that impacts ∼8% of the population and is highly comorbid with other disorders, such as…”
Get full text

Editorial: Insights in emotion regulation and processing: 2022 by Hunter, Richard G.

Get full text

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress by McEwen, Bruce S., Eiland, Lisa, Hunter, Richard G., Miller, Melinda M.

“…The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and…”
Get full text

Epigenetic Mechanisms of the Glucocorticoid Receptor by Bartlett, Andrew A., Lapp, Hannah E., Hunter, Richard G.

“…The glucocorticoid receptor (GR) has been shown to be important for mediating cellular responses to stress and circulating glucocorticoids. Ligand-dependent…”
Get full text

Stress and corticosteroids regulate rat hippocampal mitochondrial DNA gene expression via the glucocorticoid receptor by Hunter, Richard G., Seligsohn, Ma’ayan, Rubin, Todd G., Griffiths, Brian B., Ozdemir, Yildirim, Pfaff, Donald W., Datson, Nicole A., McEwen, Bruce S.

“…Glucocorticoids (GCs) are involved in stress and circadian regulation, and produce many actions via the GC receptor (GR), which is classically understood to…”
Get full text

Epigenetic effects of stress and corticosteroids in the brain by Hunter, Richard G

“…Stress is a common life event with potentially long lasting effects on health and behavior. Stress, and the corticosteroid hormones that mediate many of its…”
Get full text

Stress and the dynamic genome: Steroids, epigenetics, and the transposome by Hunter, Richard G., Gagnidze, Khatuna, McEwen, Bruce S., Pfaff, Donald W.

“…Stress plays a substantial role in shaping behavior and brain function, often with lasting effects. How these lasting effects occur in the context of a fixed…”
Get full text

Waddington, Dynamic Systems, and Epigenetics by Tronick, Ed, Hunter, Richard G

“…Waddington coined the term "epigenetic" to attempt to explain the complex, dynamic interactions between the developmental environment and the genome that led…”
Get full text

Anxiety and Epigenetics by Bartlett, Andrew A, Singh, Rumani, Hunter, Richard G

“…Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression and substance abuse. Twin studies have shown that anxiety disorders…”
Get more information

Stress and glucocorticoid receptor regulation of mitochondrial gene expression by Lapp, Hannah E, Bartlett, Andrew A, Hunter, Richard G

“…Glucocorticoids have long been recognized for their role in regulating the availability of energetic resources, particularly during stress. Furthermore,…”
Get full text

Stress and anxiety across the lifespan: structural plasticity and epigenetic regulation by Hunter, Richard G, McEwen, Bruce S

“…The brain is the central organ of the body's response to and perception of stress. Both the juvenile and the adult brain show a significant capacity for…”
Get more information

Regulation of hippocampal H3 histone methylation by acute and chronic stress by Hunter, Richard G, McCarthy, Katharine J, Milne, Thomas A, Pfaff, Donald W, McEwen, Bruce S

“…The hippocampal formation is a brain region noted for its plasticity in response to stressful events and adrenal steroid hormones. Recent work has shown that…”
Get full text

Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response by Hunter, Richard G, Murakami, Gen, Dewell, Scott, Seligsohn, Ma’ayan, Baker, Miriam E. R, Datson, Nicole A, McEwen, Bruce S, Pfaff, Donald W

“…The hippocampus is a highly plastic brain region particularly susceptible to the effects of environmental stress; it also shows dynamic changes in epigenetic…”
Get full text

Toxic stress history and hypothalamic-pituitary-adrenal axis function in a social stress task: Genetic and epigenetic factors by Lapp, Hannah E., Ahmed, Sarah, Moore, Celia L., Hunter, Richard G.

“…Histories of early life stress (ELS) or social discrimination can reach levels of severity characterized as toxic to mental and physical health. Such toxic…”
Get full text

Regulatory Effects of Maternal Immune Activation and Environmental Enrichment on Glucocorticoid Receptor and FKBP5 Expression in Stress-sensitive Regions of the Offspring Brain by Maganga-Bakita, Ismael, Aiken, Ariel A., Puracchio, Madeline J., Kentner, Amanda C., Hunter, Richard G.

“…•MIA dysregulates the HPA function by altering the expression of FKBP5 and GR.•Maternal immune activation upregulates FKBP5 mRNA levels in the offspring’s…”
Get full text

Transposons, stress and the functions of the deep genome by Bartlett, Andrew A., Hunter, Richard G.

“…•Retrotransposons (RT) comprise the single largest fraction of mammalian genomes.•They are regulated by stress via epigenetic mechanisms.•Dysregulation of RT…”
Get full text

Early life exposures, neurodevelopmental disorders, and transposable elements by Lapp, Hannah E., Hunter, Richard G.

“…Transposable elements make up a much larger portion of the genome than protein-coding genes, yet we know relatively little about their function in the human…”
Get full text

In search of optimal resilience ratios: Differential influences of neurobehavioral factors contributing to stress-resilience spectra by Lambert, Kelly, Hunter, Richard G., Bartlett, Andrew A., Lapp, Hannah E., Kent, Molly

“…•The stress response is multifactorial and should be considered in specific contexts.•The regulation of multiple biobehavioral systems is necessary to avoid…”
Get full text