Search Results - "Hunter, John J"

Signaling Pathways for Cardiac Hypertrophy and Failure by Hunter, John J, Chien, Kenneth R

“…Heart failure is a leading cause of mortality in the United States. As a result of advances in genetic technology, a molecular basis of heart failure is…”
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MLP-Deficient Mice Exhibit a Disruption of Cardiac Cytoarchitectural Organization, Dilated Cardiomyopathy, and Heart Failure by Arber, Silvia, Hunter, John J, Ross, John, Hongo, Minoru, Sansig, Gilles, Borg, Jacques, Perriard, Jean-Claude, Chien, Kenneth R, Caroni, Pico

“…MLP is a LIM-only protein of terminally differentiated striated muscle cells, where it accumulates at actin-based structures involved in cytoarchitecture…”
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Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice by Bhaskar, Vinay, Yin, Johnny, Mirza, Amer M, Phan, Dan, Vanegas, Sandra, Issafras, Hassan, Michelson, Kristen, Hunter, John J, Kantak, Seema S

“…Abstract Objective Atherosclerosis is a condition that is increasingly contributing to worldwide mortality through complications such as stroke and myocardial…”
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Transthoracic echocardiography in models of cardiac disease in the mouse by TANAKA, N, DALTON, N, MAO, L, ROCKMAN, H. A, PETERSON, K. L, GOTTSHALL, K. R, HUNTER, J. J, CHIEN, K. R, ROSS, J. JR

“…Transthoracic echocardiography (M-mode and Doppler) offers a noninvasive approach for in vivo evaluation of the mouse heart. The present study examines its…”
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Human melastatin 1 (TRPM1) is regulated by MITF and produces multiple polypeptide isoforms in melanocytes and melanoma by Zhiqi, Song, Soltani, Mohammad H, Bhat, Kumar Megur R, Sangha, Namrata, Fang, Dong, Hunter, John J, Setaluri, Vijayasaradhi

“…Melastatin 1 (MLSN1), originally identified as melanoma metastasis suppressor, represents a TRPM subfamily of transient receptor potential (TRP) proteins which…”
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Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by aurora A : A novel pharmacodynamic method for measuring aurora a activity by LEROY, Patrick J, HUNTER, John J, HOAR, Kara M, BURKE, Krissy E, SHINDE, Vaishali, RUAN, Jason, BOWMAN, Douglas, GALVIN, Katherine, ECSEDY, Jeffrey A

“…Aurora A is a serine/threonine protein kinase essential for normal mitotic progression. Aberrant increased expression of Aurora A, which occurs frequently in…”
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Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1β Activity by Roell, Marina K., Issafras, Hassan, Bauer, Robert J., Michelson, Kristen S., Mendoza, Nerissa, Vanegas, Sandra I., Gross, Lisa M., Larsen, Paul D., Bedinger, Daniel H., Bohmann, David J., Nonet, Genevieve H., Liu, Naichi, Lee, Steve R., Handa, Masahisa, Kantak, Seema S., Horwitz, Arnold H., Hunter, John J., Owyang, Alexander M., Mirza, Amer M., Corbin, John A., White, Mark L.

“…Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of…”
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Ras-Dependent Pathways Induce Obstructive Hypertrophy in Echo-Selected Transgenic Mice by Gottshall, Kim R., Hunter, John J., Tanaka, Nobuaki, Dalton, Nancy, Becker, K. David, Ross, John, Chien, Kenneth R.

“…To overcome the genetic and interindividual variability frequently noted in complex phenotypes, we used echocardiographic selection to develop a substrain of…”
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Expression of a β -adrenergic Receptor Kinase 1 Inhibitor Prevents the Development of Myocardial Failure in Gene-Targeted Mice by Rockman, Howard A., Chien, Kenneth R., Choi, Dong-Ju, Iaccarino, Guido, Hunter, John J., Ross, John, Lefkowitz, Robert J., Koch, Walter J.

“…Heart failure is accompanied by severely impaired β -adrenergic receptor (β AR) function, which includes loss of β AR density and functional uncoupling of…”
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Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice by John J. Hunter, Nobuaki Tanaka, Howard A. Rockman, John Ross, Jr, Kenneth R. Chien

“…p21 has been implicated in the hypertrophic response of cultured cardiac myocytes to defined growth stimuli. To determine if activation of ras -dependent…”
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A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis (∗) by Hunter, John J., Parslow, Tristram G.

“…Bcl-2 and Bax are members of a family of cytoplasmic proteins that regulate apoptosis. The two proteins have highly similar amino acid sequences but are…”
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Chromosomal Localization and Genomic Characterization of the Mouse Melastatin Gene (Mlsn1) by Hunter, John J., Shao, Jing, Smutko, John S., Dussault, Barry J., Nagle, Deborah L., Woolf, Elizabeth A., Holmgren, Lisa M., Moore, Karen J., Shyjan, Andrew W.

“…We recently described a novel gene, melastatin, whose expression is inversely correlated with melanoma aggressiveness. Chromosomal localization of this gene…”
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Effects of deletion of muscle LIM protein on myocyte function by Su, Z, Yao, A, Zubair, I, Sugishita, K, Ritter, M, Li, F, Hunter, J J, Chien, K R, Barry, W H

“…Muscle LIM protein (MLP) may serve as a scaffold protein on the actin-based cytoskeleton, and mice deficient in this protein (MLPKO) have been recently…”
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Distinct Molecular Phenotypes in Murine Cardiac Muscle Development, Growth, and Hypertrophy by Schoenfeld, Jill R., Vasser, Mark, Jhurani, Parkash, Ng, Peter, Hunter, John J., Ross, Jr, John, Chien, Kenneth R., Lowe, David G.

“…The onset of cardiac hypertrophy is associated with characteristic changes in myocardial gene expression that are thought to recapitulate a developmental gene…”
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Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras by Karlon, W J, McCulloch, A D, Covell, J W, Hunter, J J, Omens, J H

“…A hallmark of certain cardiac diseases such as familial hypertrophic cardiomyopathy is focal myofiber disarray. Regional ventricular dysfunction occurs in…”
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Loss of Adrenergic Control of the Force-Frequency Relation in Heart Failure Secondary to Idiopathic or Ischemic Cardiomyopathy by Bhargava, Valmik, Shabetai, Ralph, Mathiäsen, Ronald A, Dalton, Nancy, Hunter, John J, Ross, John

“…This study was designed to determine whether the force-frequency effect on myocardial contractility, known to be importantly regulated by the adrenergic…”
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Loss of Adrenergic Control of the Force-Frequency Relation in Heart Failure Secondary to Idiopathic or Ischemic Cardiomyopathy 11This study was supported by SCOR grant HL-53733 in Heart Failure, an endowed chair of the American Heart Association, California Affiliate, San Diego County Division, San Diego, California; and the Richard D. Winter Fund, La Jolla, California by Bhargava, Valmik, Shabetai, Ralph, Mathiäsen, Ronald A, Dalton, Nancy, Hunter, John J, Ross, John

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Role of abortive retroviral infection of neurons in spongiform CNS degeneration by Sharpe, Arlene H, Hunter, John J, Chassler, Phillip, Jaenisch, Rudolf

“…Retroviruses are involved in several human neurological diseases with varying pathological features. Whether these diseases are due to a direct effect of the…”
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Targeting Gene Expression to Specific Cardiovascular Cell Types in Transgenic Mice by Hunter, John J, Zhu, Hong, Lee, Kevin J, Kubalak, Steven, Chien, Kenneth R

“…Transgenic techniques, which allow the introduction of exogenous genes into the genome of experimental animals, promise to bridge the gap between the in vitro…”
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The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy by Ramirez, M. Teresa, Sah, Valerie P., Zhao, Xiao-Lan, Hunter, John J., Chien, Kenneth R., Brown, Joan Heller

“…In neonatal rat ventricular myocytes, stimulation of the α1-adrenergic receptor (α1-AdrR) activates a program of genetic and morphological changes…”
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