Search Results - "Hunt, Nicholas H"

Tryptophan-catabolizing enzymes - party of three by Ball, Helen J, Jusof, Felicita F, Bakmiwewa, Supun M, Hunt, Nicholas H, Yuasa, Hajime J

“…Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that have independently evolved to catalyze the first…”
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Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice by Lam, Yan Y, Ha, Connie W Y, Campbell, Craig R, Mitchell, Andrew J, Dinudom, Anuwat, Oscarsson, Jan, Cook, David I, Hunt, Nicholas H, Caterson, Ian D, Holmes, Andrew J, Storlien, Len H

“…We investigated the relationship between gut health, visceral fat dysfunction and metabolic disorders in diet-induced obesity. C57BL/6J mice were fed control…”
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Blood‒Brain Barrier Pathology and CNS Outcomes in Streptococcus pneumoniae Meningitis by Yau, Belinda, Hunt, Nicholas H, Mitchell, Andrew J, Too, Lay Khoon

“…is a major meningitis-causing pathogen globally, bringing about significant morbidity and mortality, as well as long-term neurological sequelae in almost half…”
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Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function by Too, Lay Khoon, Li, Kong M., Suarna, Cacang, Maghzal, Ghassan J., Stocker, Roland, McGregor, Iain S., Hunt, Nicholas H.

“…•TDO-deficient mice increases exploratory activity during light and dark phases.•TDO-deficient mice display enhanced performance in patrolling and reversal…”
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Editorial: The Relationships Between Infectious Agents and Dementia by Too, Lay Khoon, Hunt, Nicholas H, Shinjyo, Noriko

“…Several molecular mechanisms potentially leading to neuronal cell death are explained, including direct neurotoxic effects of bacterial products and indirect…”
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Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis by Too, Lay Khoon, Yau, Belinda, Baxter, Alan G., McGregor, Iain S., Hunt, Nicholas H.

“…Toll-like receptor (TLR) 2 and 4 signalling pathways are central to the body’s defence against invading pathogens during pneumococcal meningitis. Whereas…”
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The Kynurenine Pathway of Tryptophan Degradation is Activated During Osteoblastogenesis by Vidal, Christopher, Li, Wei, Santner‐Nanan, Brigitte, Lim, Chai K., Guillemin, Gilles J., Ball, Helen J., Hunt, Nicholas H., Nanan, Ralph, Duque, Gustavo

“…The mechanisms involved in the anabolic effect of interferon gamma (IFNγ) on bone have not been carefully examined. Using microarray expression analysis, we…”
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Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria by El-Assaad, Fatima, Wheway, Julie, Hunt, Nicholas H, Grau, Georges E R, Combes, Valery

“…In patients with cerebral malaria (CM), higher levels of cell-specific microparticles (MP) correlate with the presence of neurological symptoms. MP are…”
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The role of granulocyte macrophage-colony-stimulating factor in acute intestinal inflammation by Xu, Yinghua, Hunt, Nicholas H, Bao, Shisan

“…An imbalance of mucosal proand anti-inflammatory cytokincs is crucial in the pathogenesis of inflammatory bowel disease （IBD）. GM-CSF influences the…”
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Current perspectives on the mechanism of action of artemisinins by Golenser, Jacob, Waknine, Judith H., Krugliak, Miriam, Hunt, Nicholas H., Grau, Georges E.

“…Artemisinin derivatives are the most recent single drugs approved and introduced for public antimalarial treatment. Although their recommended use is for…”
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Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice by Ball, Helen J., Sanchez-Perez, Angeles, Weiser, Silvia, Austin, Christopher J.D., Astelbauer, Florian, Miu, Jenny, McQuillan, James A., Stocker, Roland, Jermiin, Lars S., Hunt, Nicholas H.

“…Indoleamine 2,3-dioxygenase (INDO) and tryptophan 2,3-dioxygenase (TDO) each catalyze the first step in the kynurenine pathway of tryptophan metabolism. We…”
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Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis by Pai, Saparna, Qin, Jim, Cavanagh, Lois, Mitchell, Andrew, El-Assaad, Fatima, Jain, Rohit, Combes, Valery, Hunt, Nicholas H, Grau, Georges E R, Weninger, Wolfgang

“…During experimental cerebral malaria (ECM) mice develop a lethal neuropathological syndrome associated with microcirculatory dysfunction and intravascular…”
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Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis by Hackett, Mark J, McQuillan, James A, El-Assaad, Fatima, Aitken, Jade B, Levina, Aviva, Cohen, David D, Siegele, Rainer, Carter, Elizabeth A, Grau, Georges E, Hunt, Nicholas H, Lay, Peter A

“…Understanding biochemical mechanisms and changes associated with disease conditions and, therefore, development of improved clinical treatments, is relying…”
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Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria by Hunt, Nicholas H., Grau, Georges E.

“…Cerebral malaria (CM) is a major life-threatening complication of Plasmodium falciparum infection. The nature of the pathogenetic processes leading to the…”
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Applicability of Redirecting Artemisinins for New Targets by Golenser, Jacob, Hunt, Nicholas H., Birman, Ida, Jaffe, Charles L., Zech, Johanna, Mäder, Karsten, Gold, Daniel

“…Employing new therapeutic indications for drugs that are already approved for human use has obvious advantages, including reduced costs and timelines, because…”
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Technical Advance: Autofluorescence as a tool for myeloid cell analysis by Mitchell, Andrew J., Pradel, Lydie C., Chasson, Lionel, Van Rooijen, Nico, Grau, Georges E., Hunt, Nicholas H., Chimini, Giovanna

“…The autofluorescence of myeloid cell populations is heterogeneous and can be used as a tool for identification and phenotyping of myeloid subsets. Cellular AF…”
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An effective, low-cost method for achieving and maintaining hypoxia during cell culture studies by Bakmiwewa, Supun M, Heng, Benjamin, Guillemin, Gilles J, Ball, Helen J, Hunt, Nicholas H

“…Here we report a simple new method for exposing cells to normoxic and hypoxic conditions using vacuum bags, normally employed for food storage, to establish…”
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Role of the Gut in Visceral Fat Inflammation and Metabolic Disorders by Lam, Yan Y., Mitchell, Andrew J., Holmes, Andrew J., Denyer, Gareth S., Gummesson, Anders, Caterson, Ian D., Hunt, Nicholas H., Storlien, Len H.

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Total Synthesis and Antimalarial Activity of Symplostatin 4 by Conroy, Trent, Guo, Jin T, Hunt, Nicholas H, Payne, Richard J

“…The first total synthesis of symplostatin 4, a marine cyanobacterium-derived natural product, is described. Notable features of the route include the efficient…”
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Total Synthesis, Stereochemical Assignment, and Antimalarial Activity of Gallinamide A by Conroy, Trent, Guo, Jin T., Linington, Roger G., Hunt, Nicholas H., Payne, Richard J.

“…The total synthesis and stereochemical assignment of gallinamide A, an antimalarial depsipeptide of cyanobacterial origin, is described. Synthesis of the four…”
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