Search Results - "Hunt, Mary C."

The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolism by Hunt, Mary C., Siponen, Marina I., Alexson, Stefan E.H.

“…The importance of peroxisomes in lipid metabolism is now well established and peroxisomes contain approximately 60 enzymes involved in these lipid metabolic…”
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Regulation of peroxisomal lipid metabolism: The role of acyl-CoA and coenzyme A metabolizing enzymes by Hunt, Mary C., Tillander, Veronika, Alexson, Stefan E.H.

“…Peroxisomes are nearly ubiquitous organelles involved in a number of metabolic pathways that vary between organisms and tissues. A common metabolic function in…”
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Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target by Galdino, Anna Clara M, Viganor, Lívia, de Castro, Alexandre A, da Cunha, Elaine F F, Mello, Thaís P, Mattos, Larissa M, Pereira, Marcos D, Hunt, Mary C, O'Shaughnessy, Megan, Howe, Orla, Devereux, Michael, McCann, Malachy, Ramalho, Teodorico C, Branquinha, Marta H, Santos, André L S

“…Elastase B (lasB) is a multifunctional metalloenzyme secreted by the gram-negative pathogen , and this enzyme orchestrates several physiopathological events…”
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The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism by Hunt, Mary C, Alexson, Stefan E.H

“…Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential…”
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Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria by Tillander, Veronika, Arvidsson Nordström, Elisabet, Reilly, Jenny, Strozyk, Malgorzata, Van Veldhoven, Paul P, Hunt, Mary C, Alexson, Stefan E. H

“…Acyl-CoA thioesterase (ACOT) activities are found in prokaryotes and in several compartments of eukaryotes where they hydrolyze a wide range of acyl-CoA…”
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The acyl-CoA thioesterase I is regulated by PPARα and HNF4α via a distal response element in the promoter by Dongol, Bikesh, Shah, Yatrik, Kim, Insook, Gonzalez, Frank J., Hunt, Mary C.

“…The cytosolic acyl-coenzyme A thioesterase I (Acot1) is an enzyme that hydrolyzes long-chain acyl-CoAs of C12-C20-CoA in chain length to the free fatty acid…”
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Nudix Hydrolase 7 is an Acyl-CoA Diphosphatase Involved in Regulating Peroxisomal Coenzyme A Homeostasis by Reilly, Sarah-Jayne, Tillander, Veronika, Ofman, Rob, Alexson, Stefan E.H, Hunt, Mary C

“…Coenzyme A (CoASH) is an obligate cofactor for lipids undergoing β-oxidation in peroxisomes. Although the peroxisomal membrane appears to be impermeable to…”
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The Identification of a Succinyl-CoA Thioesterase Suggests a Novel Pathway for Succinate Production in Peroxisomes by Westin, Maria A.K., Hunt, Mary C., Alexson, Stefan E.H.

“…Dicarboxylic acids are formed by ω-oxidation of fatty acids in the endoplasmic reticulum and degraded as the CoA ester via β-oxidation in peroxisomes. Both…”
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Characterization of an Acyl-CoA Thioesterase That Functions as a Major Regulator of Peroxisomal Lipid Metabolism by Hunt, Mary C, Solaas, Karianne, Kase, B Frode, Alexson, Stefan E H

“…Peroxisomes function in β-oxidation of very long and long-chain fatty acids, dicarboxylic fatty acids, bile acid intermediates, prostaglandins, leukotrienes,…”
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revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases by Hunt, Mary C, Yamada, Junji, Maltais, Lois J, Wright, Mathew W, Podesta, Ernesto J, Alexson, Stefan E. H

“…Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated,…”
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The Human Bile Acid-CoA:Amino Acid N-Acyltransferase Functions in the Conjugation of Fatty Acids to Glycine by O'Byrne, James, Hunt, Mary C., Rai, Dilip K., Saeki, Masayumi, Alexson, Stefan E.H.

“…Bile acid-CoA:amino acid N-acyltransferase (BACAT) catalyzes the conjugation of bile acids to glycine and taurine for excretion into bile. By use of…”
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Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans by Waluk, Dominik P, Schultz, Niklas, Hunt, Mary C

“…The discovery of glycine conjugates of long-chain fatty acids (N-acyl glycines) in the brain and other non-neuronal tissues has led to the identification of an…”
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N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic β-cells by Waluk, Dominik P., Vielfort, Katarina, Derakhshan, Sepide, Aro, Helena, Hunt, Mary C.

“…► N-Acyl taurines function as novel insulin secretagogues. ► N-Arachidonoyl taurine signals through TRPV1 channels in pancreatic β-cells. ► Taurine-conjugated…”
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Differential regulation of cytosolic and peroxisomal bile acid amidation by PPARα activation favors the formation of unconjugated bile acids by Solaas, Karianne, Kase, B. Frode, Pham, Viet, Bamberg, Krister, Hunt, Mary C., Alexson, Stefan E.H.

“…In human liver, unconjugated bile acids can be formed by the action of bile acid-CoA thioesterases (BACTEs), whereas bile acid conjugation with taurine or…”
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N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells by Chatzakos, Vicky, Slätis, Katharina, Djureinovic, Tatjana, Helleday, Thomas, Hunt, Mary C.

“…Endocannabinoids have been implicated in cancer development and cause heterogenous effects in tumor cells, by inducing apoptosis, reducing migration, causing…”
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Reversible lysine acetylation regulates activity of human glycine N-acyltransferase-like 2 (hGLYATL2): implications for production of glycine-conjugated signaling molecules by Waluk, Dominik P, Sucharski, Filip, Sipos, Laszlo, Silberring, Jerzy, Hunt, Mary C

“…Lysine acetylation is a major post-translational modification of proteins and regulates many physiological processes such as metabolism, cell migration, aging,…”
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Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism by Hunt, Mary C., Alexson, Stefan E.H.

“…Peroxisomes are single membrane bound organelles present in almost all eukaryotic cells, and to date have been shown to contain approximately 60 identified…”
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Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs by Hunt, Mary C, Rautanen, Anna, Westin, Maria A.K, Svensson, L. Thomas, Alexson, Stefan E.H

“…The maintenance of cellular levels of free fatty acids and acyl-CoAs, the activated form of free fatty acids, is extremely important, as imbalances in lipid…”
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peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids by Reilly, Sarah-Jayne, O'Shea, Ethna M, Andersson, Ulla, O'Byrne, James, Alexson, Stefan E.H, Hunt, Mary C

“…A wide variety of endogenous carboxylic acids and xenobiotics are conjugated with amino acids, before excretion in urine or bile. The conjugation of carboxylic…”
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Peroxisomes Contain a Specific Phytanoyl-CoA/Pristanoyl-CoA Thioesterase Acting as a Novel Auxiliary Enzyme in α- and β-Oxidation of Methyl-branched Fatty Acids in Mouse by Westin, Maria A.K., Hunt, Mary C., Alexson, Stefan E.H.

“…Phytanic acid and pristanic acid are derived from phytol, which enter the body via the diet. Phytanic acid contains a methyl group in position three and,…”
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